基于“脑肠轴”理论探讨脑肠肽、肠道菌群与缺血性中风的联络机制-《西部中医药》

文章信息/Info

Title:: Exploration into the Relationship among Braingut Peptide, Intestinal Flora and Ischemic Stroke Based on "Brain-Gut Axis"

Author(s):: SU Ping, ZHU Meizhen, SUN Shijie, WEI Liang; Guangxi University of Traditional Chinese Medicine, Nanning 530001, China

Keywords:: ischemic stroke; brain-gut axis; brain gut peptides; intestinal flora

摘要:: 基于中医脑肠互动理论，以肠道菌群为切入点，脑肠肽为切入面，脑肠轴为重要通路探讨缺血性中风与脑肠肽和肠道菌群相互作用的联络机制，指出脑肠轴为大脑与胃肠道的重要通路，脑与肠生理上息息相关，病理上互相影响，脑病及肠，肠病及脑，是中医学整体思维的创新与发展，也是中医整体观的体现。基础和临床研究发现，脑肠肽、肠道菌群与缺血性中风的发生发展密切联系，但他们之间的作用机制仍需进一步挖掘，需要更多循证医学证据支持，从而为缺血性脑血管疾病的防治提供新的研究思路和理论参考。

Abstract:: The relationship among braingut peptide, intestinal flora and ischemic stroke was discussed on the foundation of brain-gut interaction theory in TCM, with intestinal flora as the point of penetration and braingut peptide as the approaching side and brain-gut axis as the important pathway, braingut axis is the important path for brain and gastrointestinal tract, brain and the intestine are closely related in physiology, affecting each other in pathology, cerebral disease affecting the intestine and the intestinal disease involving the brain, which is the innovation and development of holism concept in TCM, embodying the concept of holism in TCM. In basic and clinical studies, braingut peptide and intestinal flora are closely related to the attack and development of ischemic stroke, however, the acting mechanism among them needs to be further explored and supported with more evidence-based medicine evidence, thereby providing new research ideas and theoretical reference for the prevention and the treatment of ischemic cerebrovascular diseases.