[1]张丽平,李维燕,董俊刚,等.紫草油外用治疗成人失禁相关性皮炎的Meta分析[J].西部中医药,2024,37(12):82-85.[doi:10.12174/j.issn.2096-9600.2024.12.19]
　ZHANG Liping,LI Weiyan,DONG Jungan,et al.External Application of Comfrey Oil in the Treatment of Adult Incontinence-associated Dermatitis: a Meta Analysis[J].Western Journal of Traditional Chinese Medicine,2024,37(12):82-85.[doi:10.12174/j.issn.2096-9600.2024.12.19]
点击复制

紫草油外用治疗成人失禁相关性皮炎的Meta分析
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年12期
页码:
82-85
栏目:
二次研究
出版日期:
2024-12-15

文章信息/Info

Title:
External Application of Comfrey Oil in the Treatment of Adult Incontinence-associated Dermatitis: a Meta Analysis
作者:
张丽平1, 李维燕1, 董俊刚1, 闫进琳1, 包利红1, 王海婷2, 武雪瑞2
1.甘肃省中医院，甘肃 兰州 730050
2.甘肃中医药大学，甘肃 兰州 730000
Author(s):
ZHANG Liping1, LI Weiyan1, DONG Jungan1, YAN Jinlin1, BAO Lihong1, WANG Haiting2, WU Xuerui2
1.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
2.Gansu University of Chinese Medicine, Lanzhou 730000, China
关键词:
失禁相关性皮炎; 紫草油; 外治; 数据分析
Keywords:
incontinence-associated dermatitis; comfrey oil; external application; data analysis
分类号:
R275.9
DOI:
10.12174/j.issn.2096-9600.2024.12.19
文献标志码:
A
摘要:
目的用Meta分析法评价紫草油治疗失禁相关性皮炎（incontinence-associated dermatitis，IAD）的有效性和安全性。 方法检索中国知网（CNKI）、中国生物医学文献服务系统（SinoMed）、维普期刊网（VIP）、万方数据知识服务平台（Wanfang Data）、PubMed、Medline、The Cochrane Library、Embase数据库，并使用Google、百度等搜索引擎手工检索查漏补缺，收集使用紫草油治疗成人IAD的临床（randomized controlled trial，RCT），运用Cochrane 5.1.0版系统评价手册中随机对照试验质量评价标准对纳入文献进行偏倚风险评估，采用Rev Man 5.3软件进行Meta分析。 结果共纳入8项研究有608例患者，其中治疗组和对照组各304例。Meta分析结果显示：紫草油治疗成人IAD，与其他治疗（常规清洁、造口粉、新曲米松软膏、奈地芬酮康唑乳膏、达克罗宁）相比，在有效率、痊愈率和平均痊愈天数方面均有显著性差异。1）紫草油治疗IAD在总有效率方面具有优势（RR=1.26，95%CI：1.16～1.36，P＜0.000 01）；2）紫草油治疗IAD在痊愈率方面具有优势（RR=1.40，95%CI：1.11～1.77，P=0.005＜0.05）；3）紫草油治疗IAD在平均愈合天数方面具有优势（WMD=-2.65，95%CI：-3.72～-1.58，P＜0.000 01）。 结论紫草油治疗成人IAD能提高有效率、治愈率，缩短治疗时间，有一定的临床疗效优势；但因纳入研究的样本数量较少，文献总体质量偏低，证据质量级别较低，临床使用该证据时仍需谨慎。
Abstract:
ObjectiveTo assess the effectiveness and safety of comfrey oil in the treatment of incontinence-associated dermatitis (IAD) using Meta analysis. MethodsRandomized controlled trial (RCT) on treating adult IAD with comfrey oil were collected by searching CNKI, SinoMed, VIP, Wanfang data, PubMed, Medline, The Cochrane Library, Embase database, and manual retrieval from Google and Baidu so as to fill in the gaps, the risk of bias assessment was carried out on the included literature by using the criteria for quality control of RCTs in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0), Meta analysis was performed using Rev Man 5.3 software. ResultsEight studies with 608 patients were enrolled, among them, there were 304 cases in both the treatment group and the control group respectively. The results of Meta analysis showed that the significant difference could be found in the effective rate, cure rate, the average number of days to recovery when the treat-ment of IAD with comfrey oil was compared with other therapies (regular cleaning, ostomy powder, neotrime-thasone ointment, nedifene ketoconazole cream, dacronine). 1) the treatment of IAD with comfrey oil has the advantage in total effective rate (RR=1.26, 95%CI:1.16～1.36, P<0.000 01); 2)the treatment owns the advantage in the cure rate (RR=1.40, 95%CI:1.11～1.77, P=0.005<0.05); 3) the therapy is good at the average number of days to recovery (WMD=-2.65, 95%CI:-3.72～1.58, P<0.000 01). ConclusionThe treatment of IAD with comfrey oil could raise the effective rate and the cure rate, and reduce the duration of therapy, with certain advantages in clinical effects. However, due to the small sample size of the included studies, the low overall quality of the literature, and the low quality of evidence, clinical use of this evidence still requires caution.

备注/Memo

备注/Memo:
张丽平（1973—），女，主任护师。研究方向：外科护理及护理管理。E-mail：1526920283@qq.com。甘肃省自然科学基金（22JR5RA629）；甘肃中医药大学成果转化培育项目（2023CGZH-15）。
更新日期/Last Update: 2024-12-15