[1]何力,吴苏宁,郭思佳,等.清源生化汤治疗四肢开放性骨折创面感染的疗效及其对相关炎症因子水平的影响[J].西部中医药,2022,35(07):61-64.[doi:10.12174/j.issn.2096-9600.2022.07.16]
　HE Li,WU Suning,GUO Sijia,et al.Clinical Effects of Qingyuan Shenghua Tang in Treating Wound Infection of Open Fracture of Extremities and Its Influence on the Levels of the Associated Inflammatory Factors[J].Western Journal of Traditional Chinese Medicine,2022,35(07):61-64.[doi:10.12174/j.issn.2096-9600.2022.07.16]
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清源生化汤治疗四肢开放性骨折创面感染的疗效及其对相关炎症因子水平的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年07期
页码:
61-64
栏目:
出版日期:
2022-07-15

文章信息/Info

Title:
Clinical Effects of Qingyuan Shenghua Tang in Treating Wound Infection of Open Fracture of Extremities and Its Influence on the Levels of the Associated Inflammatory Factors
作者:
何力1, 吴苏宁1, 郭思佳1, 李春亮2
1.西宁市中医院，青海 西宁 810000
2.青海省人民医院
Author(s):
HE Li1, WU Suning1, GUO Sijia1, LI Chunliang2
1.Xining City Hospital of TCM, Xining 810000, China
2.Qinghai Provincial People's Hospital
关键词:
四肢开放性骨折; 创面感染; 白细胞介素; 细胞间黏附分子1; 血管细胞黏附分子1; 清源生化汤
Keywords:
open fracture of extremities; wound infection; interleukin; ICAM-1; VCAM-1
分类号:
R264
DOI:
10.12174/j.issn.2096-9600.2022.07.16
文献标志码:
B
摘要:
目的探讨清源生化汤治疗四肢开放性骨折创面感染的疗效及其对白细胞介素6（interleukin-6，IL-6）、白细胞介素8（interleukin-8，IL-8）、细胞间黏附分子1（intercellular adhesion molecule-1，ICAM-1）、血管细胞黏附分子1（vascular cell adhesion molecule-1，VCAM-1）水平的影响。 方法将81例四肢开放性骨折创面感染患者采用随机数字表法分为对照组40例和观察组41例。对照组予常规治疗，观察组在对照组治疗的基础上口服清源生化汤。治疗7天后观察两组患者疗效，记录创面肉芽组织生长时间、感染控制时间及创面愈合时间，并测定两组患者治疗前后血清IL-6、IL-8、ICAM-1、VCAM-1水平，观察治疗期间不良反应发生情况。 结果观察组总有效率为87.80%，高于对照组的70.00%，差异有统计学意义（P＜0.05）；观察组创面肉芽组织生长时间、感染控制时间及创面愈合时间均较对照组缩短，差异有统计学意义（P＜0.05）；治疗后两组患者血清IL-6、IL-8、ICAM-1、VCAM-1水平均较治疗前降低，观察组低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为7.32%，对照组为2.50%，两组比较差异无统计学意义（P＞0.05）。 结论清源生化汤可有效促进四肢开放性骨折创面感染患者康复，缓解机体炎症反应，提高临床疗效，且安全可靠。
Abstract:
ObjectiveTo explore clinical effects of Qingyuan Shenghua Tang in treating wound infection of open fracture of extremities and its influence on the levels of IL-6, IL-8, ICAM-1 and VCAM-1. MethodsAll 81 patients were divided into 40 cases of the control group and 41 cases of the observation group according to random number table method. The control group accepted conventional therapy, and the observation group took Qingyuan Shenghua Tang based on conventional therapy. To observe therapeutic effects after seven days of treatment, to record growth time of granulation tissue, infection control time and wound closure time, to detect the levels of IL-6, IL-8, ICAM-1 and VCAM-1 before and after treatment between both groups, to analyze the incidence of adverse reaction during therapeutic period. ResultsTotal effective rate of the observation group was 87.80%, higher than 70.00% of the control group, and the difference had statistical meaning (P<0.05); the observation group was shorter than the control group in growth time of granulation tissue, infection control time and wound closure time, and the difference was statistically significant (P<0.05); after treatment, the levels of IL-6, IL-8, ICAM-1 and VCAM-1 of both groups were lower than these before treatment, the observation group was lower than the control group, and the difference showed statistical meaning (P<0.05); the incidence of adverse reaction of the observation group was 7.32%, higher than 2.50% of the control group, and the difference had no statistical meaning (P>0.05). ConclusionQingyuan Shenghua Tang could effectively improve the recovery of the patients with wound infection of open fracture of extremities, relieve inflammatory reaction, raise clinical effects, which is safe and reliable.

备注/Memo

备注/Memo:
何力（1972—），男，主治医师。研究方向：创伤与关节疾病的诊治。青海省科技计划项目（2019-ZJ-7067）。
更新日期/Last Update: 2022-07-15