[1]党林林,张瑞芬,王智业,等.蒙药当贡-3胶囊治疗稳定型心绞痛临床观察[J].西部中医药,2025,38(01):48-53.[doi:10.12174/j.issn.2096-9600.2025.01.11]
　DANG Linlin,ZHANG Ruifen,WANG Zhiye,et al.Clinical Observation on Mongolian Medicine Danggong-3 Capsules in the Treatment of Stable Angina Pectoris[J].Western Journal of Traditional Chinese Medicine,2025,38(01):48-53.[doi:10.12174/j.issn.2096-9600.2025.01.11]
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蒙药当贡-3胶囊治疗稳定型心绞痛临床观察()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年01期
页码:
48-53
栏目:
民族医药
出版日期:
2025-01-15

文章信息/Info

Title:
Clinical Observation on Mongolian Medicine Danggong-3 Capsules in the Treatment of Stable Angina Pectoris
作者:
党林林1, 张瑞芬1, 王智业2, 黄新生1, 张海荣1, 贾婷婷1, 赵建1, 钟鑫1
1.内蒙古自治区中医医院，内蒙古 呼和浩特 010020
2.包头市中心医院，内蒙古 包头 014040
Author(s):
DANG Linlin1, ZHANG Ruifen1, WANG Zhiye2, HUANG Xinsheng1, ZHANG Hairong1, JIA Tingting1, ZHAO Jian1, ZHONG Xin1
1.Inner Mongolia Hospital of Traditional Chinese Medicine, Hohehot 010020, China
2.Baotou Central Hospital, Baotou 014040, China
关键词:
稳定型心绞痛; 蒙药当贡-3; 一氧化氮合酶; 白细胞介素6; 脂蛋白相关磷脂酶A2; 血脂
Keywords:
stable angina pectoris; Mongolian medicine -3 capsules; NOS; IL-6; LP-PLA2; blood lipid
分类号:
R29
DOI:
10.12174/j.issn.2096-9600.2025.01.11
文献标志码:
B
摘要:
目的观察蒙药当贡-3胶囊治疗稳定型心绞痛的临床疗效并分析其作用机理。 方法用计算机将100例心绞痛患者（稳定型）通过随机数字表法分为对照组和试验组，每组50例。在西医常规治疗的基础上，试验组口服蒙药当贡-3胶囊，对照组口服安慰剂，共治疗8周。比较两组患者临床总疗效、心绞痛疼痛程度积分、硝酸甘油使用量、一氧化氮合酶（nitric oxide synthase，NOS）、白细胞介素6（interleukin，IL-6）、脂蛋白相关磷脂酶A2（lipoprotein phospholipase A2，Lp-PLA2）、总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、低密度脂蛋白胆固醇（low Density lipoprotein cholesterol，LDL-C）、高密度脂蛋白胆固醇（high Density lipoprotein cholesterol，HDL-C）等指标，并观察不良反应。 结果试验组总有效率［87.5%（42/48）］高于对照组［70.8%（34/48）］（P＜0.05）；治疗后两组患者硝酸甘油使用量、心绞痛疼痛程度积分均下降（P＜0.05），且试验组下降程度大于对照组（P＜0.05）；试验组病情改善较对照组显著（P＜0.05）；治疗后两组患者NOS、HDL-C水平均升高（P＜0.05），Lp-PLA2、IL-6、TC、TG、LDL-C水平均下降，且试验组各检测指标升高或降低较对照组更显著（P＜0.05）。 结论蒙药当贡-3胶囊能够降低稳定型心绞痛患者疼痛程度，调节血脂水平，减少硝酸甘油使用量，提高临床疗效。
Abstract:
ObjectiveTo investigate curative effects of Mongolian medicine Danggong-3 capsules in the treatment of stable angina pectoris (SAP) and analyze the mechanism. MethodsA hundred of SAP patients were allocated to the control group and the experiment group using random number table method with 50 cases in each group. Based on routine therapy of Western medicine, the experiment group took Mongolian medicine the capsules orally, and the control group the placebo, altogether for eight weeks. To compare overall clinical efficacy, VAS scores of angina pectoris, the dosage of nitroglycerin, the levels of NOS, IL-6, Lp-PLA2, TC, TG, LDL-C and HDL-C in the two groups, and observe the adverse reactions. ResultsTotal effective rate of the experiment group was [87.5%(42/48)], higher than [70.8%(34/48)] of the control group (P<0.05); after the treatment, the dosage of nitroglycerin, and VAS scores of angina pectoris were lowered in the two groups (P<0.05), and the decrease of the experiment group was greater than that of the control group (P<0.05); the improvements of the patients’ conditions of the experiment group were more remarkable (P<0.05); after the treatment, the levels of NOS and HDL-C elevated in the two groups (P<0.05), the levels of Lp-PLA2, IL-6, TC, TG and LDL-C were reduced, the increase or decrease of different detection indexes was more apparent compared with the control group (P<0.05). ConclusionMongolian medicine Danggong-3 capsules could mitigate the pain in SAP patients, adjust the levels of blood lipid, reduce the dose of nitroglycerin and improve clinical effects.

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备注/Memo

备注/Memo:
党林林（1993—），女，硕士学位，主治医师。研究方向：心血管相关疾病的诊治。内蒙古自然科学基金（2019MS08074）；内蒙古自治区科技计划项目（JH20180086）；内蒙古医科大学科技处项目（YKD2018KJBW（LH）069）。
更新日期/Last Update: 2025-01-15