[1]杨薇薇.SASP加中药保留灌肠治疗溃疡性结肠炎64例[J].西部中医药,2019,32(01):102-105.
　YANG Weiwei.Treating 64 Cases of Ulcerative Colitis by SASP and Herbal Retention Enema[J].Western Journal of Traditional Chinese Medicine,2019,32(01):102-105.
点击复制

SASP加中药保留灌肠治疗溃疡性结肠炎64例
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年01期
页码:
102-105
栏目:
出版日期:
2019-01-15

文章信息/Info

Title:
Treating 64 Cases of Ulcerative Colitis by SASP and Herbal Retention Enema
文章编号:
1004-6852(2019)01-0102-04
作者:
杨薇薇
中国人民解放军第180医院药学科，福建 泉州362000
Author(s):
YANG Weiwei
Department of Pharmacy, Hospital 180 of PLA, Quanzhou 362000, China
关键词:
结肠炎; 溃疡性; 柳氮磺胺吡啶; 中药; 保留灌肠; 炎症因子
Keywords:
colitis;  ulcerative;  SASP;  herbs;  retention enema;  inflammatory factor
分类号:
R574
文献标志码:
B
摘要:
目的:观察柳氮磺胺吡啶(SASP)加中药保留灌肠治疗溃疡性结肠炎的临床疗效。方法：将溃疡性结肠炎患者128例随机分为对照组和观察组各64例。对照组口服SASP肠溶片，观察组同时采用中药汤剂保留灌肠治疗，1次/d。20 天为1个疗程，疗程间间隔1周，连续治疗3个疗程。对比2组临床疗效及治疗前后Southerland DAI评分、内镜Baron评分和血清肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平的变化情况。结果：Southerland DAI评分、内镜Baron评分、每日大便次数治疗前后2组组内及组间比较，差异有统计学意义(P＜0.05)。总有效率对照组为78.1%，观察组为93.8%，2组比较差异有统计学意义(P＜0.05)。血清TNF-α和IL-6水平治疗前后2组组内及组间比较差异有统计学意义(P＜0.05)。结论：SASP加中药保留灌肠治疗溃疡性结肠炎疗效确切，并能减轻患者机体炎症反应程度。
Abstract:
Objective: To observe clinical effects of salazosulfapyridine (SASP) and herbal retention enema in treating ulcerative colitis (UC). Methods: All 128 UC patients were randomized into the control group and the observation group, 64 cases each group. The control group took SASP enteric-coated tablets, and the observation group accepted herbal retention enema simultaneously, once each day. All 20 days were one course, the interval was one week, both groups were treated for three courses consecutively. The levels of IL-6 and TNF-α, endoscopic Baron scores, Southerland DAI scores and clinical effects of both groups were compared before and after treating. Results: The differences had statistical meaning in the comparisons of Southerland DAI scores, endoscopic Baron scores and the times of motions within two groups before and after treating, and between both groups (P＜0.05). Total effective rate of the control group was 78.1%, lower than 93.8% of the observation group, and the difference showed statistical meaning (P＜0.05). The difference showed statistical meaning in the comparisons of the levels of TNF-α and IL-6 within two groups before and after treating, and between both groups (P＜0.05). Conclusion: SASP and herbal retention enema could obtain definite effects in treating UC, and it could relieve inflammatory reaction of the patients.

相似文献/References:

