[1]夏小军,段赟,雷旭东,等.中医药辅助治疗肺癌455例疗效观察[J].西部中医药,2023,36(10):120-124.[doi:10.12174/j.issn.2096-9600.2023.10.25]
　XIA Xiaojun,DUAN Yun,LEI Xudong,et al.Observation on Clinical Effects of Adjuvant Therapy of TCM in Treating 455 Cases of Lung Cancer[J].Western Journal of Traditional Chinese Medicine,2023,36(10):120-124.[doi:10.12174/j.issn.2096-9600.2023.10.25]
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中医药辅助治疗肺癌455例疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年10期
页码:
120-124
栏目:
出版日期:
2023-10-15

文章信息/Info

Title:
Observation on Clinical Effects of Adjuvant Therapy of TCM in Treating 455 Cases of Lung Cancer
作者:
夏小军, 段赟, 雷旭东, 陈浩方, 李亚红, 郭炳涛
甘肃省肿瘤医院，甘肃 兰州 730050
Author(s):
XIA Xiaojun, DUAN Yun, LEI Xudong, CHEN Haofang, LI Yahong, GUO Bingtao
Gansu Cancer Hospital, Lanzhou 730050, China
关键词:
肺癌; 化积汤系列方; 清金消积膏; 扶金化积膏; 中西医结合; 增效减毒; 疗效; 生存期
Keywords:
lung cancer; series of prescriptions of decoction; ointment; oint-ment; integrated Chinese and Western medicine; synergism and toxicity reduction; clinical effects; survival period
分类号:
R734
DOI:
10.12174/j.issn.2096-9600.2023.10.25
文献标志码:
B
摘要:
目的观察中医药辅助治疗对肺癌的疗效及生存期的影响。 方法将948例肺癌患者，分为对照组493例和观察组455例；对照组治疗按照《恶性肿瘤中医诊疗指南》推荐的方法；观察组在“指南”治疗的基础上增加中医药辅助治疗，依据辨证分型，分别采用自拟中药化积汤系列方加减，或采用清金消积膏、扶金化积膏治疗。 结果总有效率观察组［80.00%（308/385）］高于对照组［51.84%（240/463）］，差异有统计学意义（P＜0.05）。观察组癌胚抗原（Carcinoembryonic antigen，CEA）、糖类抗原125（Carbohydrate antigen 125，CA125）水平较对照组明显降低（P＜0.05）。观察组（Karnofsky，KPS）60分下降比例比对照组少，差异有统计学意义（P＜0.05）。观察组发生不良反应及并发症总数比对照组少，差异有统计学意义（P＜0.05）。观察组3年生存率27.98%，对照组为26.95%。观察组平均生存期26.43个月，中位生存期32个月，对照组平均生存期25.04个月，中位生存期27个月；观察组2年生存率53.61%，对照组47.01%。 结论自拟中药化积汤系列方及清金消积膏、扶金化积膏辅助治疗肺癌，具有明显的增效减毒作用，并可改善患者的生活质量，延长生存期。
Abstract:
ObjectiveTo observe the influence of adjuvant therapy of TCM on therapeutic effects and survival period of lung cancer. MethodsAll 948 patients were randomized into 493 cases of the control group and 455 cases of the observation group; the control group was treated according to the method recommended in TCM diagnosis and treatment guidelines of malignant tumors; on the foundation of the therapy of the guidelines, the observation group added TCM adjuvant therapy, adopting a series of modified prescriptions of selfmade Huaji decoction, or Qingjin Xiaoji ointment, Fujin Huaji ointment respectively in light of syndrome differentiation and treatment. ResultsTotal effective rate of the observation group was [80.00%(308/385)], higher than [51.84%(240/463)] of the control group, and the difference had statistical meaning (P<0.05). The levels of CEA and CA125 of the observation group reduced remarkably than the control group (P<0.05). The decline ratio of KPS 60 points in the observation group was less than that in the control group, and the difference showed statistical meaning (P<0.05). Total number of adverse reactions and complications in the observation group was less than that in the control group (P<0.05). Three-year survival rate of the observation group was 27.98%, while lower than 26.95% of the control group. Mean survival time of the observation group was 26.43 months, median survival time was 32 months, longer than 25.04 months and 27 months of the control group; two-year survival rate of the observation group was 53.61%, higher than 47.01% of the control group. ConclusionTCM adjuvant therapy therapy, containing a series of prescriptions of Huaji decoction, Qingjin Xiaoji ointment and Fujin Huaji ointment, in the treatment of lung cancer have significant synergistic and toxicity-reducing effects, which could improve the patients' quality of life and prolong survival period.

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备注/Memo

备注/Memo:
夏小军（1965—），男，主任医师，教授，博士研究生导师。研究方向：肿瘤血液病的中西医结合诊治。甘肃省中医药管理局（GZKZD-2018-03）。
更新日期/Last Update: 1900-01-01