[1]闫瑞娟,李京涛,魏海梁,等.小肝癌患者不同中医证型与临床指标的相关性研究[J].西部中医药,2023,36(10):100-103.[doi:10.12174/j.issn.2096-9600.2023.10.21]
　YAN Ruijuan,LI Jingtao,WEI Hailiang,et al.Study on the Correlation between TCM Patterns and Clinical Indexes of Small Liver Cancer[J].Western Journal of Traditional Chinese Medicine,2023,36(10):100-103.[doi:10.12174/j.issn.2096-9600.2023.10.21]
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小肝癌患者不同中医证型与临床指标的相关性研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年10期
页码:
100-103
栏目:
出版日期:
2023-10-15

文章信息/Info

Title:
Study on the Correlation between TCM Patterns and Clinical Indexes of Small Liver Cancer
作者:
闫瑞娟1, 李京涛1, 魏海梁1, 闫曙光2, 惠毅2, 刘永刚1, 常占杰1
1.陕西中医药大学附属医院，陕西 咸阳 712000
2.陕西中医药大学，陕西 咸阳 712000
Author(s):
YAN Ruijuan1, LI Jingtao1, WEI Hailiang1, YAN Shuguang2, HUI Yi2, LIU Yonggang1, CHANG Zhanjie1
1.Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
2.Shaanxi University of Chinese Medicine, Xianyang 712000, China
关键词:
小肝癌; 中医证型; 临床指标; 相关性研究
Keywords:
small liver cancer; TCM patterns; clinical indexes; correlational study
分类号:
R735.7
DOI:
10.12174/j.issn.2096-9600.2023.10.21
文献标志码:
A
摘要:
目的分析小肝癌患者不同中医与患者基线情况、肝功能、血常规、凝血及肿瘤系列的关系。 方法通过回顾性研究，收集2016年1月至2019年12月在陕西中医药大学附属医院肝病科确诊为小肝癌的135例患者，分析不同中医证型患者的基线资料，并探讨与肝功能［丙氨酸氨基转移酶（alanine aminotransferase，ALT）、天门冬氨酸氨基转移酶（aspartate aminotransferase，AST）、γ-谷氨酰基转移酶（γ-glutamyl transpeptadase，GGT）、碱性磷酸酶（alkaline phosphatase，ALP）、白蛋白（albumin，ALB）、球蛋白（globulin，GLO）、总胆红素（total bilirubin，TBIL）］；血常规［白细胞计数（white blood cell count，WBC）、红细胞计数（red blood cell count，RBC）、血红蛋白（haemoglobin，HGB）、血小板（platelet，PLT）］；凝血系列［血浆凝血酶原时间测定（prothrombin time，PT）、凝血酶原活度（prothrombin time activity，PTA）、部分活化凝血酶时间（activated partial thromboplastin time，APTT）、血浆纤维蛋白原测定（fibrinogen，Fbg）］及肿瘤系列等的相关性。 结果135例小肝癌患者中，脾虚肝损瘀毒型最多［42.96%（58/135）］，且中医证型与TBIL、ALB、RBC、HGB、Fbg、PT相关（P＜0.05），与年龄、性别、家族史、饮酒史、吸烟史、病毒感染情况、ALT、AST、GGT、ALP、GLO、WBC、PLT、PTA、APTT、肿瘤系列无明显相关性。 结论小肝癌的中医证型分布具有明显差异，且各证型与一些临床指标之间存在相互关系，应被重视及进一步研究。
Abstract:
ObjectiveTo analyze the correlations between TCM patterns of small liver cancer and the patients' baseline conditions, liver function, blood routine, blood coagulation and tumor markers. MethodsThrough retrospective study, the information of 135 patients diagnosed with small liver cancer was collected in the Department of Liver Diseases of the Affiliated Hospital of Shaanxi University of Chinese Medicine from January 2016 to December 2019, to analyze different patterns patients' baseline data, and discuss the connections with liver function (ALT, AST, GGT, ALP, ALB, GLO, TBIL), blood routine (WBC, RBC, HGB, PLT), blood coagulation (PT, PTA, APTT, Fbg) and tumor makers (AFP, CEA, Ferritin, CA199,CA125). ResultsAmong 135 patients, most of the patients belonged to the pattern of spleen deficiency, liver damage and blood stasis pattern [42.96%(58/135)], and TCM patterns were related to TBIL, ALB, RBC, HGB, Fbg and PT (P<0.05), while showed no obvious correlation with age, gender, family history, history of drinking, history of smoking, viral infection, ALT, AST, GGT, ALP, GLO, WBC, PLT, PTA, APTT and tumor markers. ConclusionSignificant difference exists in the distribution of TCM patterns of small liver cancer, the correlativity could be found between different patterns and some clinical indexes, which should be taken seriously and further studied.

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备注/Memo

备注/Memo:
闫瑞娟（1990—），女，硕士学位，主治医师。研究方向：肝癌的中医药干预。陕西省科技厅科研基金（2016SF-234，2018KJXX-093，2022JQ-965）；陕西省中医药管理局科研基金（15-JC009）；陕西中医药大学学科创新团队建设项目（2019-YL05）。
更新日期/Last Update: 1900-01-01