[1]汪亚兰,韩宝侠△,苟小军,等.活血通脉胶囊联合前列地尔注射液治疗血栓闭塞性脉管炎疗效观察[J].西部中医药,2019,32(05):91-94.
　WANG Yalan,HAN Baoxia,GOU Xiaojun.Clinical Observation on HuoXue TongMai Capsules Combined with Alprostadil Injection in the Treatment for Thromboangiitis Obliterans[J].Western Journal of Traditional Chinese Medicine,2019,32(05):91-94.
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活血通脉胶囊联合前列地尔注射液治疗血栓闭塞性脉管炎疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年05期
页码:
91-94
栏目:
出版日期:
2019-05-15

文章信息/Info

Title:
Clinical Observation on HuoXue TongMai Capsules Combined with Alprostadil Injection in the Treatment for Thromboangiitis Obliterans
文章编号:
1004-6852(2019)05-0091-04
作者:
汪亚兰1，韩宝侠2△，苟小军3，
1 南京中医药大学附属医院/苏州市中医医院血管外科，江苏 苏州215100； 2 苏州大学附属第二医院血透室； 3 上海市宝山区中西医结合医院中心实验室
Author(s):
WANG Yalan1, HAN Baoxia2△, GOU Xiaojun3
1 Department of Vascular Surgery, Suzhou Hospital of Traditional Chinese Medicine/Afliliated Hospital of Nanjing University of Traditional Chinese Medicine, Suzhou 215100, China; 2 Hemodialysis Room, the Second Affiliated Hospital of Soochow University
关键词:
血栓闭塞性脉管炎; 活血通脉胶囊; 前列地尔注射液
Keywords:
thromboangiitis obliterans;  HuoXue TongMai capsules;  alprostadil injection
分类号:
R248
摘要:
目的：观察活血通脉胶囊联合前列地尔注射液治疗血栓闭塞性脉管炎(thromboangiitis obliterans，TAO)的临床疗效和安全性。方法：将血栓闭塞性脉管炎患者90例随机分为对照组和治疗组，各45例。对照组患者给予常规基础治疗以及前列地尔注射液治疗；治疗组患者在对照组治疗的基础上口服活血通脉胶囊，每日早中晚各1次。30天为1个疗程，2组均连续治疗2个疗程。观察2组患者临床疗效，治疗前后症状积分、血流变指标、最大行走距离、血管踝臂指数及不良反应发生情况。结果：治疗组患者临床总有效率为95.6%，高于对照组的84.2%，差异有统计学意义(P＜0.05)；治疗后治疗组各症状积分改善、血流变指标水平、最大行走距离、血管踝臂指数均优于对照组，差异有统计学意义(P＜0.05)；2组患者不良反应发生率比较差异无统计学意义(P＞O.05)。结论：活血通脉胶囊联合前列地尔注射液治疗TAO疗效优于前列地尔注射液，且未发生严重不良反应。
Abstract:
Objective: To observe clinical effects and the safety of HuoXue TongMai capsules and alprostadil injection in the treatment for thromboangiitis obliterans(TAO). Methods: All 90 patients were allocated to the control group and the treatment group randomly. The patients in the control group were given conventional basic therapy and alprostadil injection, and the ones in the treatment group took HuoXue TongMai capsules on the basis of the therapy the control group accepted, once in the morning, afternoon and evening. 30 days were one course, both groups were treated for two courses consecutively. To observe clinical effects, symptom scores before and after treating, hemorheological indexes, maximum walking distance, vascular ankle-brachial indexes and the conditions of adverse reactions in both groups. Results: Total effective rate of the treatment group was 95.6%, higher than 84.2% of the control group, and the difference showed statistical meaning (P＜0.05). After treating, the treatment group was superior to the control group in the improvement of different symptom scores, the levels of hemorheological index, maximum walking distance and vascular ankle-brachial indexes, and the difference showed statistical meaning (P＜0.05); the difference had no statistical meaning in the comparisons of adverse reactions between both groups(P＞0.05). Conclusion: HuoXue TongMai capsules and alprostadil injection in the treatment for TAO are superior to alprostadil injection, and no seveve adverse reaction happen.

相似文献/References:

[1]李骥,邢鹏超,赵诚,等.益气通脉片治疗血栓闭塞性脉管炎临床观察[J].西部中医药,2014,27(11):97.
[2]何国华,钞建峰.通闭益气活血汤治疗血栓闭塞性脉管炎的临床研究[J].西部中医药,2013,26(03):88.
　HE Guohua,CHAO Jianfeng.Clinical Study on TongBi YiQi HuoXueTang in the Treatment for Thromboangiitis Obliterans[J].Western Journal of Traditional Chinese Medicine,2013,26(05):88.
[3]柴守范,何国华.佛手益气活血汤对血栓闭塞性脉管炎模型大鼠TXB2、6-Keto-PGF1α、VEGF表达的影响[J].西部中医药,2014,27(11):14.

备注/Memo

备注/Memo:
收稿日期：2018-08-23 *基金项目：宝山区中西医结合医院院级基金(编号201610)。 作者简介：汪亚兰(1980—)，女，主管护师。研究方向：临床护理。 △通讯作者：韩宝侠(1981—)，女，主管护师。研究方向：临床护理。
更新日期/Last Update: 2019-05-15