[1]邢宇,单海军,袁慧敏.健脾疏肝熄风汤治疗脾虚肝亢型小儿多发性抽动症临床研究[J].西部中医药,2024,37(11):121-123.[doi:10.12174/j.issn.2096-9600.2024.11.26]
　XING Yu,SHAN Haijun,YUAN Huimin.Clinical Study on Spleen-invigorating Liver-soothing Wind-extinguishing Decoction in the Treatment of Pediatric Multiple Tourette Disease of Spleen-deficiency Liver-hyperactivity Pattern[J].Western Journal of Traditional Chinese Medicine,2024,37(11):121-123.[doi:10.12174/j.issn.2096-9600.2024.11.26]
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健脾疏肝熄风汤治疗脾虚肝亢型小儿多发性抽动症临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年11期
页码:
121-123
栏目:
临床研究
出版日期:
2024-11-15

文章信息/Info

Title:
Clinical Study on Spleen-invigorating Liver-soothing Wind-extinguishing Decoction in the Treatment of Pediatric Multiple Tourette Disease of Spleen-deficiency Liver-hyperactivity Pattern
作者:
邢宇1, 单海军2, 袁慧敏3
1.河南中医药大学，河南 郑州 450046
2.河南中医药大学第二附属医院，河南 郑州 450053
3.信阳市平桥区妇幼保健院,河南信阳 464095
Author(s):
XING Yu1, SHAN Haijun2, YUAN Huimin3
1.Henan University of Chinese Medicine, Zhengzhou 450046, China
2.Henan Province Hospital of TCM, Zhengzhou 450053, China
3.Pingqiao District Maternal and Child Health Care Hospital, Xinyang 464095, China
关键词:
多发性抽动症; 健脾疏肝熄风汤; 脾虚肝亢证; 耶鲁抽动症整体严重程度量表; 小儿
Keywords:
multiple tourette disease; spleen-invigorating liver-soothing wind-extinguishing decoction; spleen deficiency liver-hyperactivity pattern; YGTSS; children
分类号:
R272.6
DOI:
10.12174/j.issn.2096-9600.2024.11.26
文献标志码:
B
摘要:
目的探讨健脾疏肝熄风汤治疗脾虚肝亢型小儿多发性抽动症（multiple tourette disease，MTD）的临床疗效。 方法将62例MTD患儿随机分为对照组和观察组，每组各31例。对照组予硫必利片治疗，观察组在此基础上予健脾疏肝熄风汤内服治疗，两组均连续治疗12周。治疗结束后，比较两组耶鲁抽动症整体严重程度量表（yale global tic severity scale，YGTSS）评分、脾虚肝亢证单项症状评分的变化情况，以及临床疗效、中医证候疗效和不良反应发生情况。 结果治疗后两组YGTSS评分、脾虚肝亢证单项症状评分均降低（P＜0.05），且观察组降低程度大于对照组（P＜0.05）；临床总有效率观察组［96.77%（30/31）］高于对照组［74.19%（23/31）］（P＜0.05）；中医证候疗效总有效率观察组［100.00%（31/31）］高于对照组［80.65%（25/31）］（P＜0.05）；不良反应发生率观察组［9.68%（3/31）］低于对照组［22.58%（7/31）］（P＜0.05）。 结论健脾疏肝熄风汤治疗脾虚肝亢型小儿MTD疗效明显，能控制疾病发展，改善中医证候，降低不良反应发生率。
Abstract:
ObjectiveTo survey curative effects of spleen-invigorating liver-soothing wind-extinguishing decoction in the treatment of pediatric multiple tourette disease (MTD) of spleen deficiency liver-hyperactivity pattern. MethodsAll 62 MTD children were randomized into the control group and the observation group with 31 cases in each. The control group was treated with tiapride hydrochloride tablets, and the observation group took the decoction orally based on Western medicine, both groups were treated for 12 weeks continuously. By the end of the treatment, to compare the scores of YGTSS, the scores of single symptom of spleen deficiency liver-hyperactivity pattern, clinical effects, curative effects of TCM syndromes and the incidences of adverse reactions between both groups. ResultsAfter the treatment, YGTSS scores and the scales of single symptom of spleen deficiency liver-hyperactivity pattern reduced in the two groups (P<0.05), and the decrease of the observation group was greater than that of the control group (P<0.05). Clinical total effective rate of the observation group was [96.77%(30/31)], higher than [74.19%(23/31)] of the control group (P<0.05); Total effective rate of the efficacy of TCM syndromes of the observation group was [100.00%(31/31)], higher than [80.65%(25/31)] of the control group; the incidences of adverse reaction of the observation group was [9.68%(3/31)], lower than [22.58%(7/31)] of the control group (P<0.05). ConclusionSpleen-invigorating liver-soothing wind-extinguishing decoction could gain obvious clinical effects in the treatment of pediatric MTD of spleen deficiency liver-hyperactivity pattern, control the development of disease, improve TCM syndromes and lower the incidence of adverse reactions.

相似文献/References:

[1]杨志华,马融,张喜莲.基于“司揣内外”理论探讨小儿多发性抽动症[J].西部中医药,2015,28(11):42.
[2]高汉媛,史正刚△,尚菁,等.菖蒲郁金汤对TS模型大鼠行为及纹状体单胺类神经递质的影响[J].西部中医药,2017,30(11):28.
　GAO Hanyuan,SHI Zhenggang,et al.The Effects of ChangPu YuJin Decoction on the Behavior and Monoamine Neurotransmitter in Corpus Striatum of TS Rat Model[J].Western Journal of Traditional Chinese Medicine,2017,30(11):28.
[3]曹晓芳.心理干预联合耳穴压豆治疗儿童多发性抽动症临床观察[J].西部中医药,2017,30(11):120.
　CAO Xiaofang.Clinical Observation on Psychological Intervention Combined with Auricular Pressure in the Treatment for the Children with Tourette Syndrome[J].Western Journal of Traditional Chinese Medicine,2017,30(11):120.

备注/Memo

备注/Memo:
邢宇（1991—），女，主治医师。研究方向：小儿神经系统疾病的中医药防治。E-mail：xingyu910915@163.com。河南省自然科学基金（210100410092）。
更新日期/Last Update: 2024-11-15