[1]刘曼曼,沈怡华,冯珍凤,等.滋月萃降糖方对2型糖尿病合并非酒精性脂肪性肝病患者血清胎球蛋白B水平及糖脂代谢的影响[J].西部中医药,2023,36(03):1-4.[doi:10.12174/j.issn.2096-9600.2023.03.01]
 LIU Manman,SHEN Yihua,FENG Zhenfeng,et al.Influence of Nourishing-pancreas Lowering-glucose Prescription on the Levels of Serum Fetuin B, Sugar-fat Metabolism in Patients with T2DM and NAFLD[J].Western Journal of Traditional Chinese Medicine,2023,36(03):1-4.[doi:10.12174/j.issn.2096-9600.2023.03.01]
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滋月萃降糖方对2型糖尿病合并非酒精性脂肪性肝病患者血清胎球蛋白B水平及糖脂代谢的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年03期
页码:
1-4
栏目:
出版日期:
2023-03-14

文章信息/Info

Title:
Influence of Nourishing-pancreas Lowering-glucose Prescription on the Levels of Serum Fetuin B, Sugar-fat Metabolism in Patients with T2DM and NAFLD
作者:
刘曼曼1, 沈怡华1, 冯珍凤1, 高俊凤2, 胡春平1, 严军1
1.上海市嘉定区中医医院内分泌科,上海 201899
2.上海中医药大学,上海 201203
Author(s):
LIU Manman1, SHEN Yihua1, FENG Zhenfeng1, GAO Junfeng2, HU Chunping1, YAN Jun1
1.Endocrinology Department, Jiading District TCM Hospital, Shanghai 201899, China
2.Shanghai University of TCM, Shanghai 201203, China
关键词:
2型糖尿病非酒精性脂肪肝肽球蛋白B滋膵降糖方
Keywords:
T2DMNAFLDFetuin-Bnourishing-pancreas lowering-glucose prescription
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2023.03.01
文献标志码:
A
摘要:
目的探讨二甲双胍片联合滋膵降糖方对初发2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者血清胎球蛋白B(Fetuin-B)水平及糖脂代谢的影响。 方法将T2DM合并NAFLD患者76例随机分为西药组(二甲双胍片)、联合组(二甲双胍片+滋膵降糖方),治疗12周。治疗前后采用酶联免疫吸附法测定(enzyme linked immunosorbent assay,ELISA)两组患者血清Fetuin-B水平,比较两组患者腹围(waist circumference,WC)、体质指数(body mass index,BMI)、糖化血红蛋白(glycosylated hemoglobin,HbAlc)、空腹血糖(fasting plasma glucose,FPG)、餐后2h血糖(2-hour postprandial blood glucose,2h PG)、空腹胰岛素(fasting insulin,FINS)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)及胰岛素抵抗指数(homeostasis model of insulin resistance index,HOMA-IR)、胰岛β细胞功能指数(HOMA-β)。 结果1)治疗后两组患者WC、BMI、HbA1c、FPG、2h PG、FINS、TG、LDL-C、HOMA-IR均较治疗前下降(P<0.05);HOMA-β较治疗前上升(P<0.05);血清Fetuin-B水平西药组与治疗前比较差异无统计学意义(P>0.05),联合组较治疗前下降(P<0.01)。2)治疗后联合组患者WC、HbA1c、FPG、2h PG、FINS、TG及HOMA-IR低于西药组(P<0.05),HOMA-β高于西药组(P<0.05);血清Fetuin-B水平低于西药组(P<0.01)。 结论滋膵降糖方协同二甲双胍片可降低T2DM合并NAFLD患者血清Fetuin-B水平及血糖血脂水平,改善患者胰岛素抵抗,调节糖脂代谢。
Abstract:
ObjectiveTo discuss the effects of nourishing-pancreas lowering-glucose prescription on the levels of serum Fetuin-B, and sugar-fat metabolism in patients with T2DM and NAFLD. MethodsAll 76 patients were randomized into Western medicine group (metformin tablets), combination group (metformin tablets+ nourishing-pancreas lowering-glucose prescription), for 12 weeks. To detect the levels of serum Fetuin-B in both groups by using ELISA method before and after the treatment, to compare WC, BMI, HbA1c, FBG, FINS, 2h PG, TC, TG, LDL-C, HDL-C, HOMA-IR and HOMA-β between both groups. Results1) After the treatment, WC, BMI, HbA1c, FPG, 2h PG, FINS, TG, LDL-C and HOMA-IR in the two groups were lowered compared with these before the treatment (P<0.05); HOMA-β was higher than that before the treatment (P<0.05); the difference had no statistical meaning when the levels of serum Fetuin-B in Western medicine group were compared with these before the treatment (P>0.05), and the combination group was reduced compared with before the treatment (P<0.01). 2)After the treatment, the improvements of WC, HbA1c, FPG, FINS, 2h PG and TG, HOMA-IR in the combination group were superior, HOMA-β was lower than that of Western medicine group (P<0.05), HOMA-β was higher than that in Western medicine group (P<0.05); the levels of Fetuin-B were lower than these of Western medicine group (P<0.01). ConclusionNourishing-pancreas lowering-glucose prescription and metformin could reduce the levels of Fetuin-B, blood glucose and blood lipid in patients with T2DM and NAFLD, improve IR and adjust glucose lipid metabolism.

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备注/Memo

备注/Memo:
刘曼曼(1987—),女,硕士学位,主治医师。研究方向:内分泌代谢性疾病的中医药防治。上海市进一步加快中医药事业发展三年行动计划(2018—2020年)[ZY(2018-2020)-FWTX-4011]。
更新日期/Last Update: 2023-03-15