[1]张力旋,杨帅,金凯,等.电针对产后抑郁大鼠HPG轴相关激素的调控作用[J].西部中医药,2020,33(02):18-21.[doi:10.12174/j.issn.1004-6852.2020.02.05]
　ZHANG Lixuan,YANG Shuai,JIN Kai,et al.Regulatory Effects of Acusector on the Related Hormones of HPG Axis of the Rats with Postpartum Depression[J].Western Journal of Traditional Chinese Medicine,2020,33(02):18-21.[doi:10.12174/j.issn.1004-6852.2020.02.05]
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电针对产后抑郁大鼠HPG轴相关激素的调控作用
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年02期
页码:
18-21
栏目:
出版日期:
2020-02-15

文章信息/Info

Title:
Regulatory Effects of Acusector on the Related Hormones of HPG Axis of the Rats with Postpartum Depression
文章编号:
1004-6852(2020)02-0018-04
作者:
张力旋，杨帅，金凯，陈宛仪，秦丽娜
1 北京中医药大学第三附属医院，北京 100029； 2 北京市大兴区中西医结合医院
Author(s):
ZHANG Lixuan1, YANG Shuai2, JIN Kai1, CHEN Wanyi1, QIN Lina1△
1The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China;2Beijing Daxing District Hospital of Integrated Chinese and Western Medicine
关键词:
产后抑郁症; HPG轴; 促性腺激素释放激素; 卵泡刺激素; 促黄体生成素; 电针; 大鼠
Keywords:
postpartum depression;  HPG axis;  GnRH;  FSH;  LH;  acusector;  rats
分类号:
R714.46
DOI:
10.12174/j.issn.1004-6852.2020.02.05
文献标志码:
A
摘要:
目的：探讨电针对产后抑郁(postpartum depression，PPD)大鼠神经内分泌系统下丘脑-垂体-性腺(hypothalamus pituitary gonadal axis,HPG axis)轴相关激素的干预机制。方法：选用2～3月龄雌性SD大鼠60只，随机分为空白组、假手术组、模型组、电针组、西药组，每组12只，每组设2、4、6周观察时点。运用酶联免疫法检测上述时点大鼠血清HPG轴激素水平。结果：模型组各时点促性腺激素释放激素(gonadotropin-releasing hormone，GnRH)、卵泡刺激素(follicle stimulating hormone，FSH)、促黄体生成素(luteinizing hormone，LH)均较空白组、假手术组降低，差异有统计学意义(P＜0.05)；西药组及电针组各时点GnRH、FSH均较模型组升高，差异有统计学意义(P＜0.05)，LH均较模型组降低，差异有统计学意义(P＜0.05)。结论：电针百会、印堂对PPD大鼠神经内分泌系统HPG轴相关激素水平具有明显改善效果，其对PPD 的缓解作用可能与调节上述各激素的平衡密切相关。
Abstract:
Objective: To discuss the mechanism of acusector in the intervention of HPG axis - related hormone for the rats with postpartum depression (PPD). Methods: Sixty female SD rats were randomized into the blank group, sham operation group, the model group, acusector group and Western medicine group, 12 rats each group, all the groups were observed at the second, forth and sixth week. ELISA method was used to detect the levels of hormone related to HPG axis at the above points. Results: The levels of GnRH, FSH and LH of the model group reduced compared with the blank group and sham operation group at the above points, and the difference was statistically significant (P＜0.05); the levels of GnRH and FSH of Western medicine group and acusector group rose compared with the model group at the above points, and the difference showed statistical meaning (P＜0.05); the levels of LH in Western medicine group and acusector group lowered than the model group, and the difference showed statistical meaning (P＜0.05). Conclusion: Acusector at Baihui (GV20, DU20) and Yintang (GV29) could improve the levels of hormone related to HPG axis in PPD rats, and the effects of acusector on PPD might be closely related to regulating the balance of the above hormones.

相似文献/References:

[1]周红霞.心理支持联合穴位干预护理对产后抑郁症的影响[J].西部中医药,2014,27(09):139.

备注/Memo

备注/Memo:
收稿日期：2019-02-26*基金项目：北京中医药大学自主选题项目(2016-JYB-JSMS-081)。作者简介：张力旋(1992—)，女，在读硕士研究生。研究方向：针灸治疗神志病。通讯作者：秦丽娜(1978—)，女，博士学位，主任医师。研究方向：针灸治疗神志病的机理研究。
更新日期/Last Update: 2020-02-15