[1]靳贵林,米玛,杨春艳,等.藏药“矮紫堇”中有效成分含量测定及安全用药指导研究[J].西部中医药,2020,33(05):67-71.[doi:10.12174/j.issn.1004-6852.2020.05.19]
　JIN Guilin,MI Ma,YANG Chunyan,et al.Study on the Guidance of Safe Drug Use and Content Determination of Active Ingredients from Tibetan Medicine ″Aizijin″[J].Western Journal of Traditional Chinese Medicine,2020,33(05):67-71.[doi:10.12174/j.issn.1004-6852.2020.05.19]
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藏药“矮紫堇”中有效成分含量测定及安全用药指导研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年05期
页码:
67-71
栏目:
出版日期:
2020-05-15

文章信息/Info

Title:
Study on the Guidance of Safe Drug Use and Content Determination of Active Ingredients from Tibetan Medicine ″Aizijin″
文章编号:
1004-6852(2020)05-0067-05
作者:
靳贵林，米玛，杨春艳，陈正红，达瓦，冯明科，益西拉姆，罗珍，顿珠次仁
西藏藏医学院，西藏 拉萨 850000
Author(s):
JIN Guilin, MI Ma, YANG Chunyan, CHEN Zhenghong, DA Wa, FENG Mingke, YIXI Lamu, LUO Zhen, DUNZHU Ciren△
Tibetan Traditional Medical College, Lasa 850000, China
关键词:
矮紫堇; 液相色谱; 原阿片碱; 小檗碱; 含量
Keywords:
Aizjin;  liquid chromatography;  protoopioid base;  berberine;  contents
分类号:
R212
DOI:
10.12174/j.issn.1004-6852.2020.05.19
文献标志码:
A
摘要:
目的：以原阿片碱、小檗碱为指标性成分建立矮紫堇质量评价的液相色谱方法。方法：用乙腈-0.3%磷酸梯度洗脱，检测波长289 nm，进样量10 μL测定原阿片碱、小檗碱含量。结果：矮紫堇中原阿片碱及小檗碱含量分别在（1.715±0.041） mg/g、(1.767±0.047)mg/g范围内波动。结论：该方法建立的矮紫堇的质量评价体系方法简便，精准可行，其数据可作为制定矮紫堇药用安全标准的参考依据。
Abstract:
Objective: To establish the method of liquid chromatography for quality evaluation of Aizijin (herba corydalis) by taking protoopioid base and berberine as the indicator components. Methods: Acetonitrile-0.3% phosphoric acid were used as gradient elution, detection wavelength 289nm, sampling size 10μL, to detect the contents of protoopioid base and berberine. Results: The contents of protoopioid base and berberine fluctuated in the range of (1.715±0.041)mg/g and (1.767±0.047)mg/g respectively. Conclusion: The method for quality evaluation system of Aizijin is simple, convenient, accurate and feasible, and the data could provide reference basis for establishing safe medication standard of Aizijin.

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[2]顿珠次仁,陈正红,米玛,等.关于藏药矮紫堇有效成分及色谱图的研究[J].西部中医药,2020,33(04):55.[doi:10.12174/j.issn.1004-6852.2020.04.17]
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备注/Memo

备注/Memo:
收稿日期：2019-02-20*基金项目：2016年西藏自治区高校青年教师创新支持计划项目(QCZ2016-79)。作者简介：靳贵林(1989—)，男，硕士学位，讲师。研究方向：中药鉴定及质量评价。△通讯作者：顿珠次仁(1982—)，男，硕士学位，副教授。研究方向：药物化学分析。
更新日期/Last Update: 2020-05-15