[1]马雪娇,王学谦,吴晋芳,等.基于Apriori算法和因子分析挖掘肺癌分子靶向治疗中医用药配伍规律[J].西部中医药,2022,35(07):53-57.[doi:10.12174/j.issn.2096-9600.2022.07.14]
　MA Xuejiao,WANG Xueqian,WU Jinfang,et al.Medication Rules of TCM Therapy Combined with Molecular Targeted Therapy for Lung Cancer Based on Apriori Algorithm and Factor Analysis[J].Western Journal of Traditional Chinese Medicine,2022,35(07):53-57.[doi:10.12174/j.issn.2096-9600.2022.07.14]
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基于Apriori算法和因子分析挖掘肺癌分子靶向治疗中医用药配伍规律
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年07期
页码:
53-57
栏目:
调查分析
出版日期:
2022-07-15

文章信息/Info

Title:
Medication Rules of TCM Therapy Combined with Molecular Targeted Therapy for Lung Cancer Based on Apriori Algorithm and Factor Analysis
作者:
马雪娇1, 王学谦2, 吴晋芳3, 林洪生1
1.北京中医药大学，北京 100029
2.中国中医科学院广安门医院
3.广东省第二中医院
Author(s):
MA Xuejiao1, WANG Xueqian2, WU Jinfang3, LIN Hongsheng1
1.Beijing University of Chinese Medicine, Beijing 100029, China
2.Guang'anmen Hospital, China Academy of Chinese Medical Sciences
3.Guangdong Second Traditional Chinese Medicine Hospital
关键词:
肺癌; 分子靶向治疗; 数据挖掘; 用药规律; 五治五养; 林洪生
Keywords:
lung cancer; molecular targeted therapy; data mining; medication laws; five cures and five nurtures
分类号:
R289
DOI:
10.12174/j.issn.2096-9600.2022.07.14
文献标志码:
A
摘要:
目的运用数据挖掘法探讨林洪生教授“五治五养”中医康复理念指导下的肺癌分子靶向治疗中医用药配伍规律，总结“五治五养”的中医康复理念。 方法采集林洪生教授诊治肺癌的有效病例，从中提取200个中药处方，利用 Excel建立数据库并进行中药频数与频率分析，应用SPSS Modeler 18.0软件分析基于Apriori算法的关联规则，应用SPSS 24.0软件进行聚类分析。 结果林洪生教授采用中医药配合肺癌分子靶向治疗中中药高频药物为红景天、土茯苓、天冬、焦白术、麦冬、鸡血藤、白芍、佛手、金荞麦、灵芝等，共计40味，出现频次占81.90%。Apriori算法共得到置信度均为100%的29个药对，因子分析降维后得出14个因子，通过该结果总结出扶正祛邪，益气固表，润燥养阴，益气养阴，健脾止泻，行气解郁，养血活血，清热养阴等治法。通过因子分析还得到补血活血，活血行气，利水消肿，化痰止咳，平肝熄风，和中化痰等治法。 结论林洪生教授临床将“五治五养”贯穿于肺癌治疗的始终，中医药配合分子靶向治疗肺癌以中医防护治疗为基本原则，多从肺脾两脏出发，以扶正固本为纲领要略，稍加祛邪之品以增强西药的敏感性与疗效。
Abstract:
ObjectiveTo discuss the medication rules of TCM therapy and molecular targeted therapy for lung cancer under the guidance of professor Lin Hongsheng's TCM rehabilitation concept of "five cures and five nurtures" using data mining method, and to summarize TCM rehabilitation concept of "five cures and five nurtures". MethodsAfter collecting professor Lin Hongsheng's proven cases and extracting 200 herbal prescriptions, the database was established using Excel and perform the herbal frequency analysis, SPSS Modeler 18.0 software was used to analyze the association rules based on Apriori algorithm, SPSS 24.0 was used to perform cluster analysis. ResultsIn professor Lin Hongsheng's TCM therapy, high-frequency herbs were Hongjingtian (Rhodiolae crenulatae radix et rhizoma), Tufuling (Smilacis glabrae rhizoma), Tiandong (Asparagi radix), Jiaobaizhu (Atractylodis macrocephalae rhizoma), Maidong (Ophiopogonis Radix), Jixueteng (Spatholobi Caulis), Baishao (Paeoniae radix alba), Foshou (Citri sarcodactylis fructus), Jinqiaomai (Fagopyri dibotryis rhizoma) and Lingzhi (Ganoderma), 40 herbs altogether, the frequency held 81.90%. A total of 29 drug pairs with 100% confidence were obtained by Apriori algorithm; 14 factors were obtained by factor analysis after dimensionality reduction; therapeutic methods of enhancing healthy Qi and eliminating the evil, reinforcing Qi and consolidating the exterior, moistening the dryness and nourishing Yin, benefiting Qi and nourishing Yin, invigorating spleen and relieving diarrhea, promoting Qi circulation and resolving depression, nourishing blood and activating blood, clearing heat and nourishing Yin, among others were summarized by both methods. Therapeutic methods of tonifying blood and promoting blood circulation, activating blood and promoting Qi circulation, inducing diuresis to alleviate edema, reducing phlegm and stopping coughing, calming liver and relieving the dizziness, regulating the middle energizer and resolving phlegm were gained by factor analysis. ConclusionProfessor Lin Hongsheng adopts "five cures and five nurtures" throughout the treatment of lung cancer in clinic, takes TCM protection and treatment as the basic principle for TCM therapy combined with molecular targeted treatment of lung cancer, mostly starting from lung and spleen, and chooses enhancing the healthy Qi and consolidating the root as the guiding principles, he supplements the drugs of eliminating the evils to enhance the sensitivity and clinical effects of Western medicine therapy.

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备注/Memo

备注/Memo:
马雪娇（1997—），女，在读硕士研究生。研究方向：肿瘤疾病的中西医结合防治。国家中医药管理局中医药行业科研专项（201307006）。
更新日期/Last Update: 2022-07-15