[1]周密,王东军,孙璇,等.生化汤联合缩宫素治疗产后出血的系统评价和Meta分析[J].西部中医药,2026,39(03):97-102.[doi:10.12174/j.issn.2096-9600.2026.03.19]
　ZHOU Mi,WANG Dongjun,SUN Xuan,et al.Systematic Evaluation and Meta-analysis of Shenghua Decoction and Oxytocin in Treating Postpartum Hemorrhage[J].Western Journal of Traditional Chinese Medicine,2026,39(03):97-102.[doi:10.12174/j.issn.2096-9600.2026.03.19]
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生化汤联合缩宫素治疗产后出血的系统评价和Meta分析()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年03期
页码:
97-102
栏目:
二次研究
出版日期:
2026-03-15

文章信息/Info

Title:
Systematic Evaluation and Meta-analysis of Shenghua Decoction and Oxytocin in Treating Postpartum Hemorrhage
作者:
周密, 王东军, 孙璇, 田之魁, 关媛媛, 田春颖, 王泓午
天津中医药大学，天津 301617
Author(s):
ZHOU Mi, WANG Dongjun, SUN Xuan, TIAN Zhikui, GUAN Yuanyuan, TIAN Chunying, WANG Hongwu
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
关键词:
生化汤; 缩宫素; 产后出血; Meta分析
Keywords:
decoction; oxytocin; postpartum hemorrhage; Meta-analysis
分类号:
R271.43
DOI:
10.12174/j.issn.2096-9600.2026.03.19
文献标志码:
A
摘要:
目的通过Meta分析，系统评价生化汤联合缩宫素治疗产后出血的随机对照试验。 方法检索PubMed、Medline、CNKI、万方、CBM及VIP等数据库，收集以往至2021年3月底发表的有关试验，提取符合标准的数据。 结果共有26篇满足纳入标准，全部纳入病例总数为3367例，其中包括生化汤联合缩宫素组1864例患者，其他对照组1863例患者。Meta分析发现治疗产后出血中，生化汤联合缩宫素组有效率高于其他对照组（OR=6.74，95%CI：3.86～11.75，P＜0.000 01，I2=0%＜50%），总体效应z=6.72；生化汤联合缩宫素治疗之后产后2 h出血量明显少于其他疗法（MD=-65.76，95%CI：-78.84～-33.21，P＜0.000 01），产后24 h出血量明显少于其他疗法（MD=-89.67，95%CI：-95.52～-83.83，P＜0.000 01）；生化汤联合缩宫素治疗之后产后出血天数明显少于其他疗法（MD=-4.33，95%CI：-5.68～-2.98，P＜0.000 01）；生化汤联合缩宫素治疗之后子宫复缩体积明显小于其他疗法（MD=-8.84，95%CI：-36.42～-18.75，P＜0.000 01）；使用生化汤联合缩宫素疗法治疗的第三产程时间明显缩短（MD=-3.73，95%CI：-4.16～-3.29，P＜0.000 01）；以上差异均有统计学意义。 结论该治疗方式相对于其他疗法而言更值得在妇科临床上广泛应用。
Abstract:
ObjectiveTo systematically evaluate the efficacy of Shenghua decoction combined with oxytocin in the treatment of postpartum hemorrhage through a Meta-analysis of randomized controlled trials. MethodsPubMed, Medline, CNKI, Wanfang, CBM, and VIP databases were searched to collect relevant trials published from the inception of each database up to March 2021 to extract the data that met the inclusion criteria. ResultsA total of 26 studies met the inclusion criteria, encompassing 3,367 patients, among them, these included 1,864 patients in the Shenghua decoction combined with oxytocin group and 1,863 patients in the control groups. The Meta-analysis revealed that in the treatment of postpartum hemorrhage, the combination therapy showed a significantly higher response rate compared to the control groups (OR = 6.74, 95% CI:3.86-11.75, P<0.000 01, I?=0%<50%), and the overall effect size was Z=6.72. Furthermore, the combination therapy significantly reduced blood loss at 2 hours postpartum (MD=-65.76, 95% CI:-78.84 - -33.21), P<0.000 01) and at 24 hours postpartum (MD = -89.67, 95% CI:-95.52 - -83.83, P<0.000 01) compared to other interventions. The duration of postpartum bleeding was also significantly shorter in the combination group (MD =-4.33, 95% CI:-5.68 - -2.98), P<0.000 01). In addition, uterine involution volume was significantly smaller following treatment with Shenghua decoction and oxytocin (MD = -8.84, 95% CI:-36.42 - -18.75), P<0.000 01). Finally, the duration of the third stage of labor was significantly shortened in the combination therapy group (MD = -3.73, 95%CI:-4.16 - -3.29, P<0.000 01). All of the above differences were statistically significant. ConclusionThis therapeutic approach is more worthy of widespread clinical application in gynecology compared to other treatments.

相似文献/References:

[1]杨晓菊,裴永胜.益母草注射液联合缩宫素在剖宫产术中及术后出血中的应用效果观察[J].西部中医药,2014,27(07):91.
　YANG Xiaoju,PEI Yongsheng.Observation on the Application of YiMuCao Injection and Oxytocin to Bleeding in and after the Surgery of Cesarean Section[J].Western Journal of Traditional Chinese Medicine,2014,27(03):91.
[2]杨春梅.生化汤合失笑散联合常规西药治疗流产后出血40例[J].西部中医药,2015,28(08):123.

备注/Memo

备注/Memo:
国家重点基础研究发展计划（973计划）项目（2011CB505406）。周密（1996—），女，在读博士研究生。研究方向：循证医学。
更新日期/Last Update: 2026-03-15