[1]李晓昊,韦嵩,陈志煌,等.经筋微创疗法联合柳氮磺嘧啶治疗强直性脊柱炎疗效观察[J].西部中医药,2020,33(05):127-131.[doi:10.12174/j.issn.1004-6852.2020.05.36]
　LI Xiaohao,WEI Song,CHEN Zhihuang,et al.Clinical Observation on Minimally Invasive Tendon Therapy and Sulfasalazine in Treating AS[J].Western Journal of Traditional Chinese Medicine,2020,33(05):127-131.[doi:10.12174/j.issn.1004-6852.2020.05.36]
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经筋微创疗法联合柳氮磺嘧啶治疗强直性脊柱炎疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年05期
页码:
127-131
栏目:
出版日期:
2020-05-15

文章信息/Info

Title:
Clinical Observation on Minimally Invasive Tendon Therapy and Sulfasalazine in Treating AS
文章编号:
1004-6852(2020)05-0127-05
作者:
李晓昊，韦嵩，陈志煌，侯春福
南部战区总医院中医科，广东 广州 510010
Author(s):
LI Xiaohao, WEI Song, CHEN Zhihuang, HOU Chunfu
TCM Department, General Hospital of PLA Southern Theater Command, Guangzhou 510010, China
关键词:
强直性脊柱炎; 经筋微创疗法; 炎性因子; 临床疗效
Keywords:
ankylosing spondylitis;  minimally invasive tendon therapy;  inflammatory factors;  clinical effects
分类号:
R593
DOI:
10.12174/j.issn.1004-6852.2020.05.36
文献标志码:
B
摘要:
目的：观察经筋微创疗法联合柳氮磺嘧啶治疗强直性脊柱炎（ankylosing spondylitis，AS）的临床疗效及其对炎性因子的作用。方法：将AS患者276例随机分为对照组和治疗组各138例，两组均口服柳氮磺吡啶肠溶片，对照组加服美洛昔康片，治疗组加用经筋微创疗法，疗程均为12周。观察治疗前后两组患者血清C-反应蛋白(C-reaction protein，CRP)、肿瘤坏死因子α(tumor necrosis factor α，TNF-α)、白细胞介素4(interleukin-4，IL-4)、白细胞介素6(interleukin-6，IL-6)、白细胞介素10(interleukin-10，IL-10)、转化生长因子β(transforming growth factor-β，TGF-β)水平及中医证候积分、ASAS20、ASAS40达标率。结果：治疗后两组患者CRP、TNF-α、IL-6水平均较治疗前降低(P＜0.05)，治疗组较对照组降低更明显(P＜0.05)；两组治疗后IL-4、IL-10、TGF-β水平较治疗前升高(P＜0.05)，治疗组较对照组升高更明显(P＜0.05)；ASAS20、ASAS40达标率治疗组均高于对照组(P＜0.05)；两组治疗后中医证候积分均降低(P＜0.05)，治疗组较对照组降低更明显；中医证候总有效率治疗组为90.6%(116/128)，对照组为73.2%(93/127)，治疗组优于对照组(P＜0.05)。结论：经筋微创疗法联合柳氮磺嘧啶治疗AS临床疗效优于美洛昔康片联合柳氮磺嘧啶，其作用机制可能与调整体内炎性因子相关。
Abstract:
Objective: To investigate clinical effects of minimally invasive tendon therapy and sulfasalazine (SSZ) in the treatment of ankylosing spondylitis(AS) and its influence on inflammatory factors. Methods: All 276 AS patients were randomly allocated to 138 cases of the control group and 138 cases of the treatment group, both groups took SSZ enteric-coated tablets, the control group accepted meloxicam tablets, and the treatment group minimally invasive tendon therapy, the course was 12 weeks. To observe the levels of CRP, TNF-α, IL-4, IL-6, IL-10 and TGF-β, TCM syndrome integrals and standard-reaching rates of ASAS20 and ASAS40 before and after treating in both groups. Results: After treating, the levels of CRP, TNF-α and IL-6 in both groups lowered than before treating (P＜0.05), the decrease of the treatment group was more notable compared with that of the control group (P＜0.05); the levels of IL-4, IL-10 and TGF-β of both groups after treating rose than before treating (P＜0.05), the rise of the treatment group was more obvious compared with that of the control group (P＜0.05); the treatment group was higher than the control group in standard-reaching rates of ASAS20 and ASAS40(P＜0.05); TCM syndrome integrals of both groups reduced after treating(P＜0.05), the decrease of the treatment group was more notable compared with that of the control group; total effective rate of TCM syndrome of the treatment group was 90.6%(116/128), superior to 73.2%(93/127) of the control group(P＜0.05). Conclusion: Curative effects of minimally invasive tendon therapy and SSZ in the treatment of AS are superior to these of meloxicam tablets joined with SSZ, and its mechanism might be related to regulating internal inflammatory factors.

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备注/Memo

备注/Memo:
收稿日期：2019-09-27*基金项目：广东省科技计划项目(2016ZC0207)。作者简介：李晓昊(1975—)，男，硕士学位，副主任医师。研究方向：风湿病的中西医结合研究。
更新日期/Last Update: 2020-05-15