[1]郭胜男,张莉,吴深涛,等.典型黄酮类化合物改善胰岛素抵抗研究进展[J].西部中医药,2022,35(11):144-148.[doi:10.12174/j.issn.2096-9600.2022.11.30]
　GUO Shengnan,ZHANG Li,WU Shentao,et al.Research Progress of Typical Flavonoids Improving Insulin Resistance[J].Western Journal of Traditional Chinese Medicine,2022,35(11):144-148.[doi:10.12174/j.issn.2096-9600.2022.11.30]
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典型黄酮类化合物改善胰岛素抵抗研究进展
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年11期
页码:
144-148
栏目:
出版日期:
2022-11-15

文章信息/Info

Title:
Research Progress of Typical Flavonoids Improving Insulin Resistance
作者:
郭胜男1, 张莉2, 吴深涛1, 刘弘毅3
1.天津中医药大学第一附属医院内分泌科，天津 300380
2.天津河东盛世众康医院中医科
3.云南中医药大学第一附属医院内分泌科
Author(s):
GUO Shengnan1, ZHANG Li2, WU Shentao1, LIU Hongyi3
1.Endocrinology Department, First Teaching Hospital of Tianjin University of TCM, Tianjin 300380, China
2.TCM Department, Hedong District Shengshi Zhongkang Hospital
3.Endocrinology Department, The First Affiliated Hospital of Yunnan University of Chinese Medicine
关键词:
2型糖尿病; 胰岛素抵抗; 黄酮类化合物; 黄芩苷; 黄芩素; 槲皮素; 芦丁
Keywords:
type two diabetes mellitus; insulin resistance; flavonoids; baicalin; baicalein; quercetin; rutin
分类号:
R284.2
DOI:
10.12174/j.issn.2096-9600.2022.11.30
文献标志码:
A
摘要:
选取黄酮类化合物中4种典型的化合物黄芩苷、黄芩素、槲皮素和芦丁，就其改善胰岛素抵抗（insulin resistence，IR）的作用及机制进行综述，指出这4种黄酮类化合物主要通过降糖、降脂、抗炎、抗氧化、影响胰岛素信号通路、改善内质网应激等方式改善IR，治疗2型糖尿病，未来临床可以黄酮类化合物作为抗糖尿病药物进行开发应用。
Abstract:
The action of improving IR and the mechanism of four typical flavonoids including baicalin, baicalein, quercetin and rutin were summarized after they were chosen, it was pointed out that the four flavonoids could improve IR and treat type two diabetes mellitus (T2DM) mainly by lowering the glucose and lipid, anti-inflammatory effects, oxidation resistance, affecting insulin signaling pathway, and improving endoplasmic reticulum stress, in the future, flavonoids could be developed and utilized as antidiabetic drug in clinic.

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备注/Memo

备注/Memo:
郭胜男（1989—），女，博士学位，主治医师。研究方向：糖尿病及其并发症的中西医结合防治。国家自然科学基金地区基金（81760856）；云南省应用基础研究计划青年项目（2017FD174）；云南省应用基础研究计划中医联合面上项目（2018FF001-053）。
更新日期/Last Update: 2022-11-15