[1]樊晓明.真武汤治疗脾肾阳虚型糖尿病肾病70例[J].西部中医药,2018,31(10):56-58.
　FAN Xiaoming.ZhenWu Decoction in Treating 70 Cases of Diabetic Nephropathy of Spleen-kidney Yang Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2018,31(10):56-58.
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真武汤治疗脾肾阳虚型糖尿病肾病70例()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年10期
页码:
56-58
栏目:
出版日期:
2018-10-15

文章信息/Info

Title:
ZhenWu Decoction in Treating 70 Cases of Diabetic Nephropathy of Spleen-kidney Yang Deficiency Pattern
文章编号:
1004-6852(2018)10-0056-03
作者:
樊晓明
定西市中医医院，甘肃 定西 743000
Author(s):
FAN Xiaoming
Dingxi Municipality TCM Hospital, Dingxi 743000, China
关键词:
糖尿病肾病; 脾肾阳虚型; 真武汤; 尿蛋白
Keywords:
diabetic nephropathy;  spleen-kidney Yang deficiency;  ZhenWu decoction;  urine protein
分类号:
R587.2
文献标志码:
B
摘要:
目的：观察真武汤治疗脾肾阳虚型糖尿病肾病(DN)的临床疗效。方法：将140例患者随机分为对照组和观察组，每组各70例。2组均给予西医常规治疗，观察组在此基础上同时服用真武汤，1剂/d，水煎分服。2组均连续治疗8周。比较2组治疗前后空腹血糖(FPG)、24小时尿蛋白定量、尿N-乙酰-β-D-葡萄糖苷酶(NAG)、尿α1-微球蛋白(α1-MG)、尿素氮(BUN)、血清肌酐(Scr)、肌酐清除率(Ccr)和血清光抑素C(cystatin C)的变化情况及临床疗效。结果：FPG、24小时尿蛋白定量、NAG、α1-MG、BUN、Scr、Ccr、cystatin C等指标治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。总有效率观察组为88.57%，对照组为67.14%，2组比较差异有统计学意义(P＜0.05)。结论：真武汤治疗脾肾阳虚型DN临床疗效显著，可降低血糖和尿蛋白含量，改善肾功能。
Abstract:
Objective: To observe curative effects of ZhenWu decoction in treating diabetic nephropathy (DN) of spleen-kidney Yang deficiency pattern. Methods: All 140 patients were randomly separated into the control group and the observation group, 70 cases each group. Both groups received conventional therapy of Western medicine, the observation group took ZhenWu decoction, one dose each day, water decocted. Both groups were treated for eight consecutive weeks. Clinical effects, the changes of serum cystatin C, creatinine clearance rate (Ccr), serum creatinine(Scr), blood usea nitrogen(BUN), urinary α1-microglobulin (α1-MG), urinary N-acetyl-β-D-glucosidase (NAG), 24-hour urinary protein quantification and fasting plasma glucose(FPG) of the patients were compared before and after treating between both groups. Results: The difference was statistically significant in the comparisons of FPG, 24-hour urinary protein quantification, NAG, α1-MG, BUN, Scr, Ccr, Cys C and others within two groups before and after treating (P＜0.05); the difference was statistically significant in the comparisons between both groups after treating(P＜0.05). Total effective rate of the observation group was 88.57%, higher than 67.14% of the control group, and the difference was statistically significant (P＜0.05). Conclusion: ZhenWu decoction is effective in treating DN of spleen-kidney Yang deficiency pattern, it could lower blood glucose, improve renal function and decrease the contents of urine protein.

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备注/Memo

备注/Memo:
收稿日期：2018-03-20 作者简介：樊晓明(1978—)，男，副主任药师。研究方向：中药学。
更新日期/Last Update: 2018-08-15