[1]任芳,王有奎,徐厚谦,等.尿nephrin与肌酐比率和RBP-4在2型糖尿病肾病诊断中的意义[J].西部中医药,2017,30(11):126-128.
　REN Fang,WANG Youkui,XU Houqian,et al.The Signficance of Urinary Nephrin-Creatinine Ratio and RBP-4 in the Diagnosis of Type 2 Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2017,30(11):126-128.
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尿nephrin与肌酐比率和RBP-4在2型糖尿病肾病诊断中的意义()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年11期
页码:
126-128
栏目:
出版日期:
2017-11-15

文章信息/Info

Title:
The Signficance of Urinary Nephrin-Creatinine Ratio and RBP-4 in the Diagnosis of Type 2 Diabetic Nephropathy
文章编号:
1004-6852(2017)11-0126-03
作者:
任芳1，王有奎1，徐厚谦2，唐霞1，段雪萍1，胡菊梅1，罗英剑3，常运朝3，车团结4△
1 金昌市第一人民医院，甘肃 金昌 737100； 2 甘肃中医药大学； 3 甘肃省生物芯片工程实验室； 4 甘肃省功能基因组与分子诊断重点实验室
Author(s):
REN Fang1, WANG Youkui1, XU Houqian2, TANG Xia1, DUAN Xueping1, HU Jumei1, LUO Yingjian3, CHANG Yunchao3, CHE Tuanjie4△
1 Jinchang Municipality the First People′s Hospital, Jinchang 737100, China; 2 Gansu University of Traditional Chinese Medicine; 3 Gansu Provincial Engineering Lab of Biochip; 4 Gansu Provincial Key Lab of Function Genome and Molecular Detection
关键词:
糖尿病肾病; nephrin; 肌酐比率; 视黄醇结合蛋白4; 诊断
Keywords:
diabetic nephropathy;  nephrin;  UNCR;  RBP-4;  diagnosis
分类号:
R587
摘要:
目的：探讨尿nephrin与肌酐比率(UNCR)和视黄醇结合蛋白4(RBP-4)在2型糖尿病肾病诊断中的意义。方法：选取2型糖尿病患者110例，正常健康对照组40例。采用定量酶联免疫吸附法(ELISA)测定2组患者尿白蛋白、肌酐、nephrin和RBP-4的含量，依据尿白蛋白与肌酐比率(UACR)将糖尿病患者分为正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组，进行UNCR与RBP-4相关性分析。结果：正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组UNCR比较差异具有统计学意义(P＜0.05)；正常白蛋白尿组UNCR阳性率为51.7%，而微量白蛋白尿组和大量白蛋白尿组UNCR阳性率均大于95%，UNCR与RBP-4呈正相关。正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组RBP-4含量比较差异具有统计学意义(P＜0.05)。结论：UNCR和RBP-4在糖尿病早期诊断和预测糖尿病肾病病情进展中有重要的指示作用。
Abstract:
Objective: To investigate the value of urinary nephrin-creatinine ratio (UNCR) and RBP-4 in the diagnosis of type 2 diabetic nephropathy. Methods: Altogether 110 patients with type 2 diabetes mellitus (DM group) and 40 normal healthy people as the control group were chosen. The contents of urinary albumin, creatinine, nephrin and RBP-4 of the patients in both groups were detected by using ELISA assay, DM group was divided into urinary albumin negative group (DM group), microalbuminuria group and macroalbuminuria group according to UNCR, and the correlation between UNCR and RBP-4 was analyzed. Results: The difference had statistical meaning in the comparisons among DM group, microalbuminuria group and macroalbuminuria group (P＜0.05); UNCR positive rate of DM group was 51.7%, while the rates of microalbuminuria group and macroalbuminuria group were all greater than 95%, which showed that UNCR was positively correlated to RBP-4. The difference had statistical meaning in the comparisons of RBP-4 contents among DM group, microalbuminuria group and macroalbuminuria group (P＜0.05). Conclusion: UNCR and RBP-4 own important indicative function in early diagnosis of DM and predicting DM disease preogression.

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备注/Memo

备注/Memo:
收稿日期：2017-02-27 *基金项目：兰州市科学计划项目(编号2014-rc-61)；金昌市2014年“镍都百名青年英才开发计划”。 作者简介：任芳(1982—)，女，硕士学位，主治医师。研究方向：内分泌及代谢性疾病的诊治。 △通讯作者：车团结(1970—)，男，博士学位，研究员。研究方向：分子生物学。
更新日期/Last Update: 2017-11-15