[1]刘莹露,吴薇,徐天舒△.胆宁片对胆色素结石型豚鼠胆汁CRP、血清PGE2及血清胰岛素敏感性的影响[J].西部中医药,2017,30(11):18-21.
　LIU Yinglu,WU Wei,XU Tianshu.The Effects of DanNing Tablets on Bile CRP, Serum PGE2 and Serum Insulin Sentivity of Bile Pigment Calculus Type Guinea Pigs[J].Western Journal of Traditional Chinese Medicine,2017,30(11):18-21.
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胆宁片对胆色素结石型豚鼠胆汁CRP、血清PGE2及血清胰岛素敏感性的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年11期
页码:
18-21
栏目:
出版日期:
2017-11-15

文章信息/Info

Title:
The Effects of DanNing Tablets on Bile CRP, Serum PGE2 and Serum Insulin Sentivity of Bile Pigment Calculus Type Guinea Pigs
文章编号:
1004-6852(2017)11-0018-04
作者:
刘莹露，吴薇，徐天舒△
南京大学医学院附属鼓楼医院中医科，江苏 南京 210008
Author(s):
LIU Yinglu, WU Wei, XU Tianshu△
TCM Department, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, China
关键词:
胆色素型结石; C反应蛋白; 前列腺素E2; 胰岛素敏感性指数; 胆宁片
Keywords:
bile pigment calculus;  CRP;  PGE2;  ISI;  DanNing tablets
分类号:
R737
摘要:
目的：探讨胆宁片对胆色素结石型豚鼠胆汁C反应蛋白(CRP)、血清前列腺素E2(PGE2)及血清胰岛素敏感性指数(ISI)的影响。方法：构建胆色素结石型豚鼠模型，给予胆宁片小、中、大剂量治疗，治疗后用ELISA法测定胆汁中CRP、血清中PGE2及血清胰岛素的含量，血糖仪测得血糖，计算胰岛素敏感性指数。结果：胆宁片各剂量组豚鼠胆汁CRP及血清PGE2含量较模型组明显减少，差异有统计学意义(P＜0.05)，且胆宁片各剂量组间比较差异有统计学意义(P＜0.05)；模型组豚鼠血清胰岛素敏感性指数(ISI)较空白组及胆宁片各剂量组下降，差异有统计学意义(P＜0.05)；通过双变量相关性分析，豚鼠血清PGE2与胰岛素敏感性指数(ISI)呈负相关。结论：胆宁片能够影响胆色素结石型豚鼠炎性物质及胰岛素敏感性，其机制可能与改善炎症反应及胰岛素敏感性有关。
Abstract:
Objective: To discuss the influence of DanNing tablets on bile CRP, serum prostaglandin E2(PGE2) and serum insulin sensitivity index(ISI) of bile pigment calculus type guinea pig. Methods: Bile pigment calculus type guinea pigs were established, and treated with DanNing tablets in low, moderate and high dose, after treating, the contents of CRP, PGE2 in the serum and serum insulin in the bile were detected by ELISA method, and blood sugar was detected by glucose meter to calculate ISI. Results: Different doses groups of DanNing tablets were less than the model group in the contents of CRP and PGE2 in the serum, and the difference had statistical meaning(P＜0.05), and the difference had statistical meaning in the comparisons among different doses groups of DanNing tablets (P＜0.05); ISI of the model group decreased compared with the blank group and different doses groups of DanNing tablets, and the difference had statistical meaning(P＜0.05); by bivariate correlation analysis, there was negative correlation between serum PGE2 and ISI. Conclusion: DanNing tablets could affect inflammatory substance and the sensitivity of insulin of bile pigment calculus type guinea pig, and its mechanism might be related to improve inflammatory reaction and insulin sensitivity.

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备注/Memo

备注/Memo:
收稿日期：2017-02-28 *基金项目：中国中西医结合学会-和黄科研基金项目(编号2012004)。 作者简介：刘莹露(1983—)，女，硕士学位，主治医师。研究方向：内分泌代谢疾病的诊治。 △通讯作者：徐天舒(1964—)，女，博士学位，主任医师。研究方向：老年病的诊治。
更新日期/Last Update: 2017-11-15