[1]马润兴.疏肝健脾封髓汤治疗更年期综合征的临床疗效观察[J].西部中医药,2020,33(08):99-102.[doi:10.12174/j.issn.1004-6852.2020.08.26]
　MA Runxing.Clinical Effects of Shugan Jianpi Fengsui Tang in Treating Climacteric Syndrome[J].Western Journal of Traditional Chinese Medicine,2020,33(08):99-102.[doi:10.12174/j.issn.1004-6852.2020.08.26]
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疏肝健脾封髓汤治疗更年期综合征的临床疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年08期
页码:
99-102
栏目:
出版日期:
2020-08-15

文章信息/Info

Title:
Clinical Effects of Shugan Jianpi Fengsui Tang in Treating Climacteric Syndrome
文章编号:
1004-6852(2020)08-0099-04
作者:
马润兴
青海省交通医院中医科，青海 西宁 810001
Author(s):
MA Runxing
TCM Department, Qinghai Provincial Jiaotong Hospital, Xi′ning 810001, China
关键词:
更年期综合征; 疏肝健脾封髓汤; 临床疗效; 免疫机制
Keywords:
climacteric syndrome;  Shugan Jianpi Fengsui Tang;  clinical effects;  immunologic mechanism
分类号:
R749.4+2
DOI:
10.12174/j.issn.1004-6852.2020.08.26
文献标志码:
B
摘要:
目的：分析疏肝健脾封髓汤治疗更年期综合征的疗效及其免疫机制。方法：将124例更年期综合征患者随机分为两组。对照组63例，给予常规治疗；观察组61例，服用疏肝健脾封髓汤治疗。两组均治疗30天。观察两组治疗前后外周血T细胞亚群(CD4+、CD8+、NK及CD4+/CD8+)、免疫球蛋白［免疫球蛋白G(Immunoglobulin G，IgG)、免疫球蛋白A(Immunoglobulin A，IgA)、免疫球蛋白M(Immunoglobulin M， IgM)］、补体［补体3(complement 3，C3)、补体4(complement 4，C4)］、汉密尔顿抑郁量表(hamilton depression scale，HAMD)和焦虑量表(hamilton anxiety scale，HAMA)评分的变化情况，并比较两组疗效。结果：外周血CD4+、CD8+、CD4+/CD8+、NK、IgG、IgA、IgM、C3、C4、HAMD和HAMA评分治疗前两组比较，差异均无统计意义(P＞0.05)；外周血CD4+、CD8+、CD4+/CD8+、NK、IgG、IgA、IgM、C3和C4治疗后两组均有不同程度的增高(P＜0.05)，HAMD和HAMA评分两组均有不同程度的降低(P＜0.05)，与对照组比，观察组外周血CD4+、CD8+、CD4+/CD8+、NK、IgG、IgA、IgM、C3和C4均明显增高(P＜0.05)，上述指标治疗后两组比较，差异均有统计学意义(P＜0.05)。总有效率对照组为73.02%(46/63)，观察组为90.16%(55/61)，两组比较差异有统计学意义(P＜0.05)。潮热汗出、五心烦热、腰膝酸软、头晕耳鸣等中医症状评分治疗前两组比较，差异无统计学意义(P＞0.05)；治疗后两组均明显降低，治疗前后组内比较差异有统计学意义(P＜0.05)，治疗后组间比较，差异也有统计学意义(P＜0.05)。结论：疏肝健脾封髓汤可用于治疗更年期综合征，其机制可能与改善患者免疫功能密切相关。
Abstract:
Objective: To analyze clinical effects of Shugan Jianpi Fengsui Tang in the treatment for climacteric syndrome and its immunologic mechanism. Methods: All 124 patients were randomized into two groups. 63 cases of the control group accepted conventional therapy; 61 cases of the observation group took Shugan Jianpi Fengsui Tang. Both groups were treated for 30 days. To observe the changes of T lymphocyte subsets (CD4+, CD8+, NK and CD4+/CD8+) in peripheral blood, immunoglobulin (IgG, IgA and IgM) and complements (C3 and C4), HAMD and HAMA before and after treating in both groups, to compare clinical effects between of both groups. Results: The difference had no statistical meaning in CD4+, CD8+, CD4+/CD8+, NK, IgA, IgM, C3, C4, HAMD and HAMA scores before treating between both groups (P＞0.05); CD4+, CD8+, CD4+/CD8+, NK, IgG, IgA, IgM, C3 and C4 in peripheral blood rose to different degrees after treating in both groups (P＜0.05), HAMD and HAMA socres reduced to different degrees in both groups (P＜0.05), compared with the control group, the levels of CD4+, CD8+, CD4+/CD8+, NK, IgG, IgA, IgM, C3 and C4 of the observation group increased notably (P＜0.05), the difference was statistically significan′t in these indexes between both groups after treating (P＜0.05), total effective rate of the control group was 73.02% (46/63), lower than 90.16% (55/61) of the observation group, and the difference showed statistical meaning (P＜0.05). The difference showed no statistical meaning in the scores of TCM symptoms including hectic fever and sweating, dysphoria in chest, palms and soles, soreness and weakness of waist and knees, dizziness and tinnitus before treating between both groups (P＞0.05); after treating, these scores lowered notably in both groups, and the difference showed statistical meaning within both groups before and after treating (P＜0.05), after treating, the difference showed statistical meaning between both groups (P＜0.05). Conclusion: Shugan Jianpi Fengsui Tang could improve immunologic function in the treatment for the patients with climacteric syndrome.

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备注/Memo

备注/Memo:
收稿日期：2019-09-28作者简介：马润兴(1977—)，男，副主任医师。研究方向：内科疾病的中医诊治。
更新日期/Last Update: 2020-08-15