芫苓消水散联合IL-2腹腔灌注治疗癌性腹水60例-《西部中医药》

文章信息/Info

Title:: YuanLing XiaoShui Powder and Intraperitoneal Perfusion of IL-2 in Treating 60 Cases of Malignant Ascites

Author(s):: LI Xueni, JIANG Chunzhuang, LIU Yanxia; Department of Oncology, Weihai Municipality TCM Hospital, Weihai 264200, China

Keywords:: malignant ascites; YuanLing XiaoShui powder; IL-2; intraperitoneal perfusion

摘要:: 目的：观察芫苓消水散联合IL-2腹腔灌注治疗癌性腹水的临床疗效。方法：将120例癌性腹水患者随机分为对照组和观察组各60例，对照组采用IL-2腹腔灌注治疗，观察组采用IL-2腹腔灌注联合芫苓消水散膏药外敷治疗，治疗2周后比较2组临床疗效、中医证候评分、腹围、腹水深度、24小时尿量、生活质量和毒副反应发生情况。结果：总有效率观察组为85.0%，对照组为65.0%，2组比较差异有统计学意义(P＜0.05)。腹围、腹水深度、24小时尿量、KPS评分、中医证候评分治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后2组组间比较差异也有统计学意义(P＜0.05)。观察组除贫血、恶心呕吐外，其余毒副反应发生率均低于对照组，差异有统计学意义(P＜0.05)。结论：采用芫苓消水散联合IL-2腹腔灌注治疗癌性腹水患者，效果满意，毒副反应少。

Abstract:: Objective： To observe clinical effects of YuanLing XiaoShui powder and intraperitoneal perfusion of IL-2 in treating malignant ascites. Methods: All 120 patients were randomized into the control group and the observation group, 60 cases each group, the control group adopted intraperitoneal perfusion of IL-2, the observation group used intraperitoneal perfusion of IL-2 and YuanLing XiaoShui powder for external application, after treating two weeks, to compare curative effects, TCM syndrome scores, abdominal perimeter, the depth of ascites, 24hour urinary volume, quality of life, toxic reactions between both groups. Results: Total effective rate of the control group was 65.0%, lower than 85.0% of the observation group, and the difference showed statistical meaning (P＜0.05). The difference had statistical meaning in the comparisons of abdominal perimeter, the depth of ascites, 24hour urinary volume, KPS scores and TCM syndrome scores within two groups before and after treating(P＜0.05); the difference was statistically significant in the comparisons between both groups after treating(P＜0.05). The observation group was lower than the control group in the incidences of toxic reactions except anemia, sick and vomiting(P＜0.05). Conclusion: YuanLing XiaoShui powder and intraperitoneal perfusion of IL-2 in treating malignant ascites could obtain satisfactory effects with minor toxic reactions.