麝香保心渗透泵控释片体外释放的影响因素研究-《西部中医药》

文章信息/Info

Title:: Research on the Factors Affecting SheXiang BaoXin Osmotic Pump Controlled Release Tablets Release in Vitro

Author(s):: HU Huanfu; Yueyang Municipality Key Lab of Geriatric Health Care of Yueyang Vocational Technical College, Yueyang 414000, China

Keywords:: osmotic pump controlled release tablets; drug-release in vitro; the influencing factors

摘要:: 目的：制备麝香保心渗透泵控释片，考察该制剂的释药影响因素及释药机理。方法：通过考察渗透泵控释片在不同条件的释放情况，研究影响该制剂的释药因素。结果：麝香保心渗透泵控释片以膜内外的渗透压差为主要释药动力，体外释药符合零级释放规律，释药速率受衣膜增重、片芯硬度、衣膜中致孔剂含量影响较大，与渗透压活性物质的种类、溶出方法、介质pH值、转速无关。结论：麝香保心渗透泵控释片释药稳定，零级释药明显，具备优良控释制剂的特征。

Abstract:: Objective: To survey the factors affecting SheXiang BaoXin osmotic pump controlled release tablets release in vitro and drug-release mechanism after preparing the preparation. Methods: By investigating the releasing conditions of osmotic pump controlled release tablets under different conditions, the drug-release factors affecting the preparations were studied. Results: by taking osmotic pressure difference inside and outside the membrane as main drug-release power, drug-release in vitro of SheXiang BaoXin osmotic pump controlled release tablets conformed to zero level release rule, drug-release speed was affected by film coating weight gain, the hardness of tablets core, the contents of pore-forming agent in the film coating, was foreign to the sorts of osmotic active substance, dissolution method, pH value of the medium and speed. Conclusion: SheXiang BaoXin osmotic pump controlled release tablets possess the characteristics of excellent controlled release preparation, which shows drug release stability and notable zero level drug release.