生津汤对干燥综合征患者AQP5及炎症因子的影响-《西部中医药》

文章信息/Info

Title:: Influence of Body Fluid-generating Decoction on AQP5 and Inflammatory Factors in Patients with Primary Sj?gren′s Syndrome

Author(s):: ZHANG Yifan, SUN Minghui; Clinical Laboratory Center, The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China

Keywords:: primary Sj?gren's syndrome; AQP5; inflammatory factors; TCM symptom scores; the theory of sour-sweet transformed into; body fluid-generating decoction

摘要:: 目的观察生津汤对气阴两虚型原发性干燥综合征（primary Sj?gren′s Syndrome，pSS）患者血清水通道蛋白5（aquaporin 5，AQP5）、白细胞介素10（interleukin-10，IL-10）、IL-17等表达的影响。方法将60例气阴两虚型pSS女性患者随机分为中药组和西药组各30例，中药组予生津汤，西药组予硫酸羟氯喹片，连续治疗12周后比较两组患者治疗前后中医症状评分、Schirmer Ⅰ试验值及血清免疫球蛋白G（immunoglobulin G，IgG）、C反应蛋白（C-reaction protein，CRP）、AQP5、IL-17、IL-10表达水平。结果治疗后两组患者中医症状积分及血清IgG、CRP、IL-17表达降低，Schirmer Ⅰ试验值、IL-10、AQP5表达升高（P＜0.05），除CRP外，中药组其余各指标改善程度均优于西药组（P＜0.05）。结论基于酸甘化阴理论的生津汤能改善pSS患者临床症状，其作用机制可能与生津汤能调节AQP5及IL-17、IL-10等炎症因子表达，抑制机体炎症反应有关。

Abstract:: ObjectiveTo observe the influence of Shengjin Tang (body fluid-generating decoction) on the expressions of AQP5, IL-10 and IL-17 in patients suffering Qi and Yin deficiency pattern primary Sj?gren's syndrome (pSS). MethodsSixty patients were randomly allocated to TCM group and Western medicine group with 30 cases in each group, TCM group took body fluid-generating decoction, and hydroxychloroquine sulfate tablets were dispensed to Western medicine group, both groups were treated for 12 weeks consecutively, to compare TCM symptom scales, Schirmer Ⅰ test values, the expressions of IgG, CRP, AQP5, IL-17 and IL-10 in the two groups before and after the treatment. ResultsAfter the treatment, TCM symptom scores, and the expressions of IgG, CRP and IL-17 lowered in the two groups, Schirmer Ⅰ test values, the expressions of IL-10 and AQP5 increased (P<0.05), except for CRP, the improvements of other indexes of TCM group were better than these of Western medicine group (P<0.05). ConclusionBody fluid-generating decoction, on the foundation of the theory of sour-sweet transformed into Yin, could improve pSS patients' clinical symptoms, and its mechanism might be related to that the decoction could regulate the expressions of AQP5, IL-17 and IL-10, and inhibit inflammatory response in human body.