[1]李富萍,靳蕊蕊.醋酸甲地孕酮分散片联合固本止崩方治疗子宫内膜不典型增生疗效观察[J].西部中医药,2019,32(07):107-109.
　LI Fuping,JIN Ruirui.Observation on Clinical Effects of Megestrol Acetate Dispersible Tablets Combined with Guben Zhibeng Prescription in the Treatment for Atypical Hyperplasia of Endometrium[J].Western Journal of Traditional Chinese Medicine,2019,32(07):107-109.
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醋酸甲地孕酮分散片联合固本止崩方治疗子宫内膜不典型增生疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年07期
页码:
107-109
栏目:
出版日期:
2019-07-15

文章信息/Info

Title:
Observation on Clinical Effects of Megestrol Acetate Dispersible Tablets Combined with Guben Zhibeng Prescription in the Treatment for Atypical Hyperplasia of Endometrium
文章编号:
1004-6852(2019)07-0107-03
作者:
李富萍，靳蕊蕊
甘肃省妇幼保健院，甘肃 兰州 730050
Author(s):
LI Fuping, JIN Ruirui
Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730050, China
关键词:
子宫内膜不典型增生; 醋酸甲地孕酮分散片; 固本止崩方; 中西医结合
Keywords:
atypical hyperplasia of endometrium;  megestrol acetate dispersible tablets;  Guben Zhibeng prescription;  integrative medicine
分类号:
R271.9
文献标志码:
B
摘要:
目的：观察醋酸甲地孕酮分散片联合固本止崩方治疗子宫内膜不典型增生的临床效果。方法：将子宫内膜不典型增生患者150例采用随机数字表法分为观察组和对照组各75例。对照组采用醋酸甲地孕酮分散片治疗，观察组在对照组治疗的基础上联合中药固本止崩方治疗，观察2组患者有效率、复发率、病理转化率、子宫内膜厚度、促卵泡生长激素(FSH)水平和不良反应发生率。结果：观察组有效率为86.7%，高于对照组的69.3%(P＜0.05)；进展率观察组为4.0%，对照组为2.7%，2组比较差异无统计学意义(P＞0.05)；观察组病理转化率为78.7%，高于对照组的61.3%(P＜0.05)；观察组治疗后子宫内膜厚度为(3.12±0.39)mm，小于对照组的(4.24±0.41)mm(P＜0.05)；2组FSH水平均低于治疗前，且观察组低于对照组，差异有统计学意义(P＜0.05)；不良反应发生率观察组为18.67%，对照组为20%，2组比较差异无统计学意义(P＞0.05)。结论：醋酸甲地孕酮分散片联合中药固本止崩方治疗子宫内膜不典型增生的疗效优于单纯使用醋酸甲地孕酮分散片，且未增加不良反应发生率。
Abstract:
Objective: To observe clinical effects of megestrol acetate dispersible tablets combined with Guben Zhibeng prescription in the treatment for atypical hyperplasia of endometrium. Methods: A total of 150 patients were separated into the observation group and the control group in light of number table method, 75 cases each group. The control group was administrated with megestrol acetate dispersible tablets, the observation group took Guben Zhibeng prescription based on the therapy the control group accepted, to observe the incidence of adverse reaction, the levels of FSH, endometrium thickness, the transformation rate of pathological examination, the relapse rate and the effective rate between both groups. Results: The effective rate of the observation group was 86.7%, higher than 69.3% of the control group (P＜0.05); the progression rate of the observation group was 4.0%, higher than 2.7% of the control group, while the difference had no statistical meaning (P＞0.05); the transformation rate of pathological examinations in the observation group was 78.7%, higher than 61.3% of the control group(P＜0.05); endometrium thickness of the observation group after treating was(3.12±0.39)mm, smaller than(4.24±0.41)mm of the control group (P＜0.05); the levels of FSH in both groups were lower than before medication, and the observation group was lower than the control group, and the difference had statistical meaning (P＜0.05); the incidence of adverse reaction of the observation group was 18.67%, lower than 20% of the control group, and the difference had no statistical meaning (P＞0.05). Conclusion: Megestrol acetate dispersible tablets combined with Guben Zhibeng prescription are superior to only megestrol acetate dispersible tablets in the treatment for atypical hyperplasia of endometrium, and the combination therapy would not increase the incidence of adverse reaction.

相似文献/References:

[1]林志斌.中西医结合治疗子宫内膜不典型增生临床观察[J].西部中医药,2015,28(07):102.

备注/Memo

备注/Memo:
收稿日期：2018-02-27*基金项目：甘肃省卫生行业科研计划项目(编号GSWSKY2016-12)。作者简介：李富萍(1965—)，女，主任医师。研究方向：高危产科疾病的中西医结合诊治。
更新日期/Last Update: 2019-07-15