[1]李萍芳.龙蛇九味汤联合坎地沙坦酯片对高血压患者Renin、AngⅡ与ALD的影响[J].西部中医药,2024,37(03):140-143.[doi:10.12174/j.issn.2096-9600.2024.03.28]
　LI Pingfang.Influence of Longshe Jiuwei Decoction Combined with Candesartan Cilexetil Tablets on Renin, Ang Ⅱ and ALD in Patients with Hypertension[J].Western Journal of Traditional Chinese Medicine,2024,37(03):140-143.[doi:10.12174/j.issn.2096-9600.2024.03.28]
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龙蛇九味汤联合坎地沙坦酯片对高血压患者Renin、AngⅡ与ALD的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年03期
页码:
140-143
栏目:
衷中参西
出版日期:
2024-03-15

文章信息/Info

Title:
Influence of Longshe Jiuwei Decoction Combined with Candesartan Cilexetil Tablets on Renin, Ang Ⅱ and ALD in Patients with Hypertension
作者:
李萍芳
淮南市新华医疗集团新华医院中医科，安徽 淮南 232052
Author(s):
LI Pingfang
TCM Department, Xinhua Hospital of Xinhua Medical Group, Huainan 232052, China
关键词:
高血压; 肾素; 血管紧张素Ⅱ; 醛固酮; 龙蛇九味汤; 坎地沙坦酯片
Keywords:
hypertension; renin; AngⅡ; ALD; decoction; candesartan cilexetil tablets
分类号:
R544.1
DOI:
10.12174/j.issn.2096-9600.2024.03.28
文献标志码:
B
摘要:
目的研究龙蛇九味汤联合坎地沙坦酯片治疗高血压的疗效及其对患者肾素（Renin）、血管紧张素Ⅱ（angiotensin Ⅱ，AngⅡ）及醛固酮（aldosterone，ALD）水平的影响。 方法将高血压患者99例按照随机数字表法分为观察组（50例，予龙蛇九味汤联合坎地沙坦酯片治疗）和对照组（49例，予坎地沙坦酯片治疗）。比较两组治疗效果，观察两组患者治疗前后甘油三酯（triglyceride，TG）、总胆固醇（total cholesterol，TC）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）及低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）水平。检测两组患者治疗前后血浆Renin、AngⅡ及ALD水平。 结果观察组疗效优于对照组（P＜0.05）；治疗后观察组TG、TC、LDL-C及血压晨峰值、收缩压、舒张压以及血浆Renin、AngⅡ、ALD均低于对照组（P＜0.05），HDL-C高于对照组（P＜0.05）。 结论龙蛇九味汤联合坎地沙坦酯有助于纠正高血压患者血脂紊乱情况，提高治疗效果，可能与其降低Renin、AngⅡ及ALD水平，调节肾素-血管紧张素-醛固酮系统有关。
Abstract:
ObjectiveTo study clinical effects of Longshe Jiuwei decoction and candesartan cilexetil tablets in the treatment of hypertension and its influence on the levels of Renin, AngⅡ and ALD. MethodsA total of 99 patients were allocated to the observation group (50 cases, oral administration of Longshe Jiuwei decoction and candesartan cilexetil tablets) and the control group (49 cases, oral administration of candesartan cilexetil tablets) according to random number table method. To compare clinical effects between both groups, to observe the levels of TG, TC, HDL-C and LDL-C before and after the treatment in the two groups. To detect the levels of plasma Renin, AngⅡ and ALD before and after the treatment in the two groups. ResultsClinical effects of the observation group were better than those of the control group (P<0.05); after the treatment, the levels of TG, TC, LDL-C, morning peak blood pressure, SBP, DBP, plasma Renin, AngⅡ and ALD of the observation group were lower than those of the control group (P<0.05), the levels of HDL-C higher than those of the control group (P<0.05). ConclusionLongshe Jiuwei decoction and candesartan cilexetil tablets could help correct lipid disorders in hypertensive patients, raise therapeutic effects, which might be related to reducing the levels of plasma Renin, AngⅡ and ALD and adjusting RAAS.

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备注/Memo

备注/Memo:
李萍芳（1974—），女，主治医师。研究方向：内科系统疾病的中医药防治。E-mail：lipingfang2021623@163.com。沈阳市中青年科技创新人才支持计划项目（RC200085）。
更新日期/Last Update: 2024-03-15