[1]李丽博,劳慧敏,陈梦琦,等.中医药逆转支气管哮喘上皮间质转化相关信号通路研究概述[J].西部中医药,2024,37(07):72-75.[doi:10.12174/j.issn.2096-9600.2024.07.17]
　LI Libo,LAO Huimin,CHEN Mengqi,et al.Summary of TCM Therapy for Reversal of Signalling Pathway Related to Epithelial Mesenchymal Transformation in Bronchial Asthma[J].Western Journal of Traditional Chinese Medicine,2024,37(07):72-75.[doi:10.12174/j.issn.2096-9600.2024.07.17]
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中医药逆转支气管哮喘上皮间质转化相关信号通路研究概述
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年07期
页码:
72-75
栏目:
研究进展
出版日期:
2024-07-15

文章信息/Info

Title:
Summary of TCM Therapy for Reversal of Signalling Pathway Related to Epithelial Mesenchymal Transformation in Bronchial Asthma
作者:
李丽博1, 劳慧敏2, 陈梦琦1, 刘宣妤1
1.山东中医药大学，山东 济南 250355
2.山东中医药大学附属医院，山东 济南 250011
Author(s):
LI Libo1, LAO Huimin2, CHEN Mengqi1, LIU Xuanyu1
1.Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2.Affiliated Hospital to Shandong University of Traditional Chinese Medicine, Jinan 250011, China
关键词:
哮喘; 上皮间质转化; 气道重塑; 中医药; 信号通路
Keywords:
asthma; epithelial mesenchymal transformation; airway remodeling; traditional Chinese medicine; signaling pathway
分类号:
R562.2+5
DOI:
10.12174/j.issn.2096-9600.2024.07.17
文献标志码:
A
摘要:
从上皮间质转化相关信号通路入手，介绍中医药通过上皮间质转化途径调控哮喘气道重塑的研究概况，认为多条信号通路的介导都会诱发上皮间质转化的进行性加重。实验研究证实，中医药通过多通路、多靶点的介导在治疗哮喘中发挥重要作用，且单味药及单剂方都会对疾病产生多靶点干预能力，为研究中医药防治哮喘的作用机制提供参考和思路。
Abstract:
Starting from the signaling pathway related to epithelial mesenchymal transformation, we introduce the overview of the study on TCM therapy for the regulation of asthma airway remodelling via epithelial mesenchymal transformation, it is believed that the mediation of many signaling pathways could induce progres-sive aggravation of epithelial mesenchymal transformation, many experimental researches have confirmed the therapeutic effects of TCM, it plays the decisive role in the treatment of asthma via the mediation of many pathways and targets. Single herb and single prescription will have multi-target intervention ability for diseases, which could provide the reference and thinking for the mechanism of TCM therapy for asthma.

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备注/Memo

备注/Memo:
李丽博（1996—），女，硕士学位。研究方向：小儿呼吸系统疾病的临床研究。国家自然科学基金青年基金项目（81904143）；山东省自然科学基金面上项目（ZR2022MH081）；山东省中医药科技发展计划项目（2019-0124）；济南市临床医学科技创新计划（202019153）；山东中医药大学附属医院青年名中医项目（2022）。
更新日期/Last Update: 2024-07-15