[1]杨宏武,李亮,唐晓勇△.茴香枳术汤对实验性大鼠粘连性肠梗阻组织NO、DAO的影响[J].西部中医药,2013,26(03):28-30.
 YANG Hongwu,LI Liang,TANG Xiaoyong.Effects of HuiXiang ZhiZhuTang on NO and DAO of Experimental Rats with Adhesive Intestinal Obstruction[J].Western Journal of Traditional Chinese Medicine,2013,26(03):28-30.
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茴香枳术汤对实验性大鼠粘连性肠梗阻组织NO、DAO的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年03期
页码:
28-30
栏目:
出版日期:
2013-03-15

文章信息/Info

Title:
Effects of HuiXiang ZhiZhuTang on NO and DAO of Experimental Rats with Adhesive Intestinal Obstruction
文章编号:
1004-6852(2013)03-0028-03
作者:
杨宏武1李亮2唐晓勇2△
1 甘肃中医学院,甘肃 兰州 730000;2 甘肃省中医院
Author(s):
YANG Hongwu1, LI Liang2, TANG Xiaoyong2△
1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Gansu Province Hospital of Traditional Chinese Medicine
关键词:
肠梗阻粘连性茴香枳术汤组织一氧化氮二胺氧化酶
Keywords:
intestinal obstruction adhesive HuiXiang ZhiZhuTang tissue NO DAO
分类号:
R285.6
文献标志码:
A
摘要:
目的:观察茴香枳术汤对大鼠粘连性肠梗阻组织一氧化氮(NO)含量、二胺氧化酶(DAO)活性的影响。方法:制备大鼠粘连性肠梗阻模型,随机分为正常组,模型组,大承气汤组,茴香枳术汤低、中、高剂量组。给予相应药物治疗,分别于治疗后第 3、5、7 天,共 3 个时间点,每时间点 6 只,切取病变肠管匀浆,取上清液,放免法测定组织 NO 含量与 DAO 活性。结果:与正常组比较,模型组组织 NO 含量增加(P<0.05),DAO 活性下降(P<0.05);与模型组比较,大承气汤组、茴香枳术汤低剂量组、茴香枳术汤中剂量组和茴香枳术汤高剂量组组织 NO 含量显著下降(P<0.05),DAO 活性增加(P<0.05)。结论:茴香枳术汤对粘连性肠梗阻具有良好的治疗作用,其作用机制与保护肠屏障功能有关。
Abstract:
Objective: To observe the effects of HuiXiang ZhiZhuTang on NO contents and DAO activity of rats with adhesive intestinal obstruction. Method: Models were established and randomized into normal group,model group, Da ChengQiTang group, low, moderate and high dose groups of HuiXiang ZhiZhuTang. The rats were given with corresponding medicine, NO content and DAO activity were measured with radioimmunoassay after treating at the 3 rd, 5 th and 7 th day. Result: Compared with normal group, NO content increased and DAO activity decreased in model group (P<0.05); compared with model group, NO content lowered and DAO activity increased in Da ChengQiTang group, low, moderate and high dose groups of HuiXiang ZhiZhuTang (P<0.05). Conclusion: HuiXiang ZhiZhuTang is effective in treating adhesive intestinal obstruction, the mechanism might be related to protect intestinal barrier.

参考文献/References:

[1] 钱永坤.成年人肠梗阻的病因及治疗分析[J].江苏医药,2005,31(1):44-45. [2] 刘付宝,刘生光,何长林,等.一氧化氮预防腹膜粘连的实验研究[J].蚌埠医学院学报,2004,29(1):5-8. [3] 陈军亮,樊志敏.肠屏障功能常用血清学检测现状及进展[J].结直肠肛门外科,2009,15(3):207-208. [4] 唐晓勇,王东红,盛丽,等.茴香枳术汤治疗术后粘连性肠梗阻 30 例临床观察[J].中国社区医师:医学专业,2010,12(7):86. [5] 王东红,李亮,盛丽,等.浆膜剥脱法建立大鼠粘连性不完全性肠梗阻模型[J].中国普外基础与临床杂志,2011,18(4):384-390. [6] 曹海军,陈李华.肠屏障功能障碍的研究现状与展望[J].国际消化病杂志,2007,27(6):436-437. [7] 杨武,肖桦,黄永坤.肠屏障功能障碍发生机制与诊断治疗[J].实用儿科临床杂志,2007,22(19):1514-1518. [8] 于晓明,金宏,糜漫天.肠屏障功能的损伤与营养素防护[J].解放军预防医学杂志,2006,24(1):68-70. [9] Luk GD,Bayless TM,Baylin SB,et al.Plasma postheparin diamine oxidase sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat[J].J Clin Invest,1983,71(5):1308-1315. [10]中华医学会消化病学分会.肠屏障功能障碍临床诊治建议[J].中华消化杂志,2006,26(9):620. [11]柳渊洁,王东红,盛丽,等.茴香枳术汤对粘连性肠梗阻大鼠血浆 D- 乳酸的影响[J].西安交通大学学报:医学版,2011,32(5):640-642. [12]董华泽,王艳苹,袁新松,等.小茴香对小鼠免疫功能的影响[J].安徽农业科学,2009,37(27):13419-13420. [13] 宿树兰.积壳的研究进展[J].中药材,2001,24(3):222-224. [14]马向东,张磊,史建伟.益气润肠汤治疗结肠慢传输型便秘的疗效观察[J].中国现代医生,2008,46(16):91. [15]夏文晓,张学顺,梁彤.枳实和白术及其配伍药对的现代研究[J].中医药信息,2012,29(3):15-19. [16]付梅红,朱东海,方婧,等.苍术的化学、分子生药学和药理学研究进展[J].中国中药杂志,2009,34(20):2669-2672. [17]殷静先.白术药理研究进展[J].时珍国医国药,2000,11(6):572. [18]鲁汉兰,余诚,邓三平.香附炮制后对小鼠消积化滞作用的影响(简报)[J].中国中药杂志,1999,24(7):409. [19]刘林亚.中药桂枝、肉桂化学成份的对比研究[J].四川中医,2001,19(1):17-19. [20]盛丽,张宝洲,强群,等.彩超监测肠系膜上动脉流速对大鼠粘连性肠梗阻的诊断及茴香枳术汤疗效的判定[J].西部中医药,2012,25(10):115-118.

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备注/Memo

备注/Memo:
收稿日期:2012-10-20 作者简介:杨宏武(1969—),男,在职硕士研究生,主任医师。研究方向:肠道肿瘤的中西医结合诊治。 △通讯作者:唐晓勇(1968—),男,主任医师,甘肃省普外科专业委员会腹腔镜学组委员。研究方向:胃肠和周围血管病的微创治疗。
更新日期/Last Update: 2013-03-15