[1]李东峰,赵闻平,刘喜平△,等.半夏泻心汤含药血清对人胃癌腹膜转移细胞增殖的影响*[J].西部中医药,2014,27(01):14-16.
　LI Dongfeng,ZHAO Wenping,LIU Xiping,et al.Effects of BanXia XieXin Tang Medicated Serum on the Proliferation of Human Gastric Cancer Cells through Peritoneal Metastasis[J].Western Journal of Traditional Chinese Medicine,2014,27(01):14-16.
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半夏泻心汤含药血清对人胃癌腹膜转移细胞增殖的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年01期
页码:
14-16
栏目:
出版日期:
2014-01-14

文章信息/Info

Title:
Effects of BanXia XieXin Tang Medicated Serum on the Proliferation of Human Gastric Cancer Cells through Peritoneal Metastasis
文章编号:
1004-6852(2014)01-0014-03
作者:
李东峰1，赵闻平2，刘喜平3△，明海霞3，孙少伯3，张炜4
1 天水市中医医院急诊科，甘肃 天水 741000； 2 甘肃省军区干休所卫生所； 3 甘肃中医学院教育部“敦煌医学与转化”重点实验室； 4 兰州大学第一医院外科
Author(s):
LI Dongfeng1, ZHAO Wenping2, LIU Xiping3△, MING Haixia3, SUN Shaobo3, ZHANG Wei4
1 Emergency Department of Tianshui Municipal TCM Hospital, Tianshui 741000, China; 2 Health Center of Gansu Provincial Military Cadre Sanatorium; 3 Key Laboratory of Education Ministry ″Dunhuang Medicine and Translation″ from Gansu University of Traditional Chinese Medicine; 4 Surgical Department of Lanzhou University First Hospital
关键词:
人胃癌腹膜高转移潜能细胞株GC9811-P; 半夏泻心汤; 生长抑制
Keywords:
human gastric cancer cell line GC9811-P with high potential metastasis to peritoneum;  BanXia XieXin Tang;  growth inhibition
分类号:
R735.2
文献标志码:
A
摘要:
目的：研究半夏泻心汤含药血清对体外人胃癌腹膜高转移潜能细胞株GC9811-P增殖的影响。方法：采用血清药理学方法、MTT法及台盼兰染色法观察半夏泻心汤对GC9811-P细胞的敏感性及生长抑制作用。结果：半夏泻心汤含药血清对GC9811-P较为敏感，对其增殖有明显的抑制作用，且有显著的剂量-效应关系(P＜0.05)。结论：半夏泻心汤对GC9811-P细胞的增殖有一定的抑制作用，提示辛开苦降法可能是中医药防治胃癌腹膜转移的主要治法之一。
Abstract:
Objective: To study the influence of BanXia XieXin Tang medicated serum on the proliferation of human gastric cancer cell line GC9811-P with high potential metastasis. Methods: The sensitivity and inhibitory effects of BanXia XieXin Tang on GC9811-P cells were observed by serum pharmacological method, MTT assay and Trypan blue staining test. Results: BanXia XieXin Tang medicated serum is sensitivity to GC9811-P, and it could inhibit the proliferation of GC9811-P, which showed obvious dose-effects relation(P＜0.05). Conclusion: BanXia XieXin Tang could inhibit the proliferation of GC9811-P, which suggested that the method of opening with acrid drugs and downbearing with bitter ones might be one of main methods for TCM in the prevention of gastric cancer peritoneal metastasis.

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备注/Memo

备注/Memo:
收稿日期：2013-03-29*基金项目：国家自然科学基金项目(编号81260525)，甘肃省高校基本科研业务费专项基金(编号2011-3)作者简介：李东峰(1973—)，男，主治医师。研究方向：危重病症的中西医结合治疗。△通讯作者：刘喜平(1973—)，男，硕士研究生导师，教授，国家自然基金同行评议专家，中华中医药学会委员，第五批全国老中医药专家学术经验继承人。研究方向：敦煌医学及其治法与方剂配伍
更新日期/Last Update: 2014-01-15