[1]李彩东,梁云,张伟,等.珠芪复肝颗粒成型工艺研究[J].西部中医药,2014,27(02):41-43.
　LI Caidong,LIANG Yun,ZHANG Wei,et al.Study on the Shaping Process of ZhuQi FuGan Granules[J].Western Journal of Traditional Chinese Medicine,2014,27(02):41-43.
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珠芪复肝颗粒成型工艺研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年02期
页码:
41-43
栏目:
出版日期:
2014-02-15

文章信息/Info

Title:
Study on the Shaping Process of ZhuQi FuGan Granules
文章编号:
1004-6852(2014)02-0041-03
作者:
李彩东1，梁云2，张伟1，吴斌1
1 兰州市第二人民医院肝病研究所，甘肃 兰州 730046； 2 兰州市肺科医院药剂科
Author(s):
LI Caidong1, LIANG Yun2, ZHANG Wei1, WU Bin1
1 Liver Disease Institute of Lanzhou Municipal the Second People′s Hospital, Lanzhou 730046, China; 2 Department of Pharmacy in Lanzhou Municipal Lung Hospital
关键词:
珠芪复肝颗粒; 成型工艺; 正交试验
Keywords:
ZhuQi FuGan Granules;  shaping technology;  orthogonal design
分类号:
R286
文献标志码:
A
摘要:
目的：确定珠芪复肝颗粒的成型(制粒)工艺条件。方法：采用正交试验，以成型率和流动性为指标，以提取物与辅料的比例、乙醇浓度、辅料用量和干燥温度为考察因素，优选成型工艺。结果：最佳成型工艺为辅料以淀粉：微晶纤维素=1∶1配比、提取物与辅料按3∶2的比例混匀，以80%乙醇为润湿剂制软材，干燥温度为60℃，成品颗粒的流动性和溶化性好，临界相对湿度约为67%。结论：该成型工艺可行、稳定合理、重现性较好，可为工业化生产提供理论依据。
Abstract:
Objective: To optimize the shaping technology of ZhuQi FuGan Granules. Methods: By taking the forming rate and mobility as the indexes, the technology was optimized through orthogonal design with the ration of extractive and adjuvant materials, the concentrations of ethanol, the consumption of adjuvant materials and the drying temperature as the factors. Results: The best shaping technology was as follows: adjuvant materials were starch to microcrystalline cellulose in the ratio of 1: 1, extractive and adjuvant materials were mixed together in the ratio of 3:2, 80% ethanol was as the wetting agent, the drying temperature was 60℃, the mobility and melting of the granules were good, critical relative humidity was 67% or so. Conclusion: The shaping technology, feasible, stable, ration and reproducible, could provide theoretical evidence for industrial production.

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备注/Memo

备注/Memo:
收稿日期：2013-05-22作者简介：李彩东(1969—)，女，博士学位，主任药师。研究方向：天然药物化学。
更新日期/Last Update: 2014-02-15