[1]蒋桂平,曹会波,王正银.健脾化痰活血汤对甲状腺功能减退症患者甲状腺功能及临床疗效的影响[J].西部中医药,2024,37(07):131-135.[doi:10.12174/j.issn.2096-9600.2024.07.31]
　JIANG Guiping,CAO Huibo,WANG Zhengyin.Influence of Spleen-invigorating Phlegm-resolving Blood-activating Decoction on Thyroid Function in Patients with Hypothyroidism and Curative Effects[J].Western Journal of Traditional Chinese Medicine,2024,37(07):131-135.[doi:10.12174/j.issn.2096-9600.2024.07.31]
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健脾化痰活血汤对甲状腺功能减退症患者甲状腺功能及临床疗效的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年07期
页码:
131-135
栏目:
临床研究
出版日期:
2024-07-15

文章信息/Info

Title:
Influence of Spleen-invigorating Phlegm-resolving Blood-activating Decoction on Thyroid Function in Patients with Hypothyroidism and Curative Effects
作者:
蒋桂平1, 曹会波2, 王正银1
1.滁州市来安家宁医院,安徽 滁州 239200
2.安徽中医药大学附属滁州中西医结合医院,安徽 滁州 239000
Author(s):
JIANG Guiping1, CAO Huibo2, WANG Zhengyin1
1.Chuzhou Lai'an Jia'ning Hospital, Chuzhou 239200, China
2.Chuzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Anhui University of Chinese Medicine, Chuzhou 239000, China
关键词:
甲状腺功能减退症; 健脾化痰活血汤; 左甲状腺素钠片; 甲状腺功能
Keywords:
hypothyroidism; spleen-invigorating phlegm-resolving blood-activating decoction; levothyroxine sodium tablets; thyroid function
分类号:
R581.2
DOI:
10.12174/j.issn.2096-9600.2024.07.31
文献标志码:
B
摘要:
目的观察健脾化痰活血汤对甲状腺功能减退症患者甲状腺功能及临床疗效的影响。 方法以61例甲状腺功能减退症患者为研究对象，采用随机数字表法分为对照组（30例）和观察组（31例）。对照组采用左甲状腺素钠片进行治疗，观察组在对照组的基础上采用健脾化痰活血汤进行治疗，两组均治疗12周。统计两组临床疗效，比较两组治疗前后症状积分、生活质量评分及甲状腺功能、血脂代谢指标。 结果治疗后观察组总有效率为93.55%（28/31），高于对照组的73.33%（22/30）（P＜0.05）。治疗后两组症状积分均明显降低（P＜0.05），且观察组低于对照组（P＜0.05）；生活质量评分两组均明显升高（P＜0.05），且观察组高于对照组（P＜0.05）。治疗后两组血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇、促甲状腺激素、抗甲状腺球蛋白抗体、甲状腺过氧化物酶抗体水平降低（P＜0.05），且观察组低于对照组（P＜0.05）；两组血清高密度脂蛋白胆固醇、游离三碘甲状腺原氨酸、游离甲状腺素水平升高（P＜0.05），且观察组高于对照组（P＜0.05）。 结论健脾化痰活血汤治疗甲状腺功能减退症，可有效减轻患者临床症状，改善甲状腺功能及血脂代谢水平，提高患者生活质量。
Abstract:
ObjectiveTo observe the impacts of spleen-invigorating phlegm-resolving blood-activating decoction on thyroid function in patients with hypothyroidism and curative effects. MethodsA total of 61 patients were chosen as the research objects, and divided into the control group (n=30 cases) and the observation group (n=31 cases) using random number table method. The control group was treated with levothyroxine sodium tablets, and the observation group took spleen-invigorating phlegm-resolving blood-activating decoction orally based on the therapy of the control group, both groups were treated for 12 weeks. To compare curative effects of the two groups, to compare symptom scores, the scores of quality of life, the indexes of thyroid function and lipid meta-bolism before and after treatment in both groups. ResultsAfter treatment, total effective rate of the observation group was 93.55% (28/31), higher than 73.33%(22/30) of the control group (P<0.05). After the treatment, symptom scores of both groups reduced obviously in the two groups (P<0.05), and the observation group was lower than the control group (P<0.05); the scores of quality of life increased evidently in the two groups (P<0.05), and the observation group was higher than the control group (P<0.05). After the treatment, the levels of trigly-cerides, total cholesterol, LDL-C, thyroid stimulating hormone, antithyroglobulin antibodies, and thyroid pero-xidase antibodies lowered in the two groups (P<0.05), and the observation group was lower than the control group (P<0.05); the levels of high-density lipoprotein cholesterol, free triiodothyronine, and free thyroxine increased in both groups (P<0.05), and the observation group was higher than the control group (P<0.05). ConclusionSpleen-invigorating phlegm-resolving blood-activating decoction in the treatment of patients with hypothyroidism could effectively relieve clinical symptoms, improve the levels of thyroid function, and lipid metabolism, as well as the patients' quality of life.

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[1]尚靖智,袁岳鹏,刘淑妍.温补脾肾汤联合左甲状腺素钠片治疗甲状腺功能减退症临床观察[J].西部中医药,2021,34(06):106.[doi:10.12174/j.issn.2096-9600.2021.06.26]
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备注/Memo

备注/Memo:
蒋桂平（1983—），女，副主任医师。研究方向：内科疾病的中医药治疗。安徽省中医药传承创新科研项目（2022CCTB10）。
更新日期/Last Update: 2024-07-15