[1]张卉.正本清源汤联合米非司酮治疗围绝经期功能性子宫出血45例[J].西部中医药,2018,31(04):90-92.
　ZHANG Hui.ZhengBen QingYuan Decoction Combined with Mifepristone in Treating 45 Patients with Dysfunctional Uterine Bleeding during Peri-menopausal Period[J].Western Journal of Traditional Chinese Medicine,2018,31(04):90-92.
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正本清源汤联合米非司酮治疗围绝经期功能性子宫出血45例()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年04期
页码:
90-92
栏目:
出版日期:
2018-04-15

文章信息/Info

Title:
ZhengBen QingYuan Decoction Combined with Mifepristone in Treating 45 Patients with Dysfunctional Uterine Bleeding during Peri-menopausal Period
文章编号:
1004-6852(2018)04-0090-03
作者:
张卉
平邑县人民医院，山东 平邑 273300
Author(s):
ZHANG Hui
Pingyi County People′s Hospital, Pingyi 273300, China
关键词:
功能性子宫出血; 正本清源汤; 子宫内膜; 米非司酮
Keywords:
dysfunctional uterine bleeding;  ZhengBen QingYuan decoction;  endometrium;  mifepristone
分类号:
R271.1
文献标志码:
B
摘要:
目的：观察正本清源汤联合米非司酮治疗围绝经期功能性子宫出血的临床疗效及其对子宫内膜厚度的影响。方法：将90例围绝经期功能性子宫出血患者随机分为观察组和对照组，每组45例。观察组于刮宫术后第5天给予正本清源汤联合米非司酮治疗，对照组于刮宫术后第5天给予米非司酮治疗，2组均治疗3个月经周期，比较2组控制出血时间、完全止血时间、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)以及子宫内膜厚度。结果：控制出血时间、完全止血时间观察组短于对照组，2组比较差异有统计学意义(P＜0.05)。FSH、LH以及E2水平治疗后均显著低于治疗前，治疗前后2组组内比较差异有统计学意义；治疗后E2水平2组组间比较差异有统计学意义(P＜0.05)。子宫内膜厚度治疗后2组均显著小于治疗前，差异有统计学意义(P＜0.05)，治疗后2组间比较差异有统计学意义(P＜0.05)。结论：正本清源汤联合米非司酮治疗围绝经期功能性子宫出血疗效显著，能有效止血、改善患者的激素水平，进而减少子宫内膜的厚度。
Abstract:
Objective: To survey clinical effects of ZhengBen QingYuan decoction combined with mifepristone in treating dysfunctional uterine bleeding during peri-menopausal period and its effects on endometrial thickness. Methods: Ninety patients were randomized into the observation group and the control group, 45 cases each group. The patients in the observation group took ZhengBen QingYuan decoction and mifepristone at the fifth day after uterine curettage, and the ones in the control group were treated by mifepristone at the fifth day after uterine curettage, both groups were treated for three menstrual cycles, endometrial thickness, the levels of estradiol (E2), luteinizing hormone (LH) and follicule-stimulating hormone (FSH), complete hemostasis time and the time of controlling hemorrhage were compared between both groups. Results: The observation group was shorter than the control group in complete hemostasis time and the time of controlling hemorrhage, and the difference had statistical meaning (P＜0.05). The levels of FSH, LH, E2after treating were lower than these before treating notably, and the difference showed statistical meaning within two groups before and after treating; the comparisons of the levels of E2after treating between both groups had statistical meaning (P＜0.05). Endometrial thickness after treating in both groups was smaller than the thickness before treating, and the difference was statistically significant (P＜0.05), and the difference showed statistical meaning in the comparisons between both groups after treating (P＜0.05). Conclusion: ZhengBen QingYuan decoction combined with mifepristone is effective in treating dysfunctional uterine bleeding during peri-menopausal period, which could effectively stop the bleeding, improve hormone levels of the patients, therefore to reduce endometrial thickness.

相似文献/References:

[1]张春青.健脾祛瘀固冲法治疗围绝经期崩漏39例[J].西部中医药,2013,26(03):86.
　ZHANG Chunqing.Treatment for 39 Cases of Metrorrhagia and Metrostaxis during Peri-menopausal Periodwith the Method of Invigorating Spleen, Eliminating Stasis and Strengthening Thoroughfare Vessels[J].Western Journal of Traditional Chinese Medicine,2013,26(04):86.

备注/Memo

备注/Memo:
收稿日期：2016-11-01 *基金项目：山东中医药科技发展计划项目(编号SDZ-20130129)。 作者简介：张卉(1970—)，女，副主任医师。研究方向：妇科疾病的诊治。
更新日期/Last Update: 2018-04-15