[1]李晶,刘小军,赵达△.康莱特软胶囊联合化疗治疗晚期卵巢癌的临床研究[J].西部中医药,2013,26(01):1-4.
　LI Jing,LIU Xiaojun,ZHAO Da.Clinical Study on KangLaiTe Soft Capsule and Chemotherapy in Treating Ovarian Cancer at Advanced Stage[J].Western Journal of Traditional Chinese Medicine,2013,26(01):1-4.
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康莱特软胶囊联合化疗治疗晚期卵巢癌的临床研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年01期
页码:
1-4
栏目:
出版日期:
2013-01-15

文章信息/Info

Title:
Clinical Study on KangLaiTe Soft Capsule and Chemotherapy in Treating Ovarian Cancer at Advanced Stage
文章编号:
1004-6852(2013)01-0001-04
作者:
李晶1，刘小军2，赵达2△
1 兰州市第一人民医院妇产科，甘肃 兰州 730050；
2 兰州大学第一医院
Author(s):
LI Jing1, LIU Xiaojun2, ZHAO Da2△
1 Department of Obstetrics and Gynecology in the First People忆s Hospital of Lanzhou, lanzhou 730050, China;
2 The First Hospital of Lanzhou University
关键词:
卵巢癌; 晚期; 康莱特; 化疗
Keywords:
ovarian cancer; advanced stage;  KangLaiTe soft capsule;  chemotherapy
分类号:
R737.31
文献标志码:
A
摘要:
目的：评价康莱特软胶囊联合化疗治疗晚期卵巢癌的疗效、毒副反应及对患者生活质量的影响。方法: 将 65 例晚期卵巢癌患者随机分为康莱特组和对照组。康莱特组采用 TC 方案（紫杉醇 + 卡铂）化疗联合康莱特软胶囊治疗，对照组仅采用 TC 方案化疗，观察近期疗效、毒副反应、生活质量及血清CA125正常化比率。结果:康莱特组有效率为 42.4%,疾病控制率 75.8%；对照组有效率为 40.6%，疾病控制率 62.5%。康莱特组有效率及疾病控制率均高于对照组,但 2 组比较差异无统计学意义(P＞0.05)；康莱特组在总体健康评分、卵巢癌 V28 评分、部分症状改善方面优于对照组；康莱特组骨髓抑制、恶心、呕吐、疲乏、肌肉关节疼痛等毒副反应发生率低于对照组。结论:康莱特软胶囊联合化疗治疗晚期卵巢癌化疗有效率高，化疗相关毒副反应轻,能有效提高患者生活质量。
Abstract:
Objective: To explore curative effects and toxicity of KangLaiTe soft capsule and chemotherapy in the treatment for ovarian cancer at advanced stage and life its influence on quality of the patients. Method: All 65 patients with ovarian cancer at advanced stage were randomized into KangLaiTe group and the control group.KangLaiTe group received TC plan (paclitaxel+carboplatin) and KangLaiTe soft capsule while the control group TC plan only. Therapeutic effect in the near future, toxicity, life quality and ratio of serum CA125 normalization were observed. Result: The effective rate of KangLaiTe group was 42.4% , control rate of disease 75.8% , higher than 40.6% and 62.5% of the control group. The differences of the comparisons showed no statistical meaning (P＞ 0.05);KangLaiTe group was superior to the control group in total health scale, V28 scale of ovarian cancer, improvements of symptom; KangLaiTe group was lower than the control group in incidence of adverse reaction and toxicity which manifested arrest of bone marrow, nausea, vomiting, lassitude, muscular and joint pain, etc. Conclusion: KangLaiTe soft capsule and chemotherapy are effective in treating ovarian cancer at advanced stage, could alleviate toxicity induced by chemotherapy and improve life quality of patients effectively.

参考文献/References:

［1］ Hunn J，Rodriguez GC.Ovarian Cancer：etiology，riskfactors，and epidemiology［J］.Clinical obstetrics andgynecology，2012，55(1)：3-23.
［2］ Du Bois A，Lück HJ，Meier W，et al.A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian
cancer［J］.Journal of the National Cancer Institute，2003，95(17)：1320-1329.
［3］ Lu Y，Wu LQ，Dong Q，et al.Experimental study on the effect of KangLaiTe induced apoptosis of human hepatoma carcinoma cell HepG2［J］.Hepatobiliary Pancreat Dis Int，2009，8(3)：267-272.
［4］ 梁铁军，秦成勇，谭艳蓉，等.康莱特抑制肝癌细胞 HepG2增殖的实验研究［J］.中国肿瘤临床，2006，33(13)：743-746.
［5］ Qi F，Li A，Inagaki Y，et al.Chinese herbal medicinesas adjuvant treatment during chemo-or radio-therapy for cancer［J］.Bioscience trends，2010，4(6)：297-307.
［6］ 乐杰.妇产科学［M］.7 版.北京：人民卫生出版社，2008：125.
［7］ Burger R，Brady M，Bookman M，et al.Phase Ⅲ trial of bevacizumab(BEV)in the primary treatment of advanced epithelial ovarian cancer(EOC)，primary peritoneal cancer(PPC)or fallopian tube cancer(FTC)：a gynecologic oncology group study［J］.J Clin Oncol，2010，28(18 suppl)：8-13.
［8］ 刘小军，周永宁，赵达.贝伐单抗治疗恶性肿瘤不良反应的策略［J］.国际肿瘤学杂志，2011，38(9)：711-714.
［9］ Hanahan D，Weinberg RA.Hallmarks of cancer：the next generation［J］.Cell，2011，144(5)：646-674.
［10］李明花，金佳鹤.施志明治疗卵巢癌的经验［J］.2008，30（9）：902-903.
［11］黄毅超，何志江，刘云军，等.紫杉醇联合顺铂腹腔给药治疗52 例晚期卵巢癌效果分析［J］.中国现代医生，2012，6（21）：33-34．
［12］吴鹏，郑智.卵巢癌复发预测研究进展［J］.中国现代医生，2012，6(4):29-30.
［13］何志芳.炎症与妇科恶性肿瘤关系的研究进展［J］.中国现代医生，2011，5(22):15-16

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备注/Memo

备注/Memo:
收稿日期：2012-08-20
作者简介：李晶(1965—)，女，副主任医师，中华医学会甘肃分会围产医学专业委员会委员，中华医学会甘肃分会辅助生殖医学专业委员会委员。研究方向：妇产科疾病的诊治。
△通讯作者：赵达(1965—)，男，主任医师，副教授，中国抗癌协会临床肿瘤专业委员会(CSCO)会员，甘肃省抗癌协会理事，甘肃省抗癌协会分子靶向治疗专业委员会主任委员，甘肃省抗癌协会大肠癌专业委员会委员，甘肃省抗癌协会胃癌专业委员会委员。研究方向：消化系统、呼吸系统、妇科、乳腺及男性泌尿系统恶性实体瘤的诊治。
更新日期/Last Update: 2013-01-14