[1]胡芳晓,杨传华,杨洁.基于血脉理论辨治靶向药物所致心律失常[J].西部中医药,2026,39(03):50-53.[doi:10.12174/j.issn.2096-9600.2026.03.11]
　HU Fangxiao,YANG Chuanhua,YANG Jie.Targeted Drug-induced Arrhythmias Differentiation Based on Blood Vessel Theory[J].Western Journal of Traditional Chinese Medicine,2026,39(03):50-53.[doi:10.12174/j.issn.2096-9600.2026.03.11]
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基于血脉理论辨治靶向药物所致心律失常()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年03期
页码:
50-53
栏目:
学术探讨
出版日期:
2026-03-15

文章信息/Info

Title:
Targeted Drug-induced Arrhythmias Differentiation Based on Blood Vessel Theory
作者:
胡芳晓1, 杨传华2, 杨洁2
1.山东中医药大学中医学院，山东 济南 250011
2.山东中医药大学附属医院，山东 济南 250011
Author(s):
HU Fangxiao1, YANG Chuanhua2, YANG Jie2
1.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250011, China
2.Affiliated Hospital to Shandong University of Traditional Chinese Medicine, Jinan 250011, China
关键词:
心律失常; 靶向药物; 不良反应; 血脉理论
Keywords:
arrhythmias; targeted drug; adverse reaction; blood vessel theory
分类号:
R256.21
DOI:
10.12174/j.issn.2096-9600.2026.03.11
文献标志码:
A
摘要:
目的探讨运用中医“血脉理论”辨治靶向药物所致心律失常的理论依据与临床思路。 方法基于“血脉理论”，从“气-血-脉”一体观及“心主血脉”的核心思想出发，结合现代医学对靶向药物心脏毒性的认知，分析靶向药物所致心律失常的中医病机特点；结合临床案例，阐释以益气养血、通脉复脉为治法的方药应用思路及临床疗效。 结果靶向药物所致心律失常的核心病机为“药毒”耗伤气血，致心气亏虚、心血不足、血脉失养、心脉失和。基于“血脉理论”强调恢复“气-血-脉-心”系统的动态平衡，临床常用炙甘草汤等方剂益气养血、温通心脉，使气血充盈、脉道通利、心体得养，进而改善心悸症状、稳定心律。 结论“血脉理论”为辨治靶向药物所致心律失常提供了系统的理论框架与有效的治疗路径，体现了中医药在防治靶向治疗相关心脏毒性中的独特优势，有助于延长靶向药物的有效治疗周期，改善肿瘤患者的生存质量。
Abstract:
ObjectiveTo explore theoretical reference and clinical thinking for the differentiation of targeted drug-induced arrhythmias on the foundation of "blood vessel" theory. MethodsBased on "blood vessel theory", starting from the holistic view of "Qi, blood and vessels" as an integrated entity and the core principle of "heart governing the blood and vessels", and integrating the understanding of targeted drug-induced cardiotoxicity in modern medicine, the study explores the pathogenesis of targeted drug-induced arrhythmias, and discusses the application approach of the prescriptions and herbs for benefiting Qi and nourishing blood, unblocking and restoring the vessels and clinical effects in clinical cases. ResultsThe core pathogenesis of targeted drug-induced arrhythmias lies in "drug toxicity" consuming Qi and blood, inducing the insufficiency of cardiac Qi, depletion of heart blood, malnutrition of blood vessels, and blood vessel disharmony. The dynamic equilibrium of "Qi - blood - vessel - heart" is emphasized to restore based on "blood vessel theory", the prescription such as Zhigancao decoction is commonly used in clinic for benefiting Qi and nourishing blood, warming and unblocking heart and blood vessels, to replenish Qi and blood, to smooth heart and vessels, and to nourish heart, thereby improving the symptoms of palpitations, and stabilizing the heart rhythm. Conclusion"Blood vessel theory" could produce a systematic theoretical framework and effective therapeutic pathways for the differentiation and treatment of targeted drug-induced arrhythmias, embodying the unique advantages of TCM in the prevention and treatment of targeted drug-induced cardiotoxicity, and it contributes to extending the effective therapeutic cycle of targeted drug and enhancing the quality of life for oncology patients.

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备注/Memo

备注/Memo:
国家自然科学基金面上项目（8237152027）；国家自然科学基金青年科学基金项目（81804061）；泰山学者岗位建设资金资助项目（2018-35）；济南市科技计划项目（201805078）。胡芳晓（1996—），女，博士学位，医师。研究方向：中医心系疾病的临床研究。
更新日期/Last Update: 2026-03-15