[1]聂晶,郑超,李馨△.参麦注射液联合依那普利治疗老年高血压伴冠心病不稳定型心绞痛疗效观察[J].西部中医药,2017,30(11):93-97.
　NIE Jing,ZHENG Chao,LI Xin.Study on Clinical Effects of ShenMai Injection Combined with Enalapril in the Treatment of Senile Hypertension Complicated with CHD Unstable Angina Pectoris[J].Western Journal of Traditional Chinese Medicine,2017,30(11):93-97.
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参麦注射液联合依那普利治疗老年高血压伴冠心病不稳定型心绞痛疗效观察()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年11期
页码:
93-97
栏目:
出版日期:
2017-11-15

文章信息/Info

Title:
Study on Clinical Effects of ShenMai Injection Combined with Enalapril in the Treatment of Senile Hypertension Complicated with CHD Unstable Angina Pectoris
文章编号:
1004-6852(2017)11-0093-05
作者:
聂晶，郑超，李馨△
重庆市红十字会医院/江北区人民医院，重庆 400020
Author(s):
NIE Jing, ZHENG Chao, LI Xin△
Chongqing Municipality Red Cross Hospital/Jiangbei District People′s Hospital, Chongqing 400020, China
关键词:
高血压; 不稳定型心绞痛; 冠心病; 老年; 参麦注射液; 依那普利
Keywords:
hypertension;  unstable angina pectoris;  coronary heart disease;  senile;  ShenMai injection;  enalapril
分类号:
R541.4
摘要:
目的：观察参麦注射液联合依那普利治疗老年高血压伴冠心病不稳定型心绞痛的临床疗效及安全性。方法：将冠心病不稳定型心绞痛合并高血压老年患者86例按随机数字表法分为对照组43例予常规抗心绞痛及降压治疗，研究组43例在对照组治疗的基础上予参麦注射液联合依那普利治疗，观察并记录2组患者中医证候评分、心绞痛各参数、脂肪细胞因子及相应指标，同时对比不良反应发生情况。结果：与治疗前比较，2组治疗后中医证候评分及心绞痛各项参数均降低，血清脂联素(APN)水平升高，血清瘦素(Leptin)及内脂素(Visfatin)水平降低，血清同型半胱氛酸(Hcy)、一氧化碳(NO)、高敏C反应蛋白(Hs-CRP)及肿瘤坏死因子α(TNF-α)水平降低，差异具有统计学意义(P＜0.05)；与对照组比较，研究组治疗后中医证候评分及心绞痛各项参数较低，APN水平较高，Leptin及Visfatin水平较低，血清Hcy、NO、Hs-CRP及TNF-α水平较低，差异具有统计学意义(P＜0.05)；2组患者无病例脱落现象，2组间不良反应发生率比较差异无统计学意义(P＞0.05)。结论：参麦注射液联合依那普利治疗老年高血压伴冠心病不稳定型心绞痛疗效优于常规西药治疗，且不良反应低。
Abstract:
Objective: To investigate clinical effects and the safety of ShenMai injection combined with enalapril in the treatment of senile hypertension complicated with coronary heart disease (CHD) unstable angina pectoris. Methods: All 86 senile hypertension patients complicated with CHD unstable angina pectoris were randomly divided into two groups: 43 cases in the control group who were treated with regular anti angina pectoris and antihypertension therapy, and 43 cases in the experiment group who were treated with ShenMai injection and enalapril on the base of the therapy that the control group accepted, TCM symptoms scores, various parameters of angina pectoris, adipocyte factors and the corresponding indexes of both groups were observed and recorded, at the same time, the conditions of adverse reaction were compared. Results: Compared with before treating, TCM symptoms scores decreased, various parameters of angina pectoris decreased, APN level increased, Leptin and Visfation levels decreased, the levels of serum Hcy, NO, Hs-CRP and TNF-α lowered in both groups after treating, and the difference had statistical meaning (P＜0.05); compared with the control group, TCM symptoms scores lowered, various parameters of angina pectoris decreased, APN level increased, Lepin and Visfatin levels decreased, the levels of serum Hcy, NO, Hs-CRP and TNF-α lowered in the experiment group after treating, and the difference showed statistical meaning (P＜0.05); No case dropped out in both groups, and the difference had no statistical meaning in the comparisons of the incidence of adverse reaction between both groups (P＞0.05). Conclusion: Curative effects of ShenMai injection combined with enalapril are superior to these of conventional western medicine in the treatment of senile hypertension complicated with CHD unstable angina pectoris with low adverse reaction.

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备注/Memo

备注/Memo:
收稿日期：2016-10-16 作者简介：聂晶(1979—)，女，主治医师。研究方向：心血管疾病的诊治。 △通讯作者：李馨(1980—)，女，主治医师。研究方向：心血管疾病的诊治。
更新日期/Last Update: 2017-11-15