[1]高占,吴会敏,孟美玲,等.中药治疗围绝经期综合征Meta分析[J].西部中医药,2026,39(03):65-70.[doi:10.12174/j.issn.2096-9600.2026.03.14]
　GAO Zhan,WU Huimin,MENG Meiling,et al.Traditional Chinese Medicine in the Treatment of Perimenopausal Syndrome: a Meta-analysis[J].Western Journal of Traditional Chinese Medicine,2026,39(03):65-70.[doi:10.12174/j.issn.2096-9600.2026.03.14]
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中药治疗围绝经期综合征Meta分析()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年03期
页码:
65-70
栏目:
二次研究
出版日期:
2026-03-15

文章信息/Info

Title:
Traditional Chinese Medicine in the Treatment of Perimenopausal Syndrome: a Meta-analysis
作者:
高占1, 吴会敏2, 孟美玲2, 李冬3, 高明周1
1.山东中医药大学，山东 济南 250355
2.上海市嘉定区精神卫生中心，上海 200000
3.上海市嘉定区中心医院，上海 200000
Author(s):
GAO Zhan1, WU Huimin2, MENG Meiling2, LI Dong3, GAO Mingzhou1
1.Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2.Shanghai City Jiading District Mental Health Center, Shanghai 200000, China
3.Shanghai City Jiading District Central Hospital, Shanghai 200000, China
关键词:
围绝经期综合征; 中药; 临床疗效; 系统评价; Meta分析
Keywords:
perimenopausal syndrome; traditional Chinese medicine; clinical effects; systematic review; Meta analysis
分类号:
R271.19
DOI:
10.12174/j.issn.2096-9600.2026.03.14
文献标志码:
A
摘要:
目的采用Meta分析方法评价中药治疗围绝经期综合征的临床疗效与安全性。 方法计算机检索中国知网、万方、维普、PubMed、The Cochrane Library数据库，检索时限为2011年1月1日至2021年1月26日。运用RevMan 5.4软件对研究中的数据进行Meta分析。根据Cochrane 5.1手册标准对纳入的研究进行质量评价与偏倚风险评估。 结果共纳入19篇随机对照试验，1744例患者。Meta分析结果显示：共纳入19篇随机对照试验（randomized controlled trials，RCTs），涉及1744例患者。Meta分析结果显示：与对照组相比，治疗组临床总有效率更高（RR=1.19，95%CI：1.10～1.29，P＜0.0001），差异有统计学意义；治疗组较对照组可显著降低Kupperman评分（MD=-2.28，95%CI：-2.80～-1.76，P＜0.000 01），差异有统计学意义；在提升雌二醇（estradiol，E2）水平方面，治疗组优于利维爱组（MD=1.24，95%CI：0.11～2.38，P=0.03）和雌激素组（MD=7.20，95%CI：4.31～10.09，P＜0.000 01），差异有统计学意义；但治疗组与雌孕激素序贯用药组在提升雌二醇水平方面比较（MD=-1.36，95%CI：-3.65～0.94，P=0.25），差异无统计学意义；两组在降低促卵泡生成素（follicle-stimulating hormone，FSH）水平方面比较（MD=-0.86，95%CI：-3.12～1.41，P=0.46），差异无统计学意义；治疗组较对照组能明显改善促黄体生成素（luteinizing hormone，LH）水平（MD=-1.59，95%CI：-2.35～-0.83，P＜0.0001），差异有统计学意义。 结论中药治疗围绝经期综合征的临床疗效优于常规西药治疗，且安全性良好。
Abstract:
ObjectiveTo assess clinical effects and the safety of Traditional Chinese medicine in the trea-tment of perimenopausal syndrome using Meta analysis. MethodsComputer-based retrieval was conducted in CNKI, Wanfang, VIP, PubMed and the Cochrane Library, and the retrieval time limit ranged from January 1st, 2011 to January 26th, 2021. RevMan 5.4 software was applied to conduct the Meta analysis of the data of the study. Quality evaluation and the risk of bias assessment for the included quality were conducted according to the standard of Cochrane 5.1 handbook. ResultsThe study has included 19 randomized controlled trials (RCTs) and 1744 patients. Meta analysis results revealed that, compared with the control group, clinical total effective rate of the treatment group was higher (RR=1.19, 95%CI:1.10 - 1.29, P<0.000 1), and the difference had statistical meaning; the treatment group could lower the Kupperman scores (MD=-2.28, 95%CI:-2.80 - -1.76, P<0.000 1) noticeably than the control group, and the difference had statistical meaning; the treatment group was better than Livial group (MD=1.24, 95%CI:0.11 - 2.38, P=0.03) and estrogen group (MD=7.20, 95%CI:4.31 - 10.09, P<0.000 1) in lifting the levels of estradiol, and the difference was statistically significant; while the difference had no statistical meaning in raising the levels of estradiol between the treatment group and Estrogen-progestogen sequential therapy group (MD=-1.36, 95%CI:-3.65 - 0.94, P=0.25); the difference showed no statistical meaning in lowering the levels of FSH (MD=-0.86, 95%CI:-3.12 - 1.41, P=0.46) between the two groups; compared with the control group, the treatment group could obviously improve the levels of LH (MD=-1.59, 95%CI:-2.35 - -0.83, P<0.000 1), and the difference was statistically significant. ConclusionTraditional Chinese medicine in the treatment of perimenopausal syndrome is better than routine Western medicine with good safety.

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备注/Memo

备注/Memo:
国家自然科学基金（82204958）。高占（1998—），男，在读博士研究生。研究方向：中医藏象学的微观机制。
更新日期/Last Update: 2026-03-15