百蕊颗粒联合干扰素雾化吸入治疗儿童疱疹性咽峡炎临床观察-《西部中医药》

文章信息/Info

Title:: Clinical Observation on Bairui Granules Joined with Interferon Atomization Inhalation in Treating Herpangina in Children

Author(s):: ZENG Yingying; Chengmai County People’s Hospital, Chengmai 571900, China

摘要:: 目的观察百蕊颗粒联合干扰素雾化吸入治疗儿童疱疹性咽峡炎的临床疗效。方法将疱疹性咽峡炎患儿180例随机分为两组各90例，对照组在基础治疗的同时给予利巴韦林注射液静脉滴注，观察组在对照组治疗的基础上口服百蕊颗粒联合注射用重组人干扰素α1b雾化吸入。观察两组临床疗效及疱疹、退热、疼痛、流涎消失时间，平均住院时间及免疫因子免疫球蛋白A(immunoglobulin A，IgA)、免疫球蛋白M(immunoglobulin M，IgM)、免疫球蛋白G(immunoglobulin G，IgG)水平。结果总有效率观察组为97.78%，优于对照组的88.89%；治疗后观察组患儿疱疹、退热、疼痛、流涎消失时间和平均住院时间均短于对照组（P＜O.05），治疗后两组患儿血清IgA、IgM、IgG水平均高于治疗前（P＜O.05），观察组高于对照组（P＜O.05）。结论在基础治疗的同时给予百蕊颗粒联合干扰素雾化吸入治疗儿童疱疹性咽峡炎疗效肯定，临床症状消失快。

Abstract:: ObjectiveTo survey clinical effects of Bairui granules and interferon atomization inhalation in treating herpangina in children. MethodsAll 180 children were randomized into two groups, 90 cases in each group, the control group accepted intravenous dripping of ribavirin injection based on conventional therapy, and the observation group oral administration of Bairui granules and recombinant human interferon for injection α 1B nebulization. To observe clinical effects, the disappearing time of herpes, fever, pain and salivation, mean length of hospital stay, the levels of IgA, IgM and IgG in two groups. ResultsTotal effective rate of the observation group was 97.78%, superior to 88.89% of the control group; after treating, the observation group was shorter than the control group in the disappearing time of herpes, fever, pain and salivation, mean length of hospital stay (P<0.05), after treating, the levels of IgA, IgM and IgG of both groups were higher than these before treating (P<0.05), and the observation group was higher than the control group (P<0.05). ConclusionBased on conventional therapy, oral administration of Bairui granules and interferon atomization inhalation could gain definite clinical effects in the treatment for herpangina in children, and clinical symptoms disappear quickly.