探讨糖调节受损与颈动脉中膜厚度的关系及意义-《西部中医药》

文章信息/Info

Title:: On Relationship between Impaired Glucose Regulation and Carotid Intima-Media Thickness and Their Meanings

Author(s):: GAO Dong-ling, WEI Yan-hong; Endocrinology Department of Baiyin Second People′s Hospital, Baiyin 730900, China

Keywords:: impaired glucose regulation; carotid intima-media thickness; risk factors

摘要:: 目的：探讨糖调节受损（IGR）患者颈动脉中膜厚度(IMT)增加的危险因素。方法：统计76例IGR患者及51例正常糖耐量(NGT)人的年龄、性别、体质量、血压、测空腹血糖、餐后2小时血浆血糖(OGTT)、空腹甘油三酯、总胆固醇(TC)、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C），并计算体重指数，检测颈动脉中膜厚度(IMT)值。分析不同IGR患者IMT值的差异性。结果：IGT组及IFG+IGT组IMT分别与IFG组及NGT组比较有显著差异(P＜0.05)，其他各组比较无显著差异。年龄、收缩压、TC、LDL-C、2hPG是IMT的危险因素。结论：与NGT组比较，IGT组、IFG+IGT组患者早期已存在明显的动脉粥样硬化(AS)及与之相关的危险因素。

Abstract:: Objective: To explore the risk factors of carotid intima-media thickness(IMT) in patients with impaired glucose regulation (IGR). Method: Conditions of seventy-six patients with IGR and fifty-one persons with normal glucose tolerance(NGT) were statistically analyzed, which contained the age, gender, body weight, blood pressure, fasting blood-glucose, 2 hours postprandial plasma glucose (OGTT), fasting triglyceride, total cholesterol (TC), low density lipoprotein(LDL-C), high density lipoprotein (HDL-C). Meanwhile body mass index was calculated and carotid intima-media thickness (IMT) was detected. IMT of patients with IGR were analyzed. Result: IGT group, IFG+IGT group were compared with IFG group and NGT group, the comparisons in IMT showed remarkable difference(P＜0.05), comparisons among other groups showed no significant difference. Age, systolic pressure, TC, LDL-C and 2hPG were risk factors of IMT. Conclusion: Patients with IGT or IFG+IGT manifested obvious atherosclerosis and associated risk factors in early time.