[1]陈宝,邢福军△.6种肿瘤标志物联合检测在肺癌诊疗中的价值[J].西部中医药,2017,30(08):158-160.
　CHEN Bao,XING Fujun.The Value of Combined Detection of Six Tumor Markers in the Diagnosis and Treatment of Lung Cancer[J].Western Journal of Traditional Chinese Medicine,2017,30(08):158-160.
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6种肿瘤标志物联合检测在肺癌诊疗中的价值
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年08期
页码:
158-160
栏目:
出版日期:
2017-08-15

文章信息/Info

Title:
The Value of Combined Detection of Six Tumor Markers in the Diagnosis and Treatment of Lung Cancer
文章编号:
1004-6852(2017)08-0158-03
作者:
陈宝1，邢福军2△
1 高台县中医医院，甘肃 高台 734300; 2 甘肃省中医院
Author(s):
CHEN Bao1, XING Fujun2△
1 Gaotai County TCM Hospital, Gaotai 734300, China; 2 Gansu Provincial Hospital of Traditional Chinese Medicine
关键词:
肺癌; 肿瘤标志物; 联合检测
Keywords:
lung cancer;  tumor marker;  combined detection
分类号:
R73-37
文献标志码:
B
摘要:
目的：探讨血清癌胚抗原(CEA)、糖基类抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌相关抗原(SCCA)、胃泌素释放肽前体(ProGRP)肿瘤标志物联合检测在肺癌诊断中的应用价值。方法：以152例肺癌患者、175例肺良性疾病患者和150例健康体检者为观察对象，分别检测血清CEA、CA125、CYFRA21-1、NSE、SCCA和ProGRP水平。结果：肺癌组6种标志物水平显著高于肺良性疾病组和对照组，差异有统计学意义(P＜0.05)。腺癌患者血清CEA、CA125水平明显高于鳞癌、非小细胞肺癌和小细胞肺癌，差异有统计学意义(P＜0.05)。鳞癌CYFRA21-1、SCCA水平较腺癌和小细胞肺癌高，差异有统计学意义(P＜0.05)。ProGRP水平小细胞肺癌组显著高于鳞癌和腺癌组，差异有统计学意义(P＜0.05)。血清肿瘤标志物CEA、CA125、CYFRA21-1、NSE、SCCA和ProGRP单一检测敏感度均不及联合检测，但联合诊断特异性不及CYFRA21-1 和NSE。结论：肿瘤标志物联合检测在肺癌筛查中应用价值较高，但肺癌确诊中联合检测特异性不及某些标志物单一检测。
Abstract:
Objective: To explore the values of combined detection of CEA, CA125, CYFRA21-1, NSE, SCCA and proGRP in the diagnosis of lung cancer. Methods: All 152 patients with lung cancer, 175 patients with benign lung diseases and 150 people undergoing healthy examination were chosen as the objects for observation, to detect the levels of CEA, CA125, CYFRA21-1, NSE, SCCA and ProGRP respectively. Results: The levels of six tumor markers in lung cancer group were higher than these of benign lung diseases group and the control group, and the difference had statistical meaning (P＜0.05). The levels of CEA and CA125 in the patients with glandular cancer were higher than these of the patients with SC, non small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC), and the difference had statistical meaning (P＜0.05). The levels of CYFRA21-1 and SCCA in SC patients were higher than these of the patients with glandular cancer and SCLC, and the difference showed statistical meaning (P＜0.05). The level of ProGRP in SCLC group were higher than these of SC and glandular cancer group, and the difference indicated statistical meaning (P＜0.05). The sensitivity of single tumor marker such as CEA, CA125, CYFRA21-1, NSE, SCCA and ProGRP was not as good as combined detection, but the specificity of combined detection was not as good as CYFRA21-1 and NSE. Conclusion: The values of combined detection of tumor marker are higher in screening lung cancer, while the specificity of combined detection is not as good as single detection of some marker in the diagnosis of lung cancer.

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备注/Memo

备注/Memo:
收稿日期：2017-02-20 作者简介：陈宝(1978—)，男，主治医师。研究方向：胃肠、胆道等疾病的微创治疗。 △通讯作者：邢福军(1967—)，男，主任检验师。研究方向：医学检验。
更新日期/Last Update: 2017-08-15