[1]黄文静.猴耳环消炎颗粒治疗婴幼儿过敏性结肠炎40例[J].西部中医药,2019,32(06):80.
　HUANG Wenjing.Treating 40 Cases of Infantile Allergic Colitis with HouErHuan XiaoYan Granules[J].Western Journal of Traditional Chinese Medicine,2019,32(01):80.
[2]常文丽,李晓华,邵秋香,等.中药口服液联合中药直肠滴入对溃疡性直肠炎临床疗效和炎症因子及凝血指标的影响[J].西部中医药,2023,36(08):119.[doi:10.12174/j.issn.2096-9600.2023.08.29]
　CHANG Wenli,LI Xiaohua,SHAO Qiuxiang,et al.Clinical Effects of Oral Liquid of Chinese Medicine and Rectal Dripping of Chinese Medicine in the Treatment of Ulcerative Rectitis and Its Impacts on Inflammatory Factors and Coagulation Indicators[J].Western Journal of Traditional Chinese Medicine,2023,36(01):119.[doi:10.12174/j.issn.2096-9600.2023.08.29]
[3]王春虹,姚丽丽,王婷婷,等.清脾泻热汤联合短波紫外线对小儿溃疡性口腔炎临床疗效的影响[J].西部中医药,2024,37(06):158.[doi:10.12174/j.issn.2096-9600.2024.06.37]
　WANG Chunhong,YAO Lili,WANG Tingting,et al.The Impacts of Spleen-clearing Heat-purging Decoction Joined with Short-wave Ultraviolet C on the Clinical Efficacy of Pediatric Ulcerative Stomatitis[J].Western Journal of Traditional Chinese Medicine,2024,37(01):158.[doi:10.12174/j.issn.2096-9600.2024.06.37]
[4]武颜荣,阚存玲.固本益肠片联合美沙拉嗪片治疗中重度溃疡性结肠炎19例*[J].西部中医药,2013,26(01):79.
　WU Yanrong,KAN Cunling.Clinical Observation on GuBen Y iChang Tablets and Mesalazine Tablets in Treating Moderate and Severe Ulcerative Colitis：A Report of 19 Cases[J].Western Journal of Traditional Chinese Medicine,2013,26(01):79.
[5]冉玉.消溃愈疡汤联合艾迪莎治疗溃疡性结肠炎50例[J].西部中医药,2013,26(03):101.
　RAN Yu.XiaoKui YuYangTang and Etiasa in Treating 50 Cases of Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2013,26(01):101.
[6]景姗,王新月,杨雪,等.溃疡性结肠炎大鼠肺、肠组织中TGF-β1、SP-A表达的改变及中药的干预作用*[J].西部中医药,2014,27(03):10.
　JING Shan,WANG Xinyue,YANG Xue,et al.The Expressions of TGF-β1 and SP-A in the Lung and the Intestines of Rats with Ulcerative Colitis and TCM Intervention on the Changes[J].Western Journal of Traditional Chinese Medicine,2014,27(01):10.
[7]张艳.初发与复发溃疡性结肠炎院外治疗依从性的调查与分析[J].西部中医药,2017,30(02):58.
　ZHANG Yan.Investigation and Analysis of Extramural Hospital Treatment Compliance of Incipient and Relapse Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2017,30(01):58.
[8]丁永福.健脾清肠汤治疗脾虚湿热型溃疡性结肠炎40例[J].西部中医药,2018,31(02):88.
　DING Yongfu.JianPi QingChang Decoction in Treating 40 Cases of Ulcerative Colitis of Spleen-deficiency Damp-heat Pattern[J].Western Journal of Traditional Chinese Medicine,2018,31(01):88.
[9]何永成,马国杰.中医分期治疗溃疡性结肠炎43例[J].西部中医药,2018,31(08):81.
　HE Yongcheng,MA Guojie.TCM Phased Therapy in Treating 43 Cases of Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2018,31(01):81.
[10]陈步强,常忠生,指导：陆金根.陆金根教授治疗轻中度溃疡性结肠炎学术思想探析[J].西部中医药,2020,33(02):47.[doi:10.12174/j.issn.1004-6852.2020.02.13]
　CHEN Buqiang,CHANG ZhongshengDirector: LU Jingen.Professor Lu Jingen′s Academic Thinking of Treating Mild - to - moderate Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2020,33(01):47.[doi:10.12174/j.issn.1004-6852.2020.02.13]
[11]沈照峰,朱磊,刘亚军,等.基于德尔菲法的溃疡性结肠炎患者相关危险因素调查分析[J].西部中医药,2020,33(04):82.[doi:10.12174/j.issn.1004-6852.2020.04.25]
　SHEN Zhaofeng,ZHU Lei,LIU Yajun,et al.An Investigation into the Related Risk Factors of UC Patients Based on Delphi Method[J].Western Journal of Traditional Chinese Medicine,2020,33(01):82.[doi:10.12174/j.issn.1004-6852.2020.04.25]
[12]杨洁,施丽婕.化瘀通阳方对溃疡性结肠炎大鼠IL-23/JAK-STAT信号通路的影响[J].西部中医药,2021,34(04):17.[doi:10.12174/j.issn.2096-9600.2021.04.05]
　YANG Jie,SHI Lijie.Effects of Stasis-resolving Yang-activating Prescription on IL-23/JAK-STAT Signaling Pathway in UC Rats[J].Western Journal of Traditional Chinese Medicine,2021,34(01):17.[doi:10.12174/j.issn.2096-9600.2021.04.05]
[13]杨武,张涛,廖美华,等.基于古代文献挖掘探析从肺肾论治溃疡性结肠炎[J].西部中医药,2023,36(10):67.[doi:10.12174/j.issn.2096-9600.2023.10.15]
　YANG Wu,ZHANG Tao,LIAO Meihua,et al.Treatment of Ulcerative Colitis from Lung and Kidney Based on Ancient Literature Mining[J].Western Journal of Traditional Chinese Medicine,2023,36(01):67.[doi:10.12174/j.issn.2096-9600.2023.10.15]

备注/Memo

备注/Memo:
收稿日期：2018-06-27 作者简介：杨薇薇(1980—)，女，主治医师。研究方向：中药学。
更新日期/Last Update: 2019-01-15