玉屏风颗粒联合湿疹洗液治疗小儿慢性湿疹疗效观察-《西部中医药》

文章信息/Info

Title:: Clinical Observation on Yupingfeng Granules and Eczema Lotion in Treating Chronic Eczema

Author(s):: WANG Jianming; Jingning County People′s Hospital, Jingning 743400, China

Keywords:: eczema in children; Yupingfeng granules; eczema lotion; clinical observation

摘要:: 目的：观察玉屏风颗粒联合湿疹洗液治疗小儿慢性湿疹的临床疗效。方法：将慢性湿疹患儿90例根据随机数字表法分为两组各45例，对照组外用丁酸氢化可的松乳膏，治疗组口服玉屏风颗粒联合外用湿疹洗液，两组疗程均为4周。观察两组患儿治疗前后湿疹处皮损面积、皮肤瘙痒程度积分、中医证候评分与外周血清中白细胞介素2(interleukin-2，IL-2)、白细胞介素6(interleukin-6，IL-6)及免疫球蛋白E(immuno globulin E，IgE)水平，记录不良反应及复发率。结果：治疗后两组患儿皮损面积、皮肤瘙痒程度积分和中医证候评分均低于治疗前(P＜0.05)，但组间比较差异无统计学意义（P＞0.05）；与治疗前及对照组治疗后比较，治疗组患儿IL-2、IL-6与IgE水平降低(P＜0.05)；两组复发率比较差异有统计学意义(P＜0.05)；不良反应比较差异无统计学意义（P＞0.05）。结论:玉屏风颗粒联合湿疹洗液治疗小儿湿疹不良反应小，疗效与丁酸氢化可的松乳膏相当。

Abstract:: Objective: To observe clinical effects of Yupingfeng granules and eczema lotion in the treatment of chronic eczema in children. Methods: All 90 children were randomized into two groups according to number table method, the control group used hydrocortisone butyrate ointment orally, and the treatment group oral Yupingfeng granules and eczema lotion for external application, the course was four weeks. To observe lesion area, pruritus score and TCM syndrome integrals of eczema between both groups, to record adverse reaction in children and the relapse rate. Results: After treating, lesion area, pruritus score and TCM syndrome integrals of both groups reduced compared with these before treating (P＜0.05), the difference had no statistical meaning (P＞0.05); compared with before treating, and the control group after treating, the levels of IL-2, IL-6 and IgE of the treatment group reduced (P＜0.05); the difference had statistical meaning in the relapse rate between both group (P＜0.05), the difference had no statistical meaning in adverse reaction(P＞0.05). Conclusion: Yupingfeng granules and eczema lotion show minor adverse reaction in the treatment of chronic eczema in children, and its effects are equivalent to these of hydrocortisone butyrate ointment.