[1]吴红英,许光兰,陈小丽,等.清金化痰汤治疗痰热郁肺型哮喘慢阻肺重叠临床研究[J].西部中医药,2023,36(06):103-105.[doi:10.12174/j.issn.2096-9600.2023.06.24]
　WU Hongying,XU Guanglan,CHEN Xiaoli,et al.Clinical Study on Qingjin Huatan Decoction in the Treatment of Phlegm-heat Stagnating in Lung Pattern ACO[J].Western Journal of Traditional Chinese Medicine,2023,36(06):103-105.[doi:10.12174/j.issn.2096-9600.2023.06.24]
点击复制

清金化痰汤治疗痰热郁肺型哮喘慢阻肺重叠临床研究

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年06期
页码:
103-105
栏目:
出版日期:
2023-06-15

文章信息/Info

Title:
Clinical Study on Qingjin Huatan Decoction in the Treatment of Phlegm-heat Stagnating in Lung Pattern ACO
作者:
吴红英1, 许光兰2, 陈小丽1, 陈青蓝1, 明春玉1
1.广西中医药大学，广西 南宁 530001
2.广西中医药大学第一附属医院，广西 南宁 530001
Author(s):
WU Hongying1, XU Guanglan2, CHEN Xiaoli1, CHEN Qinglan1, MING Chunyu1
1.Guangxi University of Chinese Medicine, Nanning 530001, China
2.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, China
关键词:
哮喘慢阻肺重叠; 清金化痰汤; 痰热郁肺; 临床研究
Keywords:
asthma-COPD overlap; decoction; phlegm-heat stagnating in lung; clinical study
分类号:
R563
DOI:
10.12174/j.issn.2096-9600.2023.06.24
文献标志码:
B
摘要:
目的观察清金化痰汤对痰热郁肺型哮喘慢阻肺重叠的临床疗效。 方法将60例哮喘慢阻肺重叠患者，按照随机数字表法分为观察组和对照组，每组30例。两组均予布地奈德福莫特罗吸入剂治疗，观察组加服清金化痰汤，疗程4周。比较两组肺功能［第一秒用力呼气容积（forced expiratory volume in one second，FEV1）/用力肺活量（forced vital capcacity，FVC）］、呼出气一氧化氮 （fractional expired nitric oxide，FeNO）、血清炎症因子水平［白细胞介素4（interleukin 4，IL-4）、白细胞介素6（interleukin 6，IL-6）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）］。 结果治疗后，两组FEV1值、FEV1/FVC较治疗前增高，FeNO、IL-4、IL-6、TNF-α水平降低（P＜0.05）；且观察组各项指标水平改善优于对照组（P＜0.05）。观察组总有效率［96.67%（29/30）］高于对照组［86.67%（26/30）］（P＜0.05）。 结论清金化痰汤可有效改善哮喘慢阻肺重叠痰热郁肺患者的肺功能、减轻炎症反应，提高临床疗效。
Abstract:
ObjectiveTo observe clinical effects of Qingjin Huatan decoction in the treatment of asthma-COPD overlap (ACO) of phlegm-heat stagnating in lung pattern. MethodsSixty ACO patients were allocated to the observation group and the control group according to random number table method, 30 cases in each group. Both groups were treated by budesonide and formoterol fumarate powder for inhalation, the observation group took Qingjin Huatan decoction, and the course was four weeks. To compare pulmonary function [FEV1/FVC], FeNO, the levels of serum inflammatory factor [IL-4, IL-6 and TNF-α] between both groups. ResultsAfter the treatment, FEV1 and FEV1/FVC increased in the two groups, the levels of FeNO, IL-4, IL-6 and TNF-α reduced (P<0.05); and the improvements of different indexes of the observation group were better than these of the control group (P<0.05). Total effective rate of the observation group was [96.67%(29/30)], higher than [86.67%(26/30)] of the control group (P<0.05). ConclusionQingjin Huatan decoction could effectively improve lung function, relieve inflammatory reaction and raise clinical effects in the treatment ofACO of phlegm-heat stagnating in lung pattern.

相似文献/References:

[1]问莉娜,郭珍,赵欢,等.清金化痰汤对卒中相关性肺炎患者的影响[J].西部中医药,2020,33(04):93.[doi:10.12174/j.issn.1004-6852.2020.04.28]
　WEN Lina,GUO Zhen,ZHAO Huan,et al.Effects of Qingjin Huatan Tang on Stroke-associated Pneumonia Patients[J].Western Journal of Traditional Chinese Medicine,2020,33(06):93.[doi:10.12174/j.issn.1004-6852.2020.04.28]
[2]杨浩,张康,谢凯,等.清金化痰汤加减辅助治疗重症肺炎有效性及安全性的Meta分析[J].西部中医药,2025,38(05):60.[doi:10.12174/j.issn.2096-9600.2025.05.12]
　YANG Hao,ZHANG Kang,XIE Kai,et al.Meta-analysis of the Effectiveness and Safety of Modified Qinjin Huatan Decoction as Adjuvant Therapy for Severe Pneumonia[J].Western Journal of Traditional Chinese Medicine,2025,38(06):60.[doi:10.12174/j.issn.2096-9600.2025.05.12]

备注/Memo

备注/Memo:
吴红英（1994—），女，在读硕士研究生。研究方向：呼吸系统疾病的中西医结合防治。国家自然科学基金（81760848，81360534）。
更新日期/Last Update: 2023-06-15