生脉膨化胶囊对心气虚小鼠的影响-《西部中医药》

文章信息/Info

Title:: Influences of ShengMai Puffed Capsules on Mice with Heart-Qi Deficiency

Author(s):: WANG Yiping1, YIN Ye2, WANG Shengming2, XIONG Xiong1; 1 Emei Campus,Southwest Jiaotong University, Emei Sichuan 614202, China; 2 School of Bioscience and Engineering, Southwest Jiaotong University

摘要:: 目的：探讨膨化技术对药物剂量及治疗气虚效果的影响。方法：采用传统方法及膨化技术制备生脉胶囊及膨化生脉胶囊；建立小鼠心气虚动物模型，检测小鼠心肌匀浆中超氧化物歧化酶（SOD）、丙二醛（MDA）、乳酸脱氢酶（LDH）、肌酸激酶（CK）含量，研究生脉膨化胶囊对心气虚小鼠的保护作用。结果：生脉膨化胶囊可明显提高心气虚小鼠心肌匀浆中SOD活性，尤以生脉膨化胶囊中剂量组最为显著（P＜0.05）；生脉膨化胶囊可显著降低MDA含量，且中剂量组效果明显优于传统生脉胶囊组（P＜0.05）；生脉膨化胶囊能够显著降低心气虚小鼠心肌匀浆中CK、LDH酶活性（P＜0.05），其降低LDH的效果显著优于传统生脉胶囊组（P＜0.05）。结论：膨化技术能有效提高生脉胶囊对心气虚小鼠的保护作用，降低其起效浓度。

Abstract:: Objective: To explore the influences of puffed technology on drug dosage and effects for treating Qi deficiency. Methods:ShengMai capsules and ShengMai puffed capsules were made by using traditional methods and puffed technology; mice model with heart-Qi dificency was built, SOD, MDA, LDH, CK levels in myocardial homogenate were detected, protection for mice with heart-Qi deficiency of ShengMai puffed capsules were studied. Results: ShengMai puffed capsules can improve the activity of SOD in myocardial homogenate of mice with heart-Qi deficiency, the dosage group of ShengMai puffed capsules was the most significant(P＜0.05); ShengMai puffed capsules can reduce MDA level, the moderate dosage group was superior to the ShengMai puffed capsules group(P＜0.05); ShengMai puffed capsules can reduce activity of CK and LDH in myocardial homogenate of mice with heart-Qi deficiency(P＜0.05), its effect was superior to traditional ShengMai capsules notably(P＜0.05). Conclusion: Puffed technology can promote protection for mice with heart-Qi deficiency of ShengMai puffed capsules effectively and reduce its effective concentration.