[1]茹晖晖.解毒化瘀汤联合曲安奈德口腔软膏治疗口腔扁平苔藓30例[J].西部中医药,2024,37(11):142-145.[doi:10.12174/j.issn.2096-9600.2024.11.31]
　RU Huihui.Treatment of Oral Lichen Planus with Detoxification and Stagnation-resolving Decoction Combined with Triamcinolone Acetonide Dental Paste: 30 Cases[J].Western Journal of Traditional Chinese Medicine,2024,37(11):142-145.[doi:10.12174/j.issn.2096-9600.2024.11.31]
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解毒化瘀汤联合曲安奈德口腔软膏治疗口腔扁平苔藓30例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年11期
页码:
142-145
栏目:
衷中参西
出版日期:
2024-11-15

文章信息/Info

Title:
Treatment of Oral Lichen Planus with Detoxification and Stagnation-resolving Decoction Combined with Triamcinolone Acetonide Dental Paste: 30 Cases
作者:
茹晖晖
甘肃省第二人民医院,甘肃兰州730030
Author(s):
RU Huihui
Second Provincial People's Hospital of Gansu, Lanzhou730030, China
关键词:
口腔扁平苔藓; 曲安奈德口腔软膏; 解毒化瘀汤; 口腔黏膜病损面积; 免疫因子
Keywords:
oral lichen planus; triamcinolone acetonide dental paste; detoxification and stagnation-resolving decoction; the area of oral mucosa lesion; immune factors
分类号:
R276.8
DOI:
10.12174/j.issn.2096-9600.2024.11.31
文献标志码:
B
摘要:
目的观察曲安奈德口腔软膏联合解毒化瘀汤治疗口腔扁平苔藓的临床疗效。 方法回顾性选取口腔扁平苔藓患者60例，依据不同用药方法分为观察组与对照组，每组30例。观察组采用曲安奈德口腔软膏联合解毒化瘀汤治疗，对照组采用曲安奈德口腔软膏治疗。观察两组临床疗效、口腔疼痛程度、口腔黏膜病损面积、症状评分、炎症因子、免疫因子水平及复发情况。 结果观察组总有效率［96.67%（29/30）］高于对照组［73.33%（22/30）］（P＜0.05）；治疗后观察组数字分级评分法评分、口腔黏膜病损面积均小于对照组（P＜0.05）；治疗后观察组症状评分、白细胞介素6（interleukin，IL-6）、IL-8、IL-10、肿瘤坏死因子α（tumor necrosis factor，TNF-α）水平及CD8+均低于对照组（P＜0.05），CD4+、CD4+/CD8+均高于对照组（P＜0.05）；观察组复发率［23.33%（7/30）］低于对照组［53.33%（16/30）］（P＜0.05）。 结论曲安奈德口腔软膏联合解毒化瘀汤治疗口腔扁平苔藓，可缩小口腔黏膜病损面积，降低炎性指标水平，提高临床疗效，降低复发率。
Abstract:
ObjectiveTo observe clinical effects of triamcinolone acetonide dental paste and detoxification and stagnation-resolving decoction in the treatment of oral lichen planus. MethodsSixty patients were retro-spectively chosen and divided into the observation group and the control group according to the medication methods, 30 cases in each group, the observation group was treated with triamcinolone acetonide dental paste and detoxification and stagnation-resolving decoction, and the control group accepted triamcinolone acetonide dental paste. To observe clinical efects, oral pain degrees, the area of oral mucosa lesion, symptom scores, the levels of inflammatory factor and immune factor, and the recurrence conditions between the two groups. ResultsTotal effe-ctive rate of the observation group was [96.67%(29/30)], higher than [73.33%(22/30)] of the control group (P<0.05); after the treatment, the observation group was less than the control group in numerical rating scale (NRS) scores and the lesion area of oral mucosa (P<0.05); after the treatment, symptom scores, the levels of IL-6, IL-8, IL-10 and TNF-α, as well as CD8+ of the observation group were lower than these of the control group (P<0.05), the levels of CD4+, CD4+ /CD8+ were higher than these of the control group (P<0.05). The relapse rate of the observation group was [23.33%(7/30)], lower than [53.33%(16/30)] of the control group (P<0.05). ConclusionTriamcinolone acetonide dental paste and detoxification and stagnation-resolving decoction in the treatment of oral lichen planus could reduce the lesion area of oral mucosa, lower the levels of inflammatory factors, and raise curative effects, as well as decrease the recurrence rate.

相似文献/References:

[1]马小胜,吴佳璇△,薛春玲.综合疗法治疗肝郁气滞型口腔扁平苔藓36例[J].西部中医药,2014,27(10):104.
[2]马俊,马华安,陈国丰.陈国丰教授从浊邪论治口腔扁平苔藓[J].西部中医药,2022,35(02):45.[doi:10.12174/j.issn.2096-9600.2022.02.11]
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备注/Memo

备注/Memo:
茹晖晖（1971—），女，副主任医师。研究方向：口腔黏膜病的诊治及研究。E-mail：13893374691@139.com。
更新日期/Last Update: 2024-11-15