小续命汤加减治疗急性缺血性中风疗效观察-《西部中医药》

文章信息/Info

Title:: Clinical Observation on Modified Xiaoxuming Decoction in the Treatment for Acute Ischemic Apoplexy

Author(s):: GUO Jieting, ZHU Genfu; The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510360, China

Keywords:: acute ischemic apoplexy; Xiaoxuming decoction; treatment; clinical study

摘要:: 目的：观察小续命汤加减治疗急性缺血性中风的近期及远期疗效。方法：将急性缺血性中风患者38例随机分为2组各19例，对照组使用西医常规治疗，治疗组在对照组治疗的基础上加服小续命汤加减治疗，连续治疗14天，随访3个月。治疗14天后采用中医证候积分量表、美国国立卫生院卒中量表(NIHSS评分)进行近期疗效评价。随访3个月后，使用Barthel指数(BI)、改良Rankin量表(mRS)进行残障功能及生活质量的远期疗效评价。结果：2组患者治疗后第14天的中医证候积分、NIHSS 评分与组内治疗前及治疗后组间比较差异均有统计学意义(P＜0.05)，而BI指数比较差异无统计学意义(P＞0.05)，在随访第30天、第90天的BI指数2组比较差异有统计学意义(P＜0.05)。2组在第14天，第30天，第90天的mRS评分比较差异有统计学意义(P＜0.05)。结论：小续命汤加减联合西医常规治疗能改善急性缺血性中风患者近期疗效及远期生活能力和生活质量。

Abstract:: Objective: To investigate short-term and long-term curative effect of Xiaoxuming decoction in the treatment for acute ischemic apoplexy. Methods: All 38 patients were randomized into two groups, 19 cases each group, the control group used conventional therapy of Western medicine, and the treatment group took Xiaoxuming decoction on the foundation of conventional therapy, for 14 days consecutively, and the patients were followed for three months. After treating for 14 days, TCM syndrome scores and NIHSS scores were used to assess short-term effects. After followed for three months, Barthel index (BI) and modified Rankin scores (mRS) were adopted to evaluate long-term effects of disability function and quality of life. Results: The difference had statistical meaning when TCM syndrome scores and NIHSS scores after treating for 14 days were compared with before treating within two groups and between both groups after treating(P＜0.05). The difference had no statistical meaning in BI between both groups (P＞0.05), the difference had statistical meaning in the comparisons of BI between both groups at the 30th day and 90th day of the follow-ups(P＜0.05). The difference was statistically significant in mRS scores between both groups at the 14th day, 30th day and 90th day of the follow-ups(P＜0.05). Conclusion: Modified Xiaoxuming decoction could improve short-term curative effects and long-term living ability and quality of the patients.