[1]吴健,付彤飞,袁军.百令胶囊联合ACEI/ARB治疗慢性肾小球肾炎的Meta分析[J].西部中医药,2024,37(12):60-64.[doi:10.12174/j.issn.2096-9600.2024.12.15]
　WU Jian,FU Tongfei,YUAN Jun.Meta-Analysis of Bailing Capsules Combined with ACEI/ARB in the Treatment of Chronic Glomerulonephritis[J].Western Journal of Traditional Chinese Medicine,2024,37(12):60-64.[doi:10.12174/j.issn.2096-9600.2024.12.15]
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百令胶囊联合ACEI/ARB治疗慢性肾小球肾炎的Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年12期
页码:
60-64
栏目:
二次研究
出版日期:
2024-12-15

文章信息/Info

Title:
Meta-Analysis of Bailing Capsules Combined with ACEI/ARB in the Treatment of Chronic Glomerulonephritis
作者:
吴健1, 付彤飞2, 袁军2,3,4
1.恩施土家族苗族自治州中心医院,湖北恩施 445000
2.湖北中医药大学，湖北 武汉 430000
3.湖北省中医院，湖北 武汉 430000
4.湖北省中医药研究院，湖北 武汉 430000
Author(s):
WU Jian1, FU Tongfei2, YUAN Jun2,3,4
1.The Central Hospital of Enshi Tujia and Miao Autonomous Perfecture, Enshi Tujia and Miao Autonomous Perfecture 445000, China
2.Hubei University of Chinese Medicine, Wuhan 430000, China
3.Hubei Provincial Hospital of TCM, Wuhan 430000, China
4.Hubei Provincial Institute of TCM, Wuhan 430000, China
关键词:
肾小球肾炎; 慢性; 百令胶囊; 血管紧张素转换酶抑制剂; 血管紧张素Ⅱ受体拮抗剂; Meta分析
Keywords:
glomerulonephritis;  chronic; capsules; ACEI; ARB; Meta-analysis
分类号:
R256.5
DOI:
10.12174/j.issn.2096-9600.2024.12.15
文献标志码:
A
摘要:
目的系统评价百令胶囊联合血管紧张素转换酶抑制剂（angiotensin-converting enzyme inhibitor，ACEI）或血管紧张素Ⅱ受体拮抗剂（angiotensin Ⅱ receptor blockers，ARB）治疗慢性肾小球肾炎（chronic glomerulonephritis，CGN）的有效性及安全性。 方法检索中国期刊全文数据库（CNKI）、万方数据知识服务平台数据库、维普中文科技期刊全文数据库（VIP）、中国生物医学文献服务系统（SinoMed）、PubMed及Cochrane Library数据库中有关百令胶囊联合ACEI或ARB治疗CGN的随机临床对照试验，检索年限范围从各数据库建库至2021年4月，对满足纳入和排除标准的文献进行质量评价及信息提取，采用RevMan 5.3软件进行Meta分析。 结果共纳入文献19篇，包括2157例患者。Meta分析结果显示：与对照组相比，百令胶囊联合ACE或ARB在提高CGN患者临床有效率（OR=3.93，95%CI：2.98～5.19，P＜0.000 01），降低血肌酐（MD=-16.36，95%CI：-22.28～-10.44，P＜0.000 01），减少尿素氮（MD=-1.54，95%CI：-1.63～-1.46，P＜0.000 01），降低24 h尿蛋白定量（MD=-0.40，95%CI：-0.43～-0.38，P＜0.000 01）等方面优于对照组。 结论百令胶囊联合ACEI或ARB能够提高CGN患者临床疗效，在降低血肌酐、减少尿素氮、降低24 h尿蛋白定量等方面优于单用ACEI或ARB治疗。
Abstract:
ObjectiveTo systematically assess the effectiveness and the safety of Bailing capsules combined with ACEI/ARB in the treatment of chronic glomerulonephritis (CGN). MethodsClinical randomised controlled trials (RCTs) of Bailing capsules combined with ACEI/ARB in the treatment of CGN were searched from CNKI, Wanfang, VIP, SinoMed, Pubmed and Cochrane library, the period of search ranged from the establishment of the database to April 2021, the quality evluation and information extraction of the documents that met the inclusion and exclusion criteria were carried out, and Meta-analysis was performed using RevMan 5.3 software. ResultsAll 19 papers were included, involving 2157 patients. Meta-analysis results displayed that: compared with the control group, Bailing capsules combined with ACEI/ARB were better than the control gorup in improving clinical effective rate in CGN patients (OR=3.93, 95%CI:2.98～5.19, P<0.000 01), reducing SCr (MD=-16.36, 95%CI:-22.28～-10.44, P<0.000 01), lowering urea nitrogen (MD=-1.54, 95%CI:-1.63～-1.46], P<0.000 01), and decreasing the quantification of 24 h-proteinuria (MD=-0.40, 95%CI:-0.43～-0.38, P<0.000 01). ConclusionBailing capsules combined with ACEI/ARB could enhance clinical effects in the treatment of CGN, it is better than single use of ACEI or ARB in decreasing SCr, urea nitrogen and the quantification of 24 h-proteinuria.

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备注/Memo

备注/Memo:
吴健（1992—），男，硕士学位，医师。研究方向：肾脏疾病的中医药防治。湖北省自然科学基金（2019CFB619）；湖北省卫生健康委员会科研项目（WJ2021M180）。
更新日期/Last Update: 2024-12-15