[1]盛 丽,张宝洲,强 群,等.彩超监测肠系膜上动脉流速对大鼠粘连性肠梗阻的诊断及茴香枳术汤疗效的判定*[J].西部中医药,2012,25(10):115-118.
　SHENG Li,ZHANG Bao-zhou,QIANG Qun,et al.Evaluation on Clinical Efficacy of HuiXiang ZhiZhuTang and Diagnosis of Adhesive Ileus in Rats through Colour Doppler Ultrasound Monitoring Superior mesenteric Artery Flow Velocity[J].Western Journal of Traditional Chinese Medicine,2012,25(10):115-118.
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彩超监测肠系膜上动脉流速对大鼠粘连性肠梗阻的诊断及茴香枳术汤疗效的判定*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年10期
页码:
115-118
栏目:
出版日期:
2012-10-15

文章信息/Info

Title:
Evaluation on Clinical Efficacy of HuiXiang ZhiZhuTang and Diagnosis of Adhesive Ileus in Rats through Colour Doppler Ultrasound Monitoring Superior mesenteric Artery Flow Velocity
文章编号:
1004-6852(2012)10-0115-03
作者:
盛 丽，张宝洲，强 群，王维斌，唐晓勇△
甘肃省中医院，甘肃 兰州 730050
Author(s):
SHENG Li, ZHANG Bao-zhou, QIANG Qun, WANG Wei-bin, TANG Xiao-yong△
Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
肠梗阻; 粘连性; 肠系膜上动脉流速; 茴香枳术汤
Keywords:
ileus;  adhesive;  Wsuperior mesenteric artery flow velocity;  HuiXiang ZhiZhuTang
分类号:
R574.2
文献标志码:
B
摘要:
目的：探讨彩超监测肠系膜上动脉流速对粘连性肠梗阻的诊断及药物疗效的判定价值。方法：72只SPF级(雌雄各半)Wistar大鼠，随机分为正常组、模型组、大承气汤(DS)组、茴香枳术汤(HX-S)低剂量组、中剂量组和高剂量组，除正常组，其余组大鼠按照浆膜剥脱法复制大鼠粘连性肠梗阻模型，造模成功后各组分别检测肠系膜上动脉流速及肠梗阻程度，并对其关系进行统计学分析；各组分别给予生理盐水、DS、HX-S低、中、高剂量灌胃，治疗后第3、7天分别应用彩色多普勒观察大鼠肠系膜上动脉峰值流速。结果：模型组中肠系膜上动脉(superior mesenteric artery，SMA)收缩期峰值流速与肠梗阻严重程度呈正相关(r=0.418，P＜0.01)；治疗后第3、7天，DS组、HX-S低、中、高剂量组与模型组比较，肠系膜上动脉收缩期峰值流速均明显下降(P＜0.05)，各治疗组比较，HX-S高剂量组效果较显著。结论：应用高频彩超监测肠系膜上动脉流速对大鼠粘连性肠梗阻的诊断及药物疗效的判定有一定的价值。
Abstract:
Objective: To explore the diagnosis of superior mesenteric artery (SMA) for adhesive ileus and the value of medicine. Method: Seventy-two rats were randomly allocated to normal group, model group, DaChengQiTang group (DS), low, moderate and high dosage groups of HuiXiang ZhiZhuTang(HX-S). Except normal group, the rats in other groups were successfully established the models with membrane stripping method and then SMA flow velocity, the degrees of intestinal obstruction and their relationship were analyzed statistically; meanwhile, the rats in six groups received intragastric administration of physiological saline, DS, low, moderate and high dosage of HX-S. At the third and seventh day after treating, SMA flow velocity was observed with color Doppler ultrasound. Result: SMA flow velocity was positively related to the degree of intestinal obstruction in model group (r=0.418, P＜0.01); SMA flow velocity decreased obviously at the third and seventh day after treating when DS group, low, moderate and high dosage groups of HX-S were compared with model group (P＜0.05). High dosage group of HX-S obtained remarkable effects when different groups were compared. Conclusion: High-frequency color Doppler ultrasound monitoring SMA flow velocity manifests certain value for the diagnosis of adhesive ileus in rats and the effects of medicine.

参考文献/References:

［1］ 王东红，李亮，盛丽，等.浆膜剥脱法建立大鼠粘连性不完全性肠梗阻模型［J］.中国普外基础与临床杂志，2011，18(4)：384-390.
［2］ 吴在德，吴肇汉，郑树，等.外科学［M］.北京：人民卫生出版社，2004：480.
［3］ 侯立军.中西医结合治疗粘连性肠梗阻60例［J］.河北中医，2009，31(7):1026-1027.
［4］ 黄永炼.中西医结合治疗术后粘连性肠梗阻的临床研究［J］.中国医药科学，2012，2(11)：74.
［5］ 姬静，陈丽波，孙志霞，等.B型超声在肠梗阻诊断中的应用［J］.中国实验诊断学，2007，11(9)：1258-1259.
［6］ 唐晓勇，王东红，盛丽，等.茴香枳术汤治疗术后粘连性肠梗阻30例临床观察［J］.中国社区医师，2010，12(7)：6.
［7］ 柳渊洁，李亮，王东红，等.茴香枳术汤对大鼠粘连性肠梗阻组织SOD，MDA及病理变化的影响［J］.中国实验方剂学杂志，2011，1(17)：165-168.
［8］ Haglund U，Osterberg J.Local consequences of reper-fusion in the gut，pierce and robert mathie：ischemia-reperfusion injury［M］.Oxford UK，Blackwell Science，1999，23(2)：65-69.
［7］ 刘诚聪，李世宽，王培戈，等.泛影葡胺对粘连性小肠梗阻的临床疗效［J］.中国普通外科杂志，2010，19(4)：68-71.
［10］ 陈主初，郭恒怡，王树人.病理生理学［M］.北京：人民卫生出版社，2005：318.
［11］ 金伟飞，王仲迪.复方大承气汤灌胃促进腹部手术后胃肠功能恢复的疗效观察［J］.现代中西医结合杂志，2004，13(10)：1301-1302.
［12］ 张宇，刘晓虹，蒋敦厚，等.复方大承气汤治疗粘连性肠梗阻54例疗效观察［J］.新中医，2007，39(1)：13-14.
［11］ Thomson AB，Keelan M，THiesen A，et al.Small bowel review：normal physiology part 2［J］.Digestive Diseases and Sciences，2001，46(12)：2588-2607.
［14］ 丁连翠，路新国.药膳“益脾饮”对脾气虚证大鼠血液流变学及血浆TXB-2、6-keto-PGF-1α的影响［J］.西部中医药，2012，25(5):33-35.
［15］ 殷静先.白术药理研究进展［J］.时珍国医国药，2000，11(6)：572.
［16］ 宿树兰.积壳的研究进展［J］.中药材，2001，24(3)：222-224.
［17］ 田冬霞.四逆散合越鞠丸加减治疗胆汁反流性胃炎96例［J］.甘肃中医，2010，23(8):35-36.
［18］ 董华泽，王艳苹，袁新松，等.小茴香对小鼠免疫功能的影响[J］.安徽农业科学，2009，37(27)：13419-13420.
［19］ 付梅红，朱东海，方婧，等.苍术的化学、分子生药学和药理学研究进展［J］.中国中药杂志 2009，34(20)：2669-2672.
［20］ 鲁汉兰，余诚，邓三平.香附炮制后对小鼠消积化滞作用的影响(简报)［J］.中国中药杂志，1999，24(7)：409.
［21］ 刘林亚.中药桂枝、肉桂化学成份的对比研究［J］.四川中医，2001，19(1)：17-19.

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备注/Memo

备注/Memo:
收稿日期：2012-04-287 *基金项目：甘肃省自然科学研究基金计划项目(编号096RJZA042) 作者简介：盛丽(1960—)，女，主任医师。研究方向：疾病-脉象-彩色多普勒血流动力学的相关性研究。 △通讯作者：唐晓勇(1968—)，男，主任医师，甘肃省普外专业委员会腹腔镜学组委员。研究方向：胃肠和周围血管的微创治疗。
更新日期/Last Update: 1900-01-01