[1]朱晓铭,李亮,唐晓勇,等.茴香枳术汤对实验性大鼠粘连性肠梗阻血浆IL-2、TNF-α的影响[J].西部中医药,2018,31(07):27-29.
　ZHU Xiaoming,LI Liang,TANG Xiaoyong,et al.Effects of HuiXiang ZhiZhu Decoction on the Expressions of IL-2 and TNF-α in the Serum of Experimental Rats with Adhesive Ileus[J].Western Journal of Traditional Chinese Medicine,2018,31(07):27-29.
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茴香枳术汤对实验性大鼠粘连性肠梗阻血浆IL-2、TNF-α的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年07期
页码:
27-29
栏目:
出版日期:
2018-07-15

文章信息/Info

Title:
Effects of HuiXiang ZhiZhu Decoction on the Expressions of IL-2 and TNF-α in the Serum of Experimental Rats with Adhesive Ileus
文章编号:
1004-6852(2018)07-0027-03
作者:
朱晓铭，李亮，唐晓勇，陈玉庆，刘强光，郑君，乔登嫣，骆元斌，刘迎萍，屈红
甘肃省中医院，甘肃 兰州 730050
Author(s):
ZHU Xiaoming, LI Liang, TANG Xiaoyong, CHEN Yuqing, LIU Qiangguang, ZHENG Jun, QIAO Dengyan, LUO Yuanbin, LIU Yingping, QU Hong
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
粘连性肠梗阻; 白细胞介素; 肿瘤坏死因子α; 茴香枳术汤
Keywords:
adhesive ileus;  IL-2;  TNF-α;  HuiXiang ZhiZhu decoction
分类号:
R574.2
文献标志码:
A
摘要:
目的：探讨茴香枳术汤对粘连性肠梗阻大鼠血浆白细胞介素2(IL-2)、肿瘤坏死因子α(TNF-α)水平的影响。方法：将Wistar大鼠72只随机分为正常组、假手术组、模型组及茴香枳术汤低、中、高剂量组，每组12只。给予相应药物治疗3天，末次给药后12小时后股动脉取血，酶联免疫吸附法(ELISA)检测血浆IL-2、TNF-α。结果：与正常组比较，模型组血浆IL-2含量、TNF-α水平显著增加(P＜0.01)；与模型组比较，茴香枳术汤低、中、高剂量组血浆IL-2含量、TNF-α水平显著下降(P＜0.01)，且高剂量组效果优于中、低剂量组。结论：茴香枳术汤治疗粘连性肠梗阻的作用机制与保护肠道微生态功能有关。
Abstract:
Objective: To discuss the effects of HuiXiang ZhiZhu decoction on the levels of IL-2 and TNF-α in the serum of the rats with adhesive ileus. Methods: All 72 rats were randomized into the normal group, sham operation group, the model group, low, moderate and high doses groups of HuiXiang ZhiZhu decoction, 12 rats each group. They were treated by the corresponding medicine for three days, the blood was drawn from femoral in 12 hours since the last medication, the levels of IL-2 and TNF-α in the serum were measured by ELISA method. Results: Compared with the normal group, the contents of IL-2 and the level of TNF-α in the model group increased notably (P＜0.01); compared with the model group, the contents of IL-2 and the level of TNF-α in the serum of low, moderate and high dose groups of HuiXiang ZhiZhu decoction decreased remarkably (P＜0.01), and high dose group was superior to moderate and low dose groups in the effects. Conclusion: The mechanism of HuiXiang ZhiZhu decoction treating adhesive ileus is related to protecting intestinal microecology.

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备注/Memo

备注/Memo:
收稿日期：2017-12-06 *基金项目：甘肃省中医药管理局科研课题(编号GZK-2016-66)。 作者简介：朱晓铭(1964—)，男，副主任医师。研究方向：肠道肿瘤的防治。
更新日期/Last Update: 2018-07-15