[1]严亚锋,白海侠,周海哲,等.脑清通颗粒对高血压肝热痰瘀证大鼠血浆ET-1和Ang II含量的影响[J].西部中医药,2015,28(09):10-13.
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脑清通颗粒对高血压肝热痰瘀证大鼠血浆ET-1和Ang II含量的影响

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年09期
页码:
10-13
栏目:
出版日期:
2015-09-15

文章信息/Info

文章编号:
1004-6852(2015)09-0010-04
作者:
严亚锋1，白海侠1，周海哲1，李香2
1 陕西中医药大学，陕西 咸阳 712046; 2山东省肥城市老城街道卫生院
关键词:
高血压; 肝热痰瘀证; ET-1; AngⅡ; 脑清通颗粒
分类号:
R331.3
文献标志码:
A
摘要:
目的：观察脑清通颗粒对高血压肝热痰瘀证大鼠血浆中内皮素-1（ET-1）和血管紧张素Ⅱ（AngⅡ）含量的影响，探讨其治疗高血压的作用机制。方法：采用慢性复合电刺激加高脂饮食致大鼠高血压肝热痰瘀证模型，测定大鼠血浆中ET-1和AngⅡ的含量。结果：与治疗前及模型组比较，脑清通颗粒各剂量组治疗第2周血压明显降低（P＜0.01），第3周降压作用最明显；与模型组比较，脑清通颗粒各剂量组均能降低模型大鼠血浆中ET-1和AngⅡ的含量（P＜0.01）。结论：脑清通颗粒可降低高血压肝热痰瘀证模型大鼠血压，其降压机制可能与降低血浆中ET-1和AngⅡ的含量有关。

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备注/Memo

备注/Memo:
*基金项目：陕西省教育厅2013年科学研究项目计划（自然科学专项）（编号2013JK0831）；陕西省教育厅2014年科学研究项目计划（自然科学专项）（编号14JK1195）。作者简介：严亚锋（1976—），男，硕士学位，工程师，讲师。研究方向：老年病的防治及其中药药理学。
更新日期/Last Update: 2015-09-15