加味定心汤联合坦度螺酮治疗广泛性焦虑障碍临床观察-《西部中医药》

文章信息/Info

Title:: Clinical Observation on Modified DingXin Decoction Combined with Tandospirone in Treating Generalized Anxiety Disorder

Author(s):: ZHOU Donglin1, MA Yuanye1, WEI Zhangli1, WANG Fang2; 1 Tianshui Municipality the Third People's Hospital, Tianshui 741000, China; 2 Tianshui Psychiatric Sanatorium of Retired Soldier

Keywords:: generalized anxiety disorder; modified DingXin decoction; tandospirone

摘要:: 目的：观察加味定心汤联合坦度螺酮治疗广泛性焦虑障碍心血亏虚证的临床疗效。方法：将广泛性焦虑障碍患者90例随机分为研究组和对照组各45例，研究组以加味定心汤联合坦度螺酮治疗，对照组用坦度螺酮治疗，观察期8周。用汉密尔顿焦虑量表(HAMA)评定疗效；用副反应量表(TESS)评定治疗中出现的不良反应。结果：有效率研究组为86.7%，对照组为66.7%，2组比较差异有统计学意义(P＜0.05)；从治疗第1周开始，HAMA评分下降研究组较对照组显著(P＜0.05)；TESS评分研究组为(3.25±1.55)分，对照组为(3.77± 1.86)分，2组比较差异无统计学意义(P＞0.05)；不良反应发生率2组比较差异无统计学意义(P＞0.05)。结论：加味定心汤联合坦度螺酮治疗心血亏虚型广泛性焦虑障碍疗效优于单纯坦度螺酮，且不良反应低。

Abstract:: Objective: To observe clinical effects of modified DingXin decoction joined with tandospirone in the treatment for generalized anxiety disorder of heart-blood depletion pattern. Methods: Ninety patients were randomized into the experiment group and the control group, 45 cases each group, the experiment group were treated by modified DingXin decoction joined with tandospirone, and the control group by tandospirone, the observation period was eight weeks. HAMA was applied to evaluate clinical effects; and TESS was used to assess adverse reactions. Results: The effective rate of the experiment group was 86.7%, higher than 66.7% of the control group, and the difference showed statistical meaning (P＜0.05). Since the first week of treating, the experiment group was more notable than the control group in the decrease of HAMA scores(P＜0.05); TESS scores of the experiment group were (3.25±1.55) points, while the scores of the control group were (3.77±1.86) points, the difference had no statistical meaning between both groups (P＞0.05); and the difference had no statistical meaning in the comparisons of the incidences between both groups (P＞0.05). Conclusion: Curative effects of modified DingXin decoction joined with tandospirone are superior to these of only tandospirone in the treatment for generalized anxiety disorder of heart-blood depletion pattern with lower incidences of adverse reaction.