肺炎一号合剂对社区获得性肺炎儿童免疫功能和临床预后的影响-《西部中医药》

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Title:: Influence of "Pneumonia No. 1 Mixture" on Immune Function and Clinical Prognosis of Children with Community-acquired Pneumonia

作者:: 韦又嘉, 李雅殿, 陆莹华, 韦辉连; 河池市第一人民医院药学部，广西河池 546300

Author(s):: WEI Youjia, LI Yadian, LU Yinghua, WEI Huilian; Department of Pharmacy, Hechi First People's Hospital, Hechi 546300, China

关键词:: 儿童社区获得性肺炎; 肺炎一号合剂; 免疫功能; 炎性因子; 中西医结合

Keywords:: children with community-acquired pneumonia; pneumonia No. 1 mixture; immunologic function; inflammatory factor; integrated traditional Chinese and Western medicine

分类号:: R563.1

DOI:: 10.12174/j.issn.2096-9600.2024.04.24

文献标志码:: B

摘要:: 目的分析中药制剂“肺炎一号合剂”对社区获得性肺炎（community-acquired pneumonia，CAP）儿童免疫功能和临床预后的影响。方法选择CAP患儿180例，随机分为观察组和对照组，各90例。对照组给予西医基础治疗，观察组在对照组的基础上增服肺炎一号合剂，连续治疗4周。对比两组临床疗效、症状消失时间和不良反应发生情况；比较两组治疗前后CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺、炎性因子白细胞介素6（interleukin-6，IL-6）、肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）和C反应蛋白（C-reactive protein，CRP）水平、肺通气功能指标氧合指数（oxygenation index，OI）、肺动态顺应性（pulmonary dynamic compliance，Cdyn）和呼吸做功量（work of breathing，WOB）水平。结果观察组总有效率［94.44%（85/90）］高于对照组［84.44%（76/90）］（P＜0.05）；观察组症状消失时间均短于对照组（P＜0.05）；治疗后，两组CD8⁺水平较治疗前降低，CD3⁺、CD4⁺、CD4⁺/CD8⁺水平较治疗前升高，且观察组免疫功能改善较对照组更为显著（P＜0.05）；治疗后，两组IL-6、CRP及TNF-α均较治疗前下降，且观察组炎性因子水平均低于对照组（P＜0.05）；治疗后，两组OI、Cdyn及WOB水平均较治疗前升高，且观察组肺通气指标水平在治疗后均高于对照组（P＜0.05）。结论在西医抗生素治疗的基础上联合肺炎一号合剂治疗儿童CAP疗效确切，可明显缩短病程，改善患者免疫功能，降低血清炎性因子水平，改善肺通气功能。

Abstract:: ObjectiveTo analyze the effects of TCM preparation "pneumonia No. 1 mixture" on immune function and clinical outcome of children suffering community-acquired pneumonia (CAP). MethodsAll 180 CAP children were randomized into the observation group and the control group with 90 cases in each group. The control group was treated by basic therapy of Western medicine, and the observation group took pneumonia No. 1 mixture on the foundation of the therapy the control group accepted, they were treated for four consecutive weeks. To compare clinical effects, symptom disappearing time and the incidence of adverse reaction between both groups; to compare the levels of CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺, inflammatory factors including IL-6, TNF-α and CRP, as well as the indicators of pulmonary ventilatory function such as OI, Cdyn and WOB before and after the treatment between both groups. ResultsTotal effective rate of the observation group was [94.44%(85/90)], higher than [84.44%(76/90)] of the control group (P<0.05); symptom disappearing time of the observation group was shorter than that of the control group (P<0.05); after the treatment, the levels of CD8⁺ were lowered in the two groups than before the treatment, the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ were increased than before the treatment, and the improvement of immunologic function of the observation group was more evident than that of the control group (P<0.05); after the treatment, the levels of IL-6, CRP and TNF-α were reduced than before the treatment, and the levels of inflammatory factors of the observation group were lower than these of the control group (P<0.05); after the treatment, the levels of OI, Cdyn and WOB were raised than before the treatment in the two groups, and the observation group was higher than the control group in the levels of the indicators of pulmonary ventilation function after the treatment (P<0.05). ConclusionOn the foundation of antibiotics in Western medicine, its combination with pneumonia No. 1 mixture could obtain definite clinical effects in the treatment of CAP children, it could obviously shorten the course of the disease, improve the patients' immunologic function, reduce the levels of serum inflammatory factors and improve pulmonary ventilation function.

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

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