[1]王祺,蒋磊.加味桃核承气汤治疗2型糖尿病血瘀脉络证疗效及对血管内皮功能、血清炎症因子的影响[J].西部中医药,2022,35(07):6-10.[doi:10.12174/j.issn.2096-9600.2022.07.02]
　WANG Qi,JIANG Lei.Clinical Effects of Modified Taohe Chengqi Tang in the Treatment of Type Two Diabetes Mellitus of Blood Stasis in Collaterals Pattern and Its Influence on Vascular Endothelial Function, Serum Inflammatory Factors[J].Western Journal of Traditional Chinese Medicine,2022,35(07):6-10.[doi:10.12174/j.issn.2096-9600.2022.07.02]
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加味桃核承气汤治疗2型糖尿病血瘀脉络证疗效及对血管内皮功能、血清炎症因子的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年07期
页码:
6-10
栏目:
临床论著
出版日期:
2022-07-15

文章信息/Info

Title:
Clinical Effects of Modified Taohe Chengqi Tang in the Treatment of Type Two Diabetes Mellitus of Blood Stasis in Collaterals Pattern and Its Influence on Vascular Endothelial Function, Serum Inflammatory Factors
作者:
王祺, 蒋磊
安徽省第二人民医院，安徽 合肥 230041
Author(s):
WANG Qi, JIANG Lei
Anhui No.2 Provincial People's Hospital, Hefei 230041, China
关键词:
2型糖尿病; 血瘀脉络证; 血管内皮功能; 血清炎症因子; 加味桃核承气汤
Keywords:
T2DM; blood stasis in collaterals pattern; vascular endothelial function; serum inflammatory factors; modified
分类号:
R587.1
DOI:
10.12174/j.issn.2096-9600.2022.07.02
文献标志码:
A
摘要:
目的探讨加味桃核承气汤治疗2型糖尿病（type 2 diabetic mellitus，T2DM）血瘀脉络证的疗效及其对血管内皮功能、血清超敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）、白细胞介素6（interleukin-6，IL-6）水平的影响。 方法将T2DM血瘀脉络证患者124例采用随机数字表法分为对照组和观察组各62例，对照组予二甲双胍+阿卡波糖等常规支持治疗与饮食和运动等健康指导，观察组在对照组基础上服用加味桃核承气汤，两组均治疗24周。观察两组患者治疗前后血清炎症因子（hs-CRP、TNF-α、IL-6）水平、血管内皮功能［一氧化氮（nitric oxide，NO）和内皮素1（endothelin-1，ET-1）］、血糖指标［糖化血红蛋白（glycosylated hemoglobin，HbAlc）、空腹血糖（fasting plasma glucose，FPG）、餐后2 h血糖（2-hour postprandial blood glucose，2 h PG）］、中医症状评分等变化情况以及临床疗效和不良反应发生情况。 结果治疗后两组患者血清hs-CRP、IL-6、TNF-α水平及FPG、2 h PG、HbA1c水平与中医症状评分均较治疗前下降，观察组低于对照组（P＜0.05）；治疗后两组患者ET-1水平较治疗前下降，NO水平较治疗前升高，观察组ET-1下降、NO升高均优于对照组（P＜0.05）；观察组总有效率为96.77%（60/62），高于对照组的85.48%（53/62）（P＜0.05）；治疗期间对照组不良反应发生率为11.29%，高于观察组的6.45%（P＞0.05）。 结论加味桃核承气汤联合二甲双胍+阿卡波糖可有效抑制T2DM血瘀脉络证患者炎症反应，改善血管内皮功能，降低血糖和中医症状评分，并且安全性较高。
Abstract:
ObjectiveTo explore clinical effects of modified Taohe Chengqi Tang in the treatment of T2DM of blood stasis in collaterals pattern and its influence on the levels of vascular endothelial function, hs-CRP and TNF-α as well as IL-6. MethodsA total of 124 cases of T2DM of blood stasis in collaterals pattern were divided into the control group and the observation group according to random number table method, with 62 cases in each group. The control group accepted metformin+acarbose and other conventional supportive treatment, and health guidance of diet and exercise, the observation group took modified Taohe Chengqi Tang based on the therapy the control group received, both groups were treated for 24 weeks. To observe the levels of serum inflammatory factors [hs-CRP, TNF-α, IL-6], vascular endothelial function [NO and ET-1], the indexes of blood glucose [HbAlc, FPG, 2 h PG], TCM symptoms scores, clinical effects and the incidence of adverse reaction before and after treating between both groups. ResultsAfter the treatment, the levels of serum hs-CRP, IL-6 and TNF-α, FPG, 2 h PG and HbA1c and TCM symptoms scores lowered compared with these before treating, and the observation group was lower than the control group (P<0.05); after the treatment, the level of ET-1 in both groups decreased than that before treating, the level of NO increased than that before treating, the decrease of ET-1 and the increase of NO in the observation group were superior to these of the control group (P<0.05); total effective rate of the observation group was 96.77% (60/62), higher than 85.48% (53/62) of the control group (P<0.05); during therapeutic period, the incidence of adverse reaction of the control group was 11.29%, higher than 6.45% of the observation group (P>0.05). ConclusionModified Taohe Chengqi Tang combined with metformin+acarbose in the treatment of T2DM of blood stasis in collaterals pattern could effectively inhibit inflammatory reaction, improve vascular endothelial function, reduce blood glucose and TCM symptoms scores with higher safety.

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备注/Memo

备注/Memo:
王祺（1983—），男，硕士学位，主管药师。研究方向：医院药学。2018年度安徽高校自然科学研究重点项目（KJ2018C0298）。
更新日期/Last Update: 2022-07-